Associations between the presence of specific antibodies to the
West Nile Virus infection and candidate genes in Romanian
horses from the Danube delta

J 2019

Associations between the presence of specific antibodies to the West Nile Virus infection and candidate genes in Romanian horses from the Danube delta

STEJSKALOVA, K., E. JANOVA, C. HORECKY, E. HORECKA, P. VACLAVEK et. al.

Základní údaje

Originální název

Associations between the presence of specific antibodies to the West Nile Virus infection and candidate genes in Romanian horses from the Danube delta

Autoři

STEJSKALOVA, K. (203 Česká republika), E. JANOVA (203 Česká republika), C. HORECKY (203 Česká republika), E. HORECKA (203 Česká republika), P. VACLAVEK (203 Česká republika), Z. HUBALEK (203 Česká republika), K. RELLING (203 Česká republika), Michaela CVANOVÁ (203 Česká republika, domácí), G. D'AMICO (642 Rumunsko), A. D. MIHALCA (642 Rumunsko), D. MODRY (203 Česká republika), A. KNOLL (203 Česká republika) a P. HORIN (203 Česká republika, garant)

Vydání

MOLECULAR BIOLOGY REPORTS, DORDRECHT, Springer, 2019, 0301-4851

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10608 Biochemistry and molecular biology

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 1.402

Kód RIV

RIV/00216224:14110/19:00112955

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1007/s11033-019-04900-w

UT WoS

000478684300078

Klíčová slova anglicky

West Nile virus; Horse; Restriction fragment length polymorphism; Microsatellite; SLC11A1; TLR4; MHC; NKR; Polymorphism

Štítky

14119612, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 17. 2. 2020 09:36, Mgr. Tereza Miškechová

Anotace

V originále

The West Nile virus (WNV) is a mosquito-borne flavivirus causing meningoencephalitis in humans and animals. Due to their particular susceptibility to WNV infection, horses serve as a sentinel species. In a population of Romanian semi-feral horses living in the Danube delta region, we have analyzed the distribution of candidate polymorphic genetic markers between anti WNV-IgG seropositive and seronegative horses. Thirty-six SNPs located in 28 immunity-related genes and 26 microsatellites located in the MHC and LY49 complex genomic regions were genotyped in 57 seropositive and 32 seronegative horses. The most significant association (p(corr)<0.0002) was found for genotypes composed of markers of the SLC11A1 and TLR4 genes. Markers of five other candidate genes (ADAM17, CXCR3, IL12A, MAVS, TNFA), along with 5 MHC class I and LY49-linked microsatellites were also associated with the WNV antibody status in this model horse population. The OAS1 gene, previously associated with WNV-induced clinical disease, was not associated with the presence of anti-WNV antibodies.

Návaznosti

LQ1601, projekt VaV

Název: CEITEC 2020 (Akronym: CEITEC2020)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CEITEC 2020

Citovat

STEJSKALOVA, K., E. JANOVA, C. HORECKY, E. HORECKA, P. VACLAVEK, Z. HUBALEK, K. RELLING, Michaela CVANOVÁ, G. D'AMICO, A. D. MIHALCA, D. MODRY, A. KNOLL a P. HORIN. Associations between the presence of specific antibodies to the West Nile Virus infection and candidate genes in Romanian horses from the Danube delta. MOLECULAR BIOLOGY REPORTS. DORDRECHT: Springer, 2019, roč. 46, č. 4, s. 4453-4461. ISSN 0301-4851. Dostupné z: https://dx.doi.org/10.1007/s11033-019-04900-w.

@article{1622977,
   author = {Stejskalova, K. and Janova, E. and Horecky, C. and Horecka, E. and Vaclavek, P. and Hubalek, Z. and Relling, K. and Cvanová, Michaela and D'Amico, G. and Mihalca, A. D. and Modry, D. and Knoll, A. and Horin, P.},
   article_location = {DORDRECHT},
   article_number = {4},
   doi = {http://dx.doi.org/10.1007/s11033-019-04900-w},
   keywords = {West Nile virus; Horse; Restriction fragment length polymorphism; Microsatellite; SLC11A1; TLR4; MHC; NKR; Polymorphism},
   language = {eng},
   issn = {0301-4851},
   journal = {MOLECULAR BIOLOGY REPORTS},
   title = {Associations between the presence of specific antibodies to the West Nile Virus infection and candidate genes in Romanian horses from the Danube delta},
   url = {http://dx.doi.org/10.1007/s11033-019-04900-w},
   volume = {46},
   year = {2019}
}

TY  - JOUR
ID  - 1622977
AU  - Stejskalova, K. - Janova, E. - Horecky, C. - Horecka, E. - Vaclavek, P. - Hubalek, Z. - Relling, K. - Cvanová, Michaela - D'Amico, G. - Mihalca, A. D. - Modry, D. - Knoll, A. - Horin, P.
PY  - 2019
TI  - Associations between the presence of specific antibodies to the West Nile Virus infection and candidate genes in Romanian horses from the Danube delta
JF  - MOLECULAR BIOLOGY REPORTS
VL  - 46
IS  - 4
SP  - 4453-4461
EP  - 4453-4461
PB  - Springer
SN  - 03014851
KW  - West Nile virus
KW  - Horse
KW  - Restriction fragment length polymorphism
KW  - Microsatellite
KW  - SLC11A1
KW  - TLR4
KW  - MHC
KW  - NKR
KW  - Polymorphism
UR  - http://dx.doi.org/10.1007/s11033-019-04900-w
L2  - http://dx.doi.org/10.1007/s11033-019-04900-w
N2  - The West Nile virus (WNV) is a mosquito-borne flavivirus causing meningoencephalitis in humans and animals. Due to their particular susceptibility to WNV infection, horses serve as a sentinel species. In a population of Romanian semi-feral horses living in the Danube delta region, we have analyzed the distribution of candidate polymorphic genetic markers between anti WNV-IgG seropositive and seronegative horses. Thirty-six SNPs located in 28 immunity-related genes and 26 microsatellites located in the MHC and LY49 complex genomic regions were genotyped in 57 seropositive and 32 seronegative horses. The most significant association (p(corr)<0.0002) was found for genotypes composed of markers of the SLC11A1 and TLR4 genes. Markers of five other candidate genes (ADAM17, CXCR3, IL12A, MAVS, TNFA), along with 5 MHC class I and LY49-linked microsatellites were also associated with the WNV antibody status in this model horse population. The OAS1 gene, previously associated with WNV-induced clinical disease, was not associated with the presence of anti-WNV antibodies.
ER  -

STEJSKALOVA, K., E. JANOVA, C. HORECKY, E. HORECKA, P. VACLAVEK, Z. HUBALEK, K. RELLING, Michaela CVANOVÁ, G. D'AMICO, A. D. MIHALCA, D. MODRY, A. KNOLL a P. HORIN. Associations between the presence of specific antibodies to the West Nile Virus infection and candidate genes in Romanian horses from the Danube delta. \textit{MOLECULAR BIOLOGY REPORTS}. DORDRECHT: Springer, 2019, roč.~46, č.~4, s.~4453-4461. ISSN~0301-4851. Dostupné z: https://dx.doi.org/10.1007/s11033-019-04900-w.

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