Ovarian Cancer: Differentially Expressed microRNAs in Tumor
Tissue and Cell-Free Ascitic Fluid as Potential Novel
Biomarkers

J 2019

Ovarian Cancer: Differentially Expressed microRNAs in Tumor Tissue and Cell-Free Ascitic Fluid as Potential Novel Biomarkers

ZAVESKY, Ludek, Eva JANDÁKOVÁ, Vít WEINBERGER, Luboš MINÁŘ, Veronika HANZIKOVA et. al.

Základní údaje

Originální název

Ovarian Cancer: Differentially Expressed microRNAs in Tumor Tissue and Cell-Free Ascitic Fluid as Potential Novel Biomarkers

Autoři

ZAVESKY, Ludek (203 Česká republika, garant), Eva JANDÁKOVÁ (203 Česká republika, domácí), Vít WEINBERGER (203 Česká republika, domácí), Luboš MINÁŘ (203 Česká republika, domácí), Veronika HANZIKOVA (203 Česká republika), Daniela DUSKOVA (203 Česká republika), Lenka ZAVESKA DRABKOVA (203 Česká republika) a Ales HORINEK (203 Česká republika)

Vydání

Cancer Investigation, PHILADELPHIA, TAYLOR & FRANCIS, 2019, 0735-7907

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30204 Oncology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.398

Kód RIV

RIV/00216224:14110/19:00112959

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1080/07357907.2019.1663208

UT WoS

000486781600001

Klíčová slova anglicky

Ovarian cancer; ascites; effusion; microRNA; tumor

Štítky

14110230, 14110411, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 17. 2. 2020 11:01, Mgr. Tereza Miškechová

Anotace

V originále

Ovarian cancer is the deadliest gynecologic cancer. The large-scale microRNA (miRNA) expression profiling and individual miRNA validation was performed to find potential novel biomarkers for ovarian cancer. The most consistent overexpression of miRs-200b-3p, 135 b-5p and 182-5p was found in both ascitic fluid and tumors and suggests their potential as oncogenes. miR-451a was consistently underexpressed so may be a tumor suppressor. Results were inconsistent for miR-204-5p, which was overexpressed in ascitic fluid but underexpressed in tumor tissue. miR-203a-3p was generally overexpressed but this failed to be proved in independent sample set in tissue validation.

Citovat

ZAVESKY, Ludek, Eva JANDÁKOVÁ, Vít WEINBERGER, Luboš MINÁŘ, Veronika HANZIKOVA, Daniela DUSKOVA, Lenka ZAVESKA DRABKOVA a Ales HORINEK. Ovarian Cancer: Differentially Expressed microRNAs in Tumor Tissue and Cell-Free Ascitic Fluid as Potential Novel Biomarkers. Cancer Investigation. PHILADELPHIA: TAYLOR & FRANCIS, 2019, roč. 37, č. 9, s. 440-452. ISSN 0735-7907. Dostupné z: https://dx.doi.org/10.1080/07357907.2019.1663208.

@article{1623056,
   author = {Zavesky, Ludek and Jandáková, Eva and Weinberger, Vít and Minář, Luboš and Hanzikova, Veronika and Duskova, Daniela and Zaveska Drabkova, Lenka and Horinek, Ales},
   article_location = {PHILADELPHIA},
   article_number = {9},
   doi = {http://dx.doi.org/10.1080/07357907.2019.1663208},
   keywords = {Ovarian cancer; ascites; effusion; microRNA; tumor},
   language = {eng},
   issn = {0735-7907},
   journal = {Cancer Investigation},
   title = {Ovarian Cancer: Differentially Expressed microRNAs in Tumor Tissue and Cell-Free Ascitic Fluid as Potential Novel Biomarkers},
   url = {http://dx.doi.org/10.1080/07357907.2019.1663208},
   volume = {37},
   year = {2019}
}

TY  - JOUR
ID  - 1623056
AU  - Zavesky, Ludek - Jandáková, Eva - Weinberger, Vít - Minář, Luboš - Hanzikova, Veronika - Duskova, Daniela - Zaveska Drabkova, Lenka - Horinek, Ales
PY  - 2019
TI  - Ovarian Cancer: Differentially Expressed microRNAs in Tumor Tissue and Cell-Free Ascitic Fluid as Potential Novel Biomarkers
JF  - Cancer Investigation
VL  - 37
IS  - 9
SP  - 440-452
EP  - 440-452
PB  - TAYLOR & FRANCIS
SN  - 07357907
KW  - Ovarian cancer
KW  - ascites
KW  - effusion
KW  - microRNA
KW  - tumor
UR  - http://dx.doi.org/10.1080/07357907.2019.1663208
L2  - http://dx.doi.org/10.1080/07357907.2019.1663208
N2  - Ovarian cancer is the deadliest gynecologic cancer. The large-scale microRNA (miRNA) expression profiling and individual miRNA validation was performed to find potential novel biomarkers for ovarian cancer. The most consistent overexpression of miRs-200b-3p, 135 b-5p and 182-5p was found in both ascitic fluid and tumors and suggests their potential as oncogenes. miR-451a was consistently underexpressed so may be a tumor suppressor. Results were inconsistent for miR-204-5p, which was overexpressed in ascitic fluid but underexpressed in tumor tissue. miR-203a-3p was generally overexpressed but this failed to be proved in independent sample set in tissue validation.
ER  -

ZAVESKY, Ludek, Eva JANDÁKOVÁ, Vít WEINBERGER, Luboš MINÁŘ, Veronika HANZIKOVA, Daniela DUSKOVA, Lenka ZAVESKA DRABKOVA a Ales HORINEK. Ovarian Cancer: Differentially Expressed microRNAs in Tumor Tissue and Cell-Free Ascitic Fluid as Potential Novel Biomarkers. \textit{Cancer Investigation}. PHILADELPHIA: TAYLOR \&{} FRANCIS, 2019, roč.~37, č.~9, s.~440-452. ISSN~0735-7907. Dostupné z: https://dx.doi.org/10.1080/07357907.2019.1663208.

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