Prognostic Value of MiR-21: An Updated Meta-Analysis in Head
and Neck Squamous Cell Carcinoma (HNSCC)

J 2019

Prognostic Value of MiR-21: An Updated Meta-Analysis in Head and Neck Squamous Cell Carcinoma (HNSCC)

IRIMIE-AGHIORGHIESEI, Alexandra Iulia; Cecilia POP-BICA; Sebastian PINTEA; Cornelia BRAICU; Roxana COJOCNEANU et. al.

Základní údaje

Originální název

Prognostic Value of MiR-21: An Updated Meta-Analysis in Head and Neck Squamous Cell Carcinoma (HNSCC)

Autoři

IRIMIE-AGHIORGHIESEI, Alexandra Iulia (642 Rumunsko); Cecilia POP-BICA (642 Rumunsko); Sebastian PINTEA (642 Rumunsko); Cornelia BRAICU (642 Rumunsko); Roxana COJOCNEANU (642 Rumunsko); Alina-Andreea ZIMTA (642 Rumunsko); Diana GULEI (642 Rumunsko); Ondřej SLABÝ (203 Česká republika, garant, domácí) a Ioana BERINDAN-NEAGOE (642 Rumunsko)

Vydání

Journal of Clinical Medicine, BASEL, MDPI, 2019, 2077-0383

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30204 Oncology

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.303

Kód RIV

RIV/00216224:14740/19:00112963

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.3390/jcm8122041

UT WoS

000506640400016

EID Scopus

2-s2.0-85086154272

Klíčová slova anglicky

miR-21; head and neck cancer; survival; prognostic; bioinformatics analysis

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 17. 2. 2020 15:39, Mgr. Pavla Foltynová, Ph.D.

Anotace

V originále

Head and neck squamous cell carcinoma (HNSCC) is a group of malignancies with serious impact on patient quality of life due to a reduced rate of response to chemotherapy or radiation therapy. MiR-21 has been identified as one of the most common proto-oncogenes. It is hypothesized that upregulated miR-21 could serve as a potential biomarker for human cancer diagnosis. Considering the target genes identified for miR-21 in HNSCC, this transcript is an important player in several cellular processes that control carcinogenesis. The abnormal expression of miR-21 in this group of pathologies has been assessed in several publications, but given the heterogeneity of the published results, a meta-analysis and proper bioinformatics analysis of expression databases are needed to correctly establish the prognostic potential of this molecule. The present meta-analysis comprises the published survival data on HNSCC patients, reported as HR and 95% CI, in association with the expression levels of miR-21. Our investigation revealed that miR-21 could be used successfully as a prognostic biomarker in HNSCC patients, confirming its oncogenic potential. Specifically, the upregulation of miR-21 in these patients predicts a worse outcome in terms of survival rate.

Návaznosti

824036, interní kód MU

Název: Excellence in research and development of non-coding RNA DIAGnostics in ONcology (Akronym: RNADIAGON)

Investor: Evropská unie, Excellence in research and development of non-coding RNA DIAGnostics in ONcology, MSCA Marie Skłodowska-Curie Actions (Excellent Science)

Přiložené soubory

jcm-08-02041-v2.pdf

Citovat

IRIMIE-AGHIORGHIESEI, Alexandra Iulia; Cecilia POP-BICA; Sebastian PINTEA; Cornelia BRAICU; Roxana COJOCNEANU; Alina-Andreea ZIMTA; Diana GULEI; Ondřej SLABÝ a Ioana BERINDAN-NEAGOE. Prognostic Value of MiR-21: An Updated Meta-Analysis in Head and Neck Squamous Cell Carcinoma (HNSCC). Journal of Clinical Medicine. BASEL: MDPI, 2019, roč. 8, č. 12, s. 1-17. ISSN 2077-0383. Dostupné z: https://dx.doi.org/10.3390/jcm8122041.

@article{1623216,
   author = {IrimieandAghiorghiesei, Alexandra Iulia and PopandBica, Cecilia and Pintea, Sebastian and Braicu, Cornelia and Cojocneanu, Roxana and Zimta, AlinaandAndreea and Gulei, Diana and Slabý, Ondřej and BerindanandNeagoe, Ioana},
   article_location = {BASEL},
   article_number = {12},
   doi = {http://dx.doi.org/10.3390/jcm8122041},
   keywords = {miR-21; head and neck cancer; survival; prognostic; bioinformatics analysis},
   language = {eng},
   issn = {2077-0383},
   journal = {Journal of Clinical Medicine},
   title = {Prognostic Value of MiR-21: An Updated Meta-Analysis in Head and Neck Squamous Cell Carcinoma (HNSCC)},
   url = {https://www.mdpi.com/2077-0383/8/12/2041/htm},
   volume = {8},
   year = {2019}
}

TY  - JOUR
ID  - 1623216
AU  - Irimie-Aghiorghiesei, Alexandra Iulia - Pop-Bica, Cecilia - Pintea, Sebastian - Braicu, Cornelia - Cojocneanu, Roxana - Zimta, Alina-Andreea - Gulei, Diana - Slabý, Ondřej - Berindan-Neagoe, Ioana
PY  - 2019
TI  - Prognostic Value of MiR-21: An Updated Meta-Analysis in Head and Neck Squamous Cell Carcinoma (HNSCC)
JF  - Journal of Clinical Medicine
VL  - 8
IS  - 12
SP  - 1-17
EP  - 1-17
PB  - MDPI
SN  - 20770383
KW  - miR-21
KW  - head and neck cancer
KW  - survival
KW  - prognostic
KW  - bioinformatics analysis
UR  - https://www.mdpi.com/2077-0383/8/12/2041/htm
L2  - https://www.mdpi.com/2077-0383/8/12/2041/htm
N2  - Head and neck squamous cell carcinoma (HNSCC) is a group of malignancies with serious impact on patient quality of life due to a reduced rate of response to chemotherapy or radiation therapy. MiR-21 has been identified as one of the most common proto-oncogenes. It is hypothesized that upregulated miR-21 could serve as a potential biomarker for human cancer diagnosis. Considering the target genes identified for miR-21 in HNSCC, this transcript is an important player in several cellular processes that control carcinogenesis. The abnormal expression of miR-21 in this group of pathologies has been assessed in several publications, but given the heterogeneity of the published results, a meta-analysis and proper bioinformatics analysis of expression databases are needed to correctly establish the prognostic potential of this molecule. The present meta-analysis comprises the published survival data on HNSCC patients, reported as HR and 95% CI, in association with the expression levels of miR-21. Our investigation revealed that miR-21 could be used successfully as a prognostic biomarker in HNSCC patients, confirming its oncogenic potential. Specifically, the upregulation of miR-21 in these patients predicts a worse outcome in terms of survival rate.
ER  -

IRIMIE-AGHIORGHIESEI, Alexandra Iulia; Cecilia POP-BICA; Sebastian PINTEA; Cornelia BRAICU; Roxana COJOCNEANU; Alina-Andreea ZIMTA; Diana GULEI; Ondřej SLABÝ a Ioana BERINDAN-NEAGOE. Prognostic Value of MiR-21: An Updated Meta-Analysis in Head and Neck Squamous Cell Carcinoma (HNSCC). \textit{Journal of Clinical Medicine}. BASEL: MDPI, 2019, roč.~8, č.~12, s.~1-17. ISSN~2077-0383. Dostupné z: https://dx.doi.org/10.3390/jcm8122041.

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