2019
Pentraxin 3 in Noninvasively Obtained Cervical Fluid Samples from Pregnancies Complicated by Preterm Prelabor Rupture of Membranes
JANKŮ, Petr, Marian KACEROVSKY, Barbora ZEDNIKOVA, Ctirad ANDRYS, Martina KOLACKOVA et. al.Základní údaje
Originální název
Pentraxin 3 in Noninvasively Obtained Cervical Fluid Samples from Pregnancies Complicated by Preterm Prelabor Rupture of Membranes
Autoři
JANKŮ, Petr (203 Česká republika, domácí), Marian KACEROVSKY (203 Česká republika, garant), Barbora ZEDNIKOVA (203 Česká republika), Ctirad ANDRYS (203 Česká republika), Martina KOLACKOVA (203 Česká republika), Marcela DRAHOSOVA (203 Česká republika), Lenka PLISKOVA (203 Česká republika), Helena ZEMLICKOVA (203 Česká republika), Romana GERYCHOVÁ (203 Česká republika, domácí), Ondrej SIMETKA (203 Česká republika), Petr MATLAK (203 Česká republika), Bo JACOBSSON (752 Švédsko) a Ivana MUSILOVA (203 Česká republika)
Vydání
Fetal Diagnosis and Therapy, Basel, Karger, 2019, 1015-3837
Další údaje
Jazyk
angličtina
Typ výsledku
Článek v odborném periodiku
Obor
30214 Obstetrics and gynaecology
Stát vydavatele
Švýcarsko
Utajení
není předmětem státního či obchodního tajemství
Odkazy
Impakt faktor
Impact factor: 2.095
Kód RIV
RIV/00216224:14110/19:00112965
Organizační jednotka
Lékařská fakulta
UT WoS
000507387300007
Klíčová slova anglicky
Inflammation; Microorganism; Pattern recognition receptor; Preterm birth
Příznaky
Mezinárodní význam, Recenzováno
Změněno: 11. 5. 2020 13:30, Mgr. Tereza Miškechová
Anotace
V originále
Problem: To determine the changes of pentraxin 3 (PTX3) level in noninvasively obtained cervical fluid samples from women with preterm prelabor rupture of membranes (PPROM) based on the presence of microbial invasion of the amniotic cavity (MIAC) and/or intra-amniotic inflammation (IAI), and intra-amniotic infection (the presence of both MIAC and IAI). Methods of Study: A total of 160 women with PPROM were included. Cervical fluid samples were obtained using a Dacron polyester swab and amniotic fluid samples were obtained by transabdominal amniocentesis. Cervical fluid PTX3 levels were assessed using enzyme-linked immunosorbent assay. Results: PTX3 was found in all the cervical fluid samples and its levels were higher in women with MIAC, IAI, and intra-amniotic infection than in women without these conditions. When the women were categorized into four subgroups based on the presence of MIAC and/or IAI, women with intra-amniotic infection had higher cervical fluid PTX3 levels than those with sterile IAI (IAI alone), colonization (MIAC alone), or no MIAC or IAI. A cervical fluid PTX3 level of 11 ng/mL was the best value for identifying the presence of intra-amniotic infection in women with PPROM. Conclusions: PTX3 is a constituent of cervical fluid of women with PPROM. Cervical fluid PTX3 level reflects the situation in the intra-amniotic compartments of women with PPROM. Cervical fluid PTX3 is a potential marker for the noninvasive identification of intra-amniotic infection in PPROM.