Sex and race differences in J-Tend, J-Tpeak, and Tpeak-Tend
intervals

J 2019

Sex and race differences in J-Tend, J-Tpeak, and Tpeak-Tend intervals

HNATKOVA, Katerina, Ondřej TOMAN, Martina ŠIŠÁKOVÁ, Peter SMETANA, Katharina M. HUSTER et. al.

Základní údaje

Originální název

Sex and race differences in J-Tend, J-Tpeak, and Tpeak-Tend intervals

Autoři

HNATKOVA, Katerina (826 Velká Británie a Severní Irsko), Ondřej TOMAN (203 Česká republika, domácí), Martina ŠIŠÁKOVÁ (203 Česká republika, domácí), Peter SMETANA (40 Rakousko), Katharina M. HUSTER (276 Německo), Petra BARTHEL (276 Německo), Tomáš NOVOTNÝ (203 Česká republika, domácí), Georg SCHMIDT (276 Německo) a Marek MALIK (826 Velká Británie a Severní Irsko, garant)

Vydání

Scientific reports, LONDON, NATURE PUBLISHING GROUP, 2019, 2045-2322

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.998

Kód RIV

RIV/00216224:14110/19:00112966

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1038/s41598-019-56328-8

UT WoS

000508960600003

Klíčová slova anglicky

QT INTERVAL; HEART-RATE; HEALTHY-SUBJECTS; SAMPLE-SIZE; THOROUGH; MORTALITY; BLOCK

Štítky

14110211, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 17. 2. 2020 15:21, Mgr. Tereza Miškechová

Anotace

V originále

To facilitate the precision of clinical electrocardiographic studies of J-to-Tpeak (JTp) and Tpeak-to-Tend (Tpe) intervals, the study investigated their differences between healthy females and males, and between subjects of African and Caucasian origin. In 523 healthy subjects (254 females; 236 subjects of African origin), repeated Holter recordings were used to measure QT, JT, JTp, and Tpe intervals preceded by both stable and variable heart rates. Subject-specific curvilinear regression models were used to obtain individual QTc, JTc, JTpc and Tpec intervals. Rate hysteresis, i.e., the speed with which the intervals adapted after heart rate changes, was also investigated. In all sex-race groups, Tpe intervals were not systematically heart rate dependent. Similar to QTc intervals, women had JTc, and JTpc intervals longer than males (difference 20-30 ms, p < 0.001). However, women had Tpec intervals (and rate uncorrected Tpe intervals) shorter by approximately 10 ms compared to males (p < 0.001). Subjects of African origin had significantly shorter QTc intervals than Caucasians (p < 0.001). Gradually diminishing race-difference was found for JTc, JTpc and Tpec intervals. JTc and JTpc were moderately increasing with age but Tpe/Tpec were not. Rate hysteresis of JTp was approximately 10% longer compared to that of JT (p < 0.001). In future clinical studies, Tpe interval should not be systematically corrected for heart rate and similar to the QT interval, the differences in JT, JTp and Tpe intervals should be corrected for sex. The differences in QT and JT, and JTp intervals should also be corrected for race.

Citovat

HNATKOVA, Katerina, Ondřej TOMAN, Martina ŠIŠÁKOVÁ, Peter SMETANA, Katharina M. HUSTER, Petra BARTHEL, Tomáš NOVOTNÝ, Georg SCHMIDT a Marek MALIK. Sex and race differences in J-Tend, J-Tpeak, and Tpeak-Tend intervals. Scientific reports. LONDON: NATURE PUBLISHING GROUP, 2019, roč. 9, DEC 27 2019, s. 1-16. ISSN 2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-019-56328-8.

@article{1623336,
   author = {Hnatkova, Katerina and Toman, Ondřej and Šišáková, Martina and Smetana, Peter and Huster, Katharina M. and Barthel, Petra and Novotný, Tomáš and Schmidt, Georg and Malik, Marek},
   article_location = {LONDON},
   article_number = {DEC 27 2019},
   doi = {http://dx.doi.org/10.1038/s41598-019-56328-8},
   keywords = {QT INTERVAL; HEART-RATE; HEALTHY-SUBJECTS; SAMPLE-SIZE; THOROUGH; MORTALITY; BLOCK},
   language = {eng},
   issn = {2045-2322},
   journal = {Scientific reports},
   title = {Sex and race differences in J-Tend, J-Tpeak, and Tpeak-Tend intervals},
   url = {http://dx.doi.org/10.1038/s41598-019-56328-8},
   volume = {9},
   year = {2019}
}

TY  - JOUR
ID  - 1623336
AU  - Hnatkova, Katerina - Toman, Ondřej - Šišáková, Martina - Smetana, Peter - Huster, Katharina M. - Barthel, Petra - Novotný, Tomáš - Schmidt, Georg - Malik, Marek
PY  - 2019
TI  - Sex and race differences in J-Tend, J-Tpeak, and Tpeak-Tend intervals
JF  - Scientific reports
VL  - 9
IS  - DEC 27 2019
SP  - 1-16
EP  - 1-16
PB  - NATURE PUBLISHING GROUP
SN  - 20452322
KW  - QT INTERVAL
KW  - HEART-RATE
KW  - HEALTHY-SUBJECTS
KW  - SAMPLE-SIZE
KW  - THOROUGH
KW  - MORTALITY
KW  - BLOCK
UR  - http://dx.doi.org/10.1038/s41598-019-56328-8
L2  - http://dx.doi.org/10.1038/s41598-019-56328-8
N2  - To facilitate the precision of clinical electrocardiographic studies of J-to-Tpeak (JTp) and Tpeak-to-Tend (Tpe) intervals, the study investigated their differences between healthy females and males, and between subjects of African and Caucasian origin. In 523 healthy subjects (254 females; 236 subjects of African origin), repeated Holter recordings were used to measure QT, JT, JTp, and Tpe intervals preceded by both stable and variable heart rates. Subject-specific curvilinear regression models were used to obtain individual QTc, JTc, JTpc and Tpec intervals. Rate hysteresis, i.e., the speed with which the intervals adapted after heart rate changes, was also investigated. In all sex-race groups, Tpe intervals were not systematically heart rate dependent. Similar to QTc intervals, women had JTc, and JTpc intervals longer than males (difference 20-30 ms, p < 0.001). However, women had Tpec intervals (and rate uncorrected Tpe intervals) shorter by approximately 10 ms compared to males (p < 0.001). Subjects of African origin had significantly shorter QTc intervals than Caucasians (p < 0.001). Gradually diminishing race-difference was found for JTc, JTpc and Tpec intervals. JTc and JTpc were moderately increasing with age but Tpe/Tpec were not. Rate hysteresis of JTp was approximately 10% longer compared to that of JT (p < 0.001). In future clinical studies, Tpe interval should not be systematically corrected for heart rate and similar to the QT interval, the differences in JT, JTp and Tpe intervals should be corrected for sex. The differences in QT and JT, and JTp intervals should also be corrected for race.
ER  -

HNATKOVA, Katerina, Ondřej TOMAN, Martina ŠIŠÁKOVÁ, Peter SMETANA, Katharina M. HUSTER, Petra BARTHEL, Tomáš NOVOTNÝ, Georg SCHMIDT a Marek MALIK. Sex and race differences in J-Tend, J-Tpeak, and Tpeak-Tend intervals. \textit{Scientific reports}. LONDON: NATURE PUBLISHING GROUP, 2019, roč.~9, DEC 27 2019, s.~1-16. ISSN~2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-019-56328-8.

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