2019
MicroRNA-215: From biology to theranostic applications
VYCHYTILOVÁ, Petra a Ondřej SLABÝZákladní údaje
Originální název
MicroRNA-215: From biology to theranostic applications
Autoři
VYCHYTILOVÁ, Petra (203 Česká republika, domácí) a Ondřej SLABÝ (203 Česká republika, garant, domácí)
Vydání
Molecular aspects of medicine, Amsterdam, Elsevier, 2019, 0098-2997
Další údaje
Jazyk
angličtina
Typ výsledku
Článek v odborném periodiku
Obor
10608 Biochemistry and molecular biology
Stát vydavatele
Nizozemské království
Utajení
není předmětem státního či obchodního tajemství
Odkazy
Impakt faktor
Impact factor: 9.577
Kód RIV
RIV/00216224:14740/19:00108155
Organizační jednotka
Středoevropský technologický institut
UT WoS
000498912100006
Klíčová slova anglicky
miR-215; Proliferation; Cell cycle; Apoptosis; Biomarker; Therapeutic target
Štítky
Příznaky
Mezinárodní význam, Recenzováno
Změněno: 31. 3. 2020 21:44, Mgr. Pavla Foltynová, Ph.D.
Anotace
V originále
MicroRNA-215 (miR-215) is one of the extensively studied microRNAs (miRNAs) in human diseases, especially in different types of cancer, where it plays various roles in the initiation and progression of tumors. There is also a high conservation of miR-215 among wide range of different species indicating that this miRNA may have vital functions that are maintained during evolution. During the last ten years, significant efforts were dedicated to uncover molecular mechanisms of miR-215 regulation and cellular functioning. In addition, miR-215 was repeatedly identified to have the causal roles in pathology of various diseases, where it may serve as a promising diagnostic, prognostic or predictive biomarker and as a therapeutic target. Here, we overview more than 150 reports focused on miR-215 to allow the synthesis of knowledge on its transcriptional and post-transcriptional regulation, and functioning in essential biological processes like cell and tissue development, cell survival, cell cycle and proliferation, cell migration and invasion, cellular microenvironment communication, and metabolism. Further, we summarized the findings on miR-215 roles in pathology of nonmalignant diseases and various types of cancer with special focus on miR-215 as a promising molecule for future development of theranostic miRNA-based approaches. Although it is difficult to evaluate the full theranostic potential of miR-215, it is probable that during the following years, an increasing number of theranostic miRNA modalities that overcome the current technological obstacles will appear, and enable the translation of miR-215 knowledge into the clinic.
Návaznosti
GA16-18257S, projekt VaV |
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NV16-31765A, projekt VaV |
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