Behavioral and Neuroanatomical Account of Impulsivity in
Parkinson's Disease

J 2020

Behavioral and Neuroanatomical Account of Impulsivity in Parkinson's Disease

HLAVATÁ, Pavlína, Pavla LINHARTOVÁ, Rastislav ŠUMEC, Pavel FILIP, Miroslav SVĚTLÁK et. al.

Základní údaje

Originální název

Behavioral and Neuroanatomical Account of Impulsivity in Parkinson's Disease

Autoři

HLAVATÁ, Pavlína (203 Česká republika, domácí), Pavla LINHARTOVÁ (203 Česká republika, domácí), Rastislav ŠUMEC (703 Slovensko, domácí), Pavel FILIP (703 Slovensko, garant, domácí), Miroslav SVĚTLÁK (203 Česká republika, domácí), Marek BALÁŽ (703 Slovensko, domácí), Tomáš KAŠPÁREK (203 Česká republika, domácí) a Martin BAREŠ (203 Česká republika, domácí)

Vydání

FRONTIERS IN NEUROLOGY, LAUSANNE, FRONTIERS MEDIA SA, 2020, 1664-2295

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30210 Clinical neurology

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.003

Kód RIV

RIV/00216224:14110/20:00115338

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.3389/fneur.2019.01338

UT WoS

000509278800001

Klíčová slova anglicky

impulse control disorder; Parkinson's disease; impulsive action; impulsive choice; structural MRI; Iowa gambling task; delay discounting task; stop signal task

Štítky

14110127, 14110222, 14110523, CF MAFIL, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 9. 10. 2024 12:54, Ing. Jana Kuchtová

Anotace

V originále

Impulse control disorder (ICD) is a major non-motor complication of Parkinson's disease (PD) with often devastating consequences for patients' quality of life. In this study, we aimed to characterize the phenotype of impulsivity in PD and its neuroanatomical correlates. Methods: Thirty-seven PD patients (15 patients with ICD, 22 patients without ICD) and 36 healthy controls underwent a neuropsychological battery. The test battery consisted of anxiety and depression scales, self-report measures of impulsivity (Barratt scale and UPPS-P), behavioral measures of impulsive action (Go/No-Go task, Stop signal task) and impulsive choice (Delay discounting, Iowa gambling task), and measures of cognitive abilities (working memory, attention, executive function). Patients and controls underwent structural MRI scanning. Results: Patients with ICD had significantly higher levels of self-reported impulsivity (Barratt scale and Lack of perseverance from UPPS-P) in comparison with healthy controls and non-impulsive PD patients, but they performed similarly in behavioral tasks, except for the Iowa gambling task. In this task, patients with ICD made significantly less risky decisions than patients without ICD and healthy controls. Patients without ICD did not differ from healthy controls in self-reported impulsivity or behavioral measurements. Both patient groups were more anxious and depressive than healthy controls. MRI scanning revealed structural differences in cortical areas related to impulse control in both patient groups. Patients without ICD had lower volumes and cortical thickness of bilateral inferior frontal gyrus. Patients with ICD had higher volumes of right caudal anterior cingulate and rostral middle frontal cortex. Conclusions: Despite the presence of ICD as confirmed by both clinical follow-up and self-reported impulsivity scales and supported by structural differences in various neural nodes related to inhibitory control and reward processing, patients with ICD performed no worse than healthy controls in various behavioral tasks previously hypothesized as robust impulsivity measures. These results call for caution against impetuous interpretation of behavioral tests, since various factors may and will influence the ultimate outcomes, be it the lack of sensitivity in specific, limited ICD subtypes, excessive caution of ICD patients during testing due to previous negative experience rendering simplistic tasks insufficient, or other, as of now unknown aspects, calling for further research.

Návaznosti

NV15-30062A, projekt VaV

Název: Fenotypy impulzivity u neuropsychiatrických poruch a jejich klinický význam

691110, interní kód MU

Název: Advanced MR methods for characterization of microstructural brain damage (MICROBRADAM) (Akronym: MICROBRADAM)

Investor: Evropská unie, Advanced MR methods for characterization of microstructural brain damage (MICROBRADAM), MSCA Marie Skłodowska-Curie Actions (Excellent Science)

90062, velká výzkumná infrastruktura

Název: Czech-BioImaging

Citovat

HLAVATÁ, Pavlína, Pavla LINHARTOVÁ, Rastislav ŠUMEC, Pavel FILIP, Miroslav SVĚTLÁK, Marek BALÁŽ, Tomáš KAŠPÁREK a Martin BAREŠ. Behavioral and Neuroanatomical Account of Impulsivity in Parkinson's Disease. FRONTIERS IN NEUROLOGY. LAUSANNE: FRONTIERS MEDIA SA, 2020, roč. 10, JAN 10 2020, s. 1-12. ISSN 1664-2295. Dostupné z: https://dx.doi.org/10.3389/fneur.2019.01338.

@article{1623836,
   author = {Hlavatá, Pavlína and Linhartová, Pavla and Šumec, Rastislav and Filip, Pavel and Světlák, Miroslav and Baláž, Marek and Kašpárek, Tomáš and Bareš, Martin},
   article_location = {LAUSANNE},
   article_number = {JAN 10 2020},
   doi = {http://dx.doi.org/10.3389/fneur.2019.01338},
   keywords = {impulse control disorder; Parkinson's disease; impulsive action; impulsive choice; structural MRI; Iowa gambling task; delay discounting task; stop signal task},
   language = {eng},
   issn = {1664-2295},
   journal = {FRONTIERS IN NEUROLOGY},
   title = {Behavioral and Neuroanatomical Account of Impulsivity in Parkinson's Disease},
   url = {http://dx.doi.org/10.3389/fneur.2019.01338},
   volume = {10},
   year = {2020}
}

TY  - JOUR
ID  - 1623836
AU  - Hlavatá, Pavlína - Linhartová, Pavla - Šumec, Rastislav - Filip, Pavel - Světlák, Miroslav - Baláž, Marek - Kašpárek, Tomáš - Bareš, Martin
PY  - 2020
TI  - Behavioral and Neuroanatomical Account of Impulsivity in Parkinson's Disease
JF  - FRONTIERS IN NEUROLOGY
VL  - 10
IS  - JAN 10 2020
SP  - 1-12
EP  - 1-12
PB  - FRONTIERS MEDIA SA
SN  - 16642295
KW  - impulse control disorder
KW  - Parkinson's disease
KW  - impulsive action
KW  - impulsive choice
KW  - structural MRI
KW  - Iowa gambling task
KW  - delay discounting task
KW  - stop signal task
UR  - http://dx.doi.org/10.3389/fneur.2019.01338
L2  - http://dx.doi.org/10.3389/fneur.2019.01338
N2  - Impulse control disorder (ICD) is a major non-motor complication of Parkinson's disease (PD) with often devastating consequences for patients' quality of life. In this study, we aimed to characterize the phenotype of impulsivity in PD and its neuroanatomical correlates. Methods: Thirty-seven PD patients (15 patients with ICD, 22 patients without ICD) and 36 healthy controls underwent a neuropsychological battery. The test battery consisted of anxiety and depression scales, self-report measures of impulsivity (Barratt scale and UPPS-P), behavioral measures of impulsive action (Go/No-Go task, Stop signal task) and impulsive choice (Delay discounting, Iowa gambling task), and measures of cognitive abilities (working memory, attention, executive function). Patients and controls underwent structural MRI scanning. Results: Patients with ICD had significantly higher levels of self-reported impulsivity (Barratt scale and Lack of perseverance from UPPS-P) in comparison with healthy controls and non-impulsive PD patients, but they performed similarly in behavioral tasks, except for the Iowa gambling task. In this task, patients with ICD made significantly less risky decisions than patients without ICD and healthy controls. Patients without ICD did not differ from healthy controls in self-reported impulsivity or behavioral measurements. Both patient groups were more anxious and depressive than healthy controls. MRI scanning revealed structural differences in cortical areas related to impulse control in both patient groups. Patients without ICD had lower volumes and cortical thickness of bilateral inferior frontal gyrus. Patients with ICD had higher volumes of right caudal anterior cingulate and rostral middle frontal cortex. Conclusions: Despite the presence of ICD as confirmed by both clinical follow-up and self-reported impulsivity scales and supported by structural differences in various neural nodes related to inhibitory control and reward processing, patients with ICD performed no worse than healthy controls in various behavioral tasks previously hypothesized as robust impulsivity measures. These results call for caution against impetuous interpretation of behavioral tests, since various factors may and will influence the ultimate outcomes, be it the lack of sensitivity in specific, limited ICD subtypes, excessive caution of ICD patients during testing due to previous negative experience rendering simplistic tasks insufficient, or other, as of now unknown aspects, calling for further research.
ER  -

HLAVATÁ, Pavlína, Pavla LINHARTOVÁ, Rastislav ŠUMEC, Pavel FILIP, Miroslav SVĚTLÁK, Marek BALÁŽ, Tomáš KAŠPÁREK a Martin BAREŠ. Behavioral and Neuroanatomical Account of Impulsivity in Parkinson's Disease. \textit{FRONTIERS IN NEUROLOGY}. LAUSANNE: FRONTIERS MEDIA SA, 2020, roč.~10, JAN 10 2020, s.~1-12. ISSN~1664-2295. Dostupné z: https://dx.doi.org/10.3389/fneur.2019.01338.

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