Different chromosome damage in lymphocytes of newly diagnosed
gastrointestinal and breast cancer patients

J 2020

Different chromosome damage in lymphocytes of newly diagnosed gastrointestinal and breast cancer patients

KADLČÍKOVÁ, Dita, Petra MUSILOVÁ, Hana HRADSKÁ, Markéta PETROVOVÁ, Iveta SELINGEROVÁ et. al.

Základní údaje

Originální název

Different chromosome damage in lymphocytes of newly diagnosed gastrointestinal and breast cancer patients

Autoři

KADLČÍKOVÁ, Dita, Petra MUSILOVÁ, Hana HRADSKÁ, Markéta PETROVOVÁ, Iveta SELINGEROVÁ, Miluše VOZDOVÁ, Marek SVOBODA a Jiří RUBEŠ

Vydání

Neoplasma, Slovenská akademia vied, 2020, 0028-2685

Další údaje

Typ výsledku

Článek v odborném periodiku

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.575

DOI

http://dx.doi.org/10.4149/neo_2020_190604N485

Klíčová slova anglicky

breast cancer; gastrointestinal cancer; risk assessment; chromosome abberation; fluorescence in situ hybridisation

Štítky

RIV ne

Příznaky

Recenzováno

Změněno: 3. 8. 2020 08:04, Mgr. Tereza Miškechová

Anotace

V originále

Structural chromosome aberrations are a predictive biomarker of cancer risk. Conventional chromosome analysis widely used for these purposes detects unstable chromosome aberrations that are eliminated during cell division. Stable aberrations that may persist in the body and tend to accumulate during a lifetime can be detected by fluorescence in situ hybridization (FISH). The aim of the study was to investigate the level of chromosome damage in newly diagnosed cancer patients and control subjects by FISH. Both groups of untreated cancer patients had increased frequency of aberrant cells. However, chromosome damage affected different cytogenetic endpoints. Stable translocations and cells with complex rearrangements were elevated in breast cancer patients whereas unstable chromosome aberrations (dicentric chromosomes and acentric fragments) were elevated in gastrointestinal cancer patients. These associations observed in nonsmokers were typically not pronounced in smokers (with the exception of dicentric chromosomes in gastrointestinal patients). Exposure to tobacco smoke increased aberrations in healthy controls but not in the cancer patients. Our study suggests an association between cancer and stable chromosomal rearrangements in breast cancer patients. Unstable aberrations elevated in gastrointestinal cancer patients may be at least partly ascribed to the exposure to diagnostic X-rays.

Citovat

KADLČÍKOVÁ, Dita, Petra MUSILOVÁ, Hana HRADSKÁ, Markéta PETROVOVÁ, Iveta SELINGEROVÁ, Miluše VOZDOVÁ, Marek SVOBODA a Jiří RUBEŠ. Different chromosome damage in lymphocytes of newly diagnosed gastrointestinal and breast cancer patients. Neoplasma. Slovenská akademia vied, 2020, roč. 67, č. 3, s. 668-676. ISSN 0028-2685. Dostupné z: https://dx.doi.org/10.4149/neo_2020_190604N485.

@article{1623839,
   author = {Kadlčíková, Dita and Musilová, Petra and Hradská, Hana and Petrovová, Markéta and Selingerová, Iveta and Vozdová, Miluše and Svoboda, Marek and Rubeš, Jiří},
   article_number = {3},
   doi = {http://dx.doi.org/10.4149/neo_2020_190604N485},
   keywords = {breast cancer; gastrointestinal cancer; risk assessment; chromosome abberation; fluorescence in situ hybridisation},
   issn = {0028-2685},
   journal = {Neoplasma},
   note = {Bez afiliace k MU},
   title = {Different chromosome damage in lymphocytes of newly diagnosed gastrointestinal and breast cancer patients},
   volume = {67},
   year = {2020}
}

TY  - JOUR
ID  - 1623839
AU  - Kadlčíková, Dita - Musilová, Petra - Hradská, Hana - Petrovová, Markéta - Selingerová, Iveta - Vozdová, Miluše - Svoboda, Marek - Rubeš, Jiří
PY  - 2020
TI  - Different chromosome damage in lymphocytes of newly diagnosed gastrointestinal and breast cancer patients
JF  - Neoplasma
VL  - 67
IS  - 3
SP  - 668-676
EP  - 668-676
PB  - Slovenská akademia vied
SN  - 00282685
N1  - Bez afiliace k MU
KW  - breast cancer
KW  - gastrointestinal cancer
KW  - risk assessment
KW  - chromosome abberation
KW  - fluorescence in situ hybridisation
N2  - Structural chromosome aberrations are a predictive biomarker of cancer risk. Conventional chromosome analysis widely used for these purposes detects unstable chromosome aberrations that are eliminated during cell division. Stable aberrations that may persist in the body and tend to accumulate during a lifetime can be detected by fluorescence in situ hybridization (FISH). The aim of the study was to investigate the level of chromosome damage in newly diagnosed cancer patients and control subjects by FISH. Both groups of untreated cancer patients had increased frequency of aberrant cells. However, chromosome damage affected different cytogenetic endpoints. Stable translocations and cells with complex rearrangements were elevated in breast cancer patients whereas unstable chromosome aberrations (dicentric chromosomes and acentric fragments) were elevated in gastrointestinal cancer patients. These associations observed in nonsmokers were typically not pronounced in smokers (with the exception of dicentric chromosomes in gastrointestinal patients). Exposure to tobacco smoke increased aberrations in healthy controls but not in the cancer patients. Our study suggests an association between cancer and stable chromosomal rearrangements in breast cancer patients. Unstable aberrations elevated in gastrointestinal cancer patients may be at least partly ascribed to the exposure to diagnostic X-rays.
ER  -

KADLČÍKOVÁ, Dita, Petra MUSILOVÁ, Hana HRADSKÁ, Markéta PETROVOVÁ, Iveta SELINGEROVÁ, Miluše VOZDOVÁ, Marek SVOBODA a Jiří RUBEŠ. Different chromosome damage in lymphocytes of newly diagnosed gastrointestinal and breast cancer patients. \textit{Neoplasma}. Slovenská akademia vied, 2020, roč.~67, č.~3, s.~668-676. ISSN~0028-2685. Dostupné z: https://dx.doi.org/10.4149/neo\_{}2020\_{}190604N485.

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