Effect of impaired cardiac conduction after alcohol septal ablation on clinical outcomes: insights from the Euro-ASA registry

JENSEN, Morten Kvistholm, Lothar FABER, Max LIEBREGTS, Jaroslav JANUSKA, Jan KREJČÍ, Thomas BARTEL, Robert M. COOPER, Maciej DABROWSKI, Peter Riis HANSEN, Vibeke Marie ALMAAS, Hubert SEGGEWISS, Dieter HORSTKOTTE, Radka ADLOVA, Jurrien TEN BERG, Henning BUNDGAARD a Josef VESELKA. Effect of impaired cardiac conduction after alcohol septal ablation on clinical outcomes: insights from the Euro-ASA registry. EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES. OXFORD: OXFORD UNIV PRESS, 2019, roč. 5, č. 3, s. 252-258. ISSN 2058-5225. Dostupné z: https://dx.doi.org/10.1093/ehjqcco/qcy049.

Základní údaje

Originální název

Effect of impaired cardiac conduction after alcohol septal ablation on clinical outcomes: insights from the Euro-ASA registry

Autoři

JENSEN, Morten Kvistholm (208 Dánsko, garant), Lothar FABER (276 Německo), Max LIEBREGTS (528 Nizozemské království), Jaroslav JANUSKA (203 Česká republika), Jan KREJČÍ (203 Česká republika, domácí), Thomas BARTEL (40 Rakousko), Robert M. COOPER (826 Velká Británie a Severní Irsko), Maciej DABROWSKI (616 Polsko), Peter Riis HANSEN (208 Dánsko), Vibeke Marie ALMAAS (578 Norsko), Hubert SEGGEWISS (276 Německo), Dieter HORSTKOTTE (276 Německo), Radka ADLOVA (203 Česká republika), Jurrien TEN BERG (528 Nizozemské království), Henning BUNDGAARD (276 Německo) a Josef VESELKA (203 Česká republika)

Vydání

EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES, OXFORD, OXFORD UNIV PRESS, 2019, 2058-5225

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Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Slovinsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Kód RIV

RIV/00216224:14110/19:00112991

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1093/ehjqcco/qcy049

UT WoS

000493732200013

Klíčová slova anglicky

Hypertrophic cardiomyopathy; Alcohol septal ablation; Pacemaker; Implantable cardioverter-defibrillator; Bundle branch block; Cardiac conduction; Survival

Štítky

14110115, rivok

Příznaky

Mezinárodní význam, Recenzováno

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Anotace

V originále

Aims We analysed the impact of bundle branch block (BBB) and pacemaker (PM) implantation on symptoms and survival after alcohol septal ablation (ASA) in patients with hypertrophic cardiomyopathy (HCM). Methods and results Among 1416 HCM patients from the Euro-ASA registry, 58 (4%) patients had a PM and 64 (5%) patients had an implantable cardioverter-defibrillator (ICD) before ASA. At latest follow-up (5.0 +/- 4.0 years) after ASA, 118 (8%) patients had an ICD and 229 (16%) patients had a PM. In patients without an implantable device prior to ASA 13% had a PM and 5% had an ICD implanted following ASA. New onset BBB was present in 44% (right BBB in 31%) of patients without previous BBB. At latest follow-up, we found no associations between BBB and New York Heart Association (NYHA) Class 3-4 [odds ratio (OR) 0.98, 95% confidence interval (CI) 0.63-1.51; P = 0.91] or Canadian Cardiovascular Society (CCS) Class 3-4 (OR 1.5, CI 0.32-6.7; P = 0.62), respectively, and no associations between PM and NYHA Class 3-4 (OR 1.2, CI 0.70-2.0; P = 0.52) or CCS 3-4 (OR 1.3, CI 0.24-6.6; P = 0.79), respectively. The survival after ASA was not reduced in patients with BBB [hazard ratio (HR) 0.73, CI 0.53-1.01; P = 0.06] or PM (HR 0.78, CI 0.52-1.17; P = 0.24). Conclusions Development of BBB or need for a PM after ASA in patients with obstructive HCM was not associated with inferior symptomatic outcome or reduced survival, thus concerns for the negative impact of impaired cardiac conduction on the clinical outcome after ASA were not confirmed.