POSPÍŠILOVÁ, Veronika, Milan EŠNER, Iveta ČERVENKOVÁ, Radek FEDR, Jean-Yvez TINEVEZ, Aleš HAMPL a Martin ANGER. The frequency and consequences of multipolar mitoses in undifferentiated embryonic stem cells. Journal of applied biomedicine. České Budějovice: Faculty of Health and Social Care, University of South Bohemia, 2019, roč. 17, č. 4, s. 209-217. ISSN 1214-021X. Dostupné z: https://dx.doi.org/10.32725/jab.2019.018. |
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@article{1624157, author = {Pospíšilová, Veronika and Ešner, Milan and Červenková, Iveta and Fedr, Radek and Tinevez, JeanandYvez and Hampl, Aleš and Anger, Martin}, article_location = {České Budějovice}, article_number = {4}, doi = {http://dx.doi.org/10.32725/jab.2019.018}, keywords = {Embryonic stem (ES) cells; Mitosis length; Multipolar division; Single-cell tracking; Spindle assembly checkpoint (SAC); Time-lapse microscopy}, language = {eng}, issn = {1214-021X}, journal = {Journal of applied biomedicine}, title = {The frequency and consequences of multipolar mitoses in undifferentiated embryonic stem cells}, url = {http://dx.doi.org/10.32725/jab.2019.018}, volume = {17}, year = {2019} }
TY - JOUR ID - 1624157 AU - Pospíšilová, Veronika - Ešner, Milan - Červenková, Iveta - Fedr, Radek - Tinevez, Jean-Yvez - Hampl, Aleš - Anger, Martin PY - 2019 TI - The frequency and consequences of multipolar mitoses in undifferentiated embryonic stem cells JF - Journal of applied biomedicine VL - 17 IS - 4 SP - 209-217 EP - 209-217 PB - Faculty of Health and Social Care, University of South Bohemia SN - 1214021X KW - Embryonic stem (ES) cells KW - Mitosis length KW - Multipolar division KW - Single-cell tracking KW - Spindle assembly checkpoint (SAC) KW - Time-lapse microscopy UR - http://dx.doi.org/10.32725/jab.2019.018 L2 - http://dx.doi.org/10.32725/jab.2019.018 N2 - Embryonic stem (ES) cells are pluripotent cells widely used in cell therapy and tissue engineering. However, the broader clinical applications of ES cells are limited by their genomic instability and karyotypic abnormalities. Thus, understanding the mechanisms underlying ES cell karyotypic abnormalities is critical to optimizing their dinical use. In this study, we focused on proliferating human and mouse ES cells undergoing multipolar divisions. Specifically, we analyzed the frequency and outcomes of such divisions using a combination of time-lapse microscopy and cell tracking. This revealed that cells resulting from multipolar divisions were not only viable, but they also frequently underwent subsequent cell divisions. Our novel data also showed that in human and mouse ES cells, multipolar spindles allowed more robust escape from chromosome segregation control mechanisms than bipolar spindles. Considering the frequency of multipolar divisions in proliferating ES cells, it is conceivable that cell division errors underlie ES cell karyotypic instability. ER -
POSPÍŠILOVÁ, Veronika, Milan EŠNER, Iveta ČERVENKOVÁ, Radek FEDR, Jean-Yvez TINEVEZ, Aleš HAMPL a Martin ANGER. The frequency and consequences of multipolar mitoses in undifferentiated embryonic stem cells. \textit{Journal of applied biomedicine}. České Budějovice: Faculty of Health and Social Care, University of South Bohemia, 2019, roč.~17, č.~4, s.~209-217. ISSN~1214-021X. Dostupné z: https://dx.doi.org/10.32725/jab.2019.018.
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