2019
INSIGHT INTO "NUCLEAR-CYTOPLASMIC SHUTTLING" AS A DEVELOPMENTAL AND DIFFERENTIATIONAL CAPABILITY OF CELLS IN PRIMARY CULTURE MODELS
KULUS, M., M. BRAZERT, M. POPIS, B. BOROWIEC, D. BUKOWSKA et. al.Základní údaje
Originální název
INSIGHT INTO "NUCLEAR-CYTOPLASMIC SHUTTLING" AS A DEVELOPMENTAL AND DIFFERENTIATIONAL CAPABILITY OF CELLS IN PRIMARY CULTURE MODELS
Autoři
KULUS, M. (616 Polsko), M. BRAZERT (616 Polsko), M. POPIS (616 Polsko), B. BOROWIEC (616 Polsko), D. BUKOWSKA (616 Polsko), Michal JEŠETA (203 Česká republika, domácí), H. PIOTROWSKA-KEMPISTY (616 Polsko), M. NOWICKI (616 Polsko), B. KEMPISTY (616 Polsko, garant) a P. ANTOSIK (616 Polsko)
Vydání
Journal of biological regulators and homeostatic agents, Silva Marina, Biolife SAS, 2019, 0393-974X
Další údaje
Jazyk
angličtina
Typ výsledku
Článek v odborném periodiku
Obor
10601 Cell biology
Stát vydavatele
Itálie
Utajení
není předmětem státního či obchodního tajemství
Odkazy
Impakt faktor
Impact factor: 1.506
Kód RIV
RIV/00216224:14110/19:00113004
Organizační jednotka
Lékařská fakulta
UT WoS
000464697500019
Klíčová slova anglicky
primary cell model; in vitro growth and development; nuclear-cytoplasmic shuttling
Příznaky
Mezinárodní význam, Recenzováno
Změněno: 14. 4. 2020 14:25, Mgr. Tereza Miškechová
Anotace
V originále
Shuttling proteins are molecules that can facilitate transport through the nuclear envelope. A very large number of proteins are involved in this process that includes nuclear pore buildup, signal, receptor and enzyme proteins. There are many examples of proteins whose biological activity depends on nucleocytoplasmic transport. Very often they are largely responsible for the proper occurrence of cell division, maturation, development and differentiation. Thanks to the well mastered methods of in vitro cell culture, it is possible to trace the levels of protein expression and their distribution in cells. Advanced molecular techniques allow for precise determination of their displacement in time. Several studies are still being carried out, using primary cultures, to identify the factors that determine the maturation, development and differentiation of cells. In understanding of the detailed mechanisms controlling cell life, the key is not the level of expression of a specific protein, but its distribution in individual cellular compartments.