INSIGHT INTO "NUCLEAR-CYTOPLASMIC SHUTTLING" AS A DEVELOPMENTAL AND DIFFERENTIATIONAL CAPABILITY OF CELLS IN PRIMARY CULTURE MODELS

KULUS, M., M. BRAZERT, M. POPIS, B. BOROWIEC, D. BUKOWSKA, Michal JEŠETA, H. PIOTROWSKA-KEMPISTY, M. NOWICKI, B. KEMPISTY a P. ANTOSIK. INSIGHT INTO "NUCLEAR-CYTOPLASMIC SHUTTLING" AS A DEVELOPMENTAL AND DIFFERENTIATIONAL CAPABILITY OF CELLS IN PRIMARY CULTURE MODELS. Journal of biological regulators and homeostatic agents. Silva Marina: Biolife SAS, 2019, roč. 33, č. 1, s. 145-149. ISSN 0393-974X.

Základní údaje

Originální název

INSIGHT INTO "NUCLEAR-CYTOPLASMIC SHUTTLING" AS A DEVELOPMENTAL AND DIFFERENTIATIONAL CAPABILITY OF CELLS IN PRIMARY CULTURE MODELS

Autoři

KULUS, M. (616 Polsko), M. BRAZERT (616 Polsko), M. POPIS (616 Polsko), B. BOROWIEC (616 Polsko), D. BUKOWSKA (616 Polsko), Michal JEŠETA (203 Česká republika, domácí), H. PIOTROWSKA-KEMPISTY (616 Polsko), M. NOWICKI (616 Polsko), B. KEMPISTY (616 Polsko, garant) a P. ANTOSIK (616 Polsko)

Vydání

Journal of biological regulators and homeostatic agents, Silva Marina, Biolife SAS, 2019, 0393-974X

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Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10601 Cell biology

Stát vydavatele

Itálie

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 1.506

Kód RIV

RIV/00216224:14110/19:00113004

Organizační jednotka

Lékařská fakulta

UT WoS

000464697500019

Klíčová slova anglicky

primary cell model; in vitro growth and development; nuclear-cytoplasmic shuttling

Štítky

14110411, rivok

Příznaky

Mezinárodní význam, Recenzováno

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Anotace

V originále

Shuttling proteins are molecules that can facilitate transport through the nuclear envelope. A very large number of proteins are involved in this process that includes nuclear pore buildup, signal, receptor and enzyme proteins. There are many examples of proteins whose biological activity depends on nucleocytoplasmic transport. Very often they are largely responsible for the proper occurrence of cell division, maturation, development and differentiation. Thanks to the well mastered methods of in vitro cell culture, it is possible to trace the levels of protein expression and their distribution in cells. Advanced molecular techniques allow for precise determination of their displacement in time. Several studies are still being carried out, using primary cultures, to identify the factors that determine the maturation, development and differentiation of cells. In understanding of the detailed mechanisms controlling cell life, the key is not the level of expression of a specific protein, but its distribution in individual cellular compartments.