JEŠETA, Michal, Tomáš CRHA, Jana ŽÁKOVÁ and Pavel VENTRUBA. Bisfenoly v patologii reprodukce (Bisphenols in the pathology of reproduction). ČESKÁ GYNEKOLOGIE-CZECH GYNAECOLOGY. PRAGUE: NAKLADATELSKE STREDISKO C L S J E PURKYNE, 2019, vol. 84, No 2, p. 161-165. ISSN 1210-7832.
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Basic information
Original name Bisfenoly v patologii reprodukce
Name (in English) Bisphenols in the pathology of reproduction
Authors JEŠETA, Michal (203 Czech Republic, guarantor, belonging to the institution), Tomáš CRHA (203 Czech Republic, belonging to the institution), Jana ŽÁKOVÁ (203 Czech Republic, belonging to the institution) and Pavel VENTRUBA (203 Czech Republic, belonging to the institution).
Edition ČESKÁ GYNEKOLOGIE-CZECH GYNAECOLOGY, PRAGUE, NAKLADATELSKE STREDISKO C L S J E PURKYNE, 2019, 1210-7832.
Other information
Original language Czech
Type of outcome Article in a journal
Field of Study 30214 Obstetrics and gynaecology
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
WWW URL
RIV identification code RIV/00216224:14110/19:00113140
Organization unit Faculty of Medicine
UT WoS 000473263800012
Keywords (in Czech) bisfenol; reprodukce; endokrinní disruptor; oocyt; spermie
Keywords in English bisphenol; reproduction; endocrine disruptor; oocyte; spermatozoa
Tags 14110411, rivok
Tags Reviewed
Changed by Changed by: Mgr. Tereza Miškechová, učo 341652. Changed: 14/4/2020 14:20.
Abstract
Název a sídlo pracoviště: Gynekologicko-porodnická klinika Lékařské fakulty Masarykovy univerzity a FN Brno. Metodika: Literární rešerše databáze PubMed publikované do října 2018 s termíny zaměřenými na „bisphenol“ a „reproduction“. Výsledky: V lidských tkáních a tělesných tekutinách byly prokázány vyšší koncentrace bisfenolu A a S. Molekuly bisfenolů mají účinek analogický estrogenům, ovlivňují hormonální regulaci a aktivitu estrogenových receptorů. Byl prokázán jejich vliv na poruchy maturace oocytů, spermatogenezi a vývoj reprodukčního ústrojí. Bisfenol S má negativní účinky na reprodukci srovnatelné s bisfenolem A, který ve výrobě nahradil. Závěr: Bisfenoly jsou rozšířené endokrinní disruptory, které mohou vyvolat závažné poruchy plodnosti žen i mužů.
Abstract (in English)
Objective: Bisphenols are one of the most widespread endocrine disruptors that the population of west world countries is exposed to. Objective of this study is to summarize information about influence of bisphenols on reproduction health. Design: Review article. Setting: Department of Obstetrics and Gynecology, Faculty of Medicine, Masaryk University and University Hospital Brno. Methods: PubMed was searched for articles in English indexed bisphenol and reproduction up to October 2018. Results: Increased levels of bisphenol A and S have been proven in body fluids and tissues. Bisphenol molecules have effect similar to estrogens therefore they influence hormonal regulation and activity of estrogen receptors. Their negative influence on oocyte maturation, spermatogenesis and development of reproductive system has been shown. Bisphenol S, which has replaced bisphenol A, has comparable negative effects on reproduction. Conclusion: Bisphenols are widespread endocrine disruptors that could cause severe fertility disorders of men and women.
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