2016
Mouse Lipocalins (MUP, OBP, LCN) Are Co-expressed in Tissues Involved in Chemical Communication
STOPKOVA, Romana, David VINKLER, Barbora KUNTOVA, Ondrej ŠEDO, Tomáš ALBRECHT et. al.Základní údaje
Originální název
Mouse Lipocalins (MUP, OBP, LCN) Are Co-expressed in Tissues Involved in Chemical Communication
Autoři
STOPKOVA, Romana, David VINKLER, Barbora KUNTOVA, Ondrej ŠEDO (203 Česká republika, garant, domácí), Tomáš ALBRECHT (203 Česká republika), Jan SUCHAN, Katerina DVORAKOVA-HORTOVA, Zbyněk ZDRÁHAL (203 Česká republika, domácí) a Pavel STOPKA (203 Česká republika)
Vydání
FRONTIERS IN ECOLOGY AND EVOLUTION, LAUSANNE, FRONTIERS MEDIA SA, 2016, 2296-701X
Další údaje
Jazyk
angličtina
Typ výsledku
Článek v odborném periodiku
Obor
10600 1.6 Biological sciences
Stát vydavatele
Švýcarsko
Utajení
není předmětem státního či obchodního tajemství
Odkazy
Kód RIV
RIV/00216224:14310/16:00108174
Organizační jednotka
Přírodovědecká fakulta
UT WoS
000517761700047
Klíčová slova anglicky
lipocalin; odorant; chemical communication; Mus musculus; olfaction
Štítky
Příznaky
Mezinárodní význam, Recenzováno
Změněno: 24. 4. 2020 12:49, Mgr. Pavla Foltynová, Ph.D.
Anotace
V originále
Chemical communication is mediated by signal production and signal perception and in house mice (Mus musculus), both processes involve lipocalin proteins (OBP, MUP, LCN) that transport volatiles and protect them in tissues where they are produced. However, potential roles of lacrimal, nasal, and salivary lipocalins are still not well known. We aimed to determine the expression of the recently described family of odorant binding proteins (Obp), along with major urinary proteins (Mup) across different tissues in wild mice (Mus musculus) to assess the importance of these proteins based on their quantity in particular expression sites. We performed qPCR analysis of selected Mup, Lcn, Obp genes, and predicted Obp members to study their expression in selected tissues. We identified new members of the mouse odorant binding protein gene family in two subspecies, M. m. musculus and M. m. dornesticus. We show that Mup4 and Mupb from the phylogenetically older group-A are co-expressed with Obps in orofacial tissues. We also identified a sexually dimorphic pattern of female-biased Obp7 and male-biased Mup4 expression in lacrimal glands. OBPs, MUPs, and LCNs are produced in parallel, which may function to widen the spectrum of bound ligands, potentially including the degradation products of olfactory signals and/or toxic compounds. Moreover, our study demonstrates that several pheromone transporters from the lipocalin family are co-expressed in the nasal and lacrimal tissues of mice with the newly detected OBPs that further expand the already diverse mouse lipocalin family.
Návaznosti
ED1.1.00/02.0068, projekt VaV |
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GBP206/12/G151, projekt VaV |
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