Detailed Information on Publication Record
2020
Gene variability in matrix metalloproteinases in patients with recurrent aphthous stomatitis
SLEZÁKOVÁ, Simona, Petra BOŘILOVÁ LINHARTOVÁ, Jirina BARTOVA, Jitka PETANOVA, Pavel KUKLINEK et. al.Basic information
Original name
Gene variability in matrix metalloproteinases in patients with recurrent aphthous stomatitis
Authors
SLEZÁKOVÁ, Simona (203 Czech Republic, belonging to the institution), Petra BOŘILOVÁ LINHARTOVÁ (203 Czech Republic, belonging to the institution), Jirina BARTOVA (203 Czech Republic), Jitka PETANOVA (203 Czech Republic), Pavel KUKLINEK (203 Czech Republic), Antonín FASSMANN (203 Czech Republic, belonging to the institution), Ladislav DUŠEK (203 Czech Republic, belonging to the institution) and Lydie IZAKOVIČOVÁ HOLLÁ (203 Czech Republic, guarantor, belonging to the institution)
Edition
JOURNAL OF ORAL PATHOLOGY & MEDICINE, HOBOKEN, WILEY, 2020, 0904-2512
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30208 Dentistry, oral surgery and medicine
Country of publisher
United States of America
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 4.253
RIV identification code
RIV/00216224:14110/20:00115430
Organization unit
Faculty of Medicine
UT WoS
000511596800001
Keywords in English
case-control study; matrix metalloproteinase; polymorphism; recurrent aphthous stomatitis
Tags
International impact, Reviewed
Změněno: 20/3/2020 09:41, Mgr. Tereza Miškechová
Abstract
V originále
Background The development of recurrent aphthous stomatitis (RAS), inflammatory disease of oral mucosa, is influenced by both environmental and genetic factors. The aim of this study was to investigate polymorphisms located in seven genes coding different types of matrix metalloproteinases (MMPs)-collagenases (MMP1, MMP8, and MMP13), gelatinases (MMP2 and MMP9), stromelysin (MMP3), and membrane-type metalloproteinase (MMP16) in patients with RAS and healthy controls. Methods Totally, 223 subjects were included in this case-control study and their detailed anamnestic, clinical, and laboratory parameters were recorded. Seventy-seven patients with RAS and 146 controls were genotyped for seventeen polymorphisms in the MMPs genes using the real-time polymerase chain reaction (PCR) or PCR with restriction analysis. Results Allele, genotype, and haplotype frequencies of the studied polymorphisms between RAS patients and controls were similar, except for allele distributions of MMP1 rs1144393, MMP9 rs3918242, and MMP16 rs10429371, which were different between patients with RAS and healthy controls (P = .023, P = .049 and P = .025, all P-corr > 0.05, respectively). Moreover, the comparison of genotype frequencies (TT vs CC + CT) of the MMP16 rs10429371 variant showed a marginally significant difference between RAS patients and controls (P = .05, P-corr > 0.05, OR = 1.68, 95% CI = 0.95-2.98). Conclusions No significant relationship between investigated polymorphisms in seven MMPs genes and RAS development in the Czech population was observed in this study.
Links
| MUNI/A/1546/2018, interní kód MU |
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