Epoxidation is the preferred pathway of first-stage metabolism
of abiraterone acetate in brown bullhead (Ameiurus nebulosus)

J 2019

Epoxidation is the preferred pathway of first-stage metabolism of abiraterone acetate in brown bullhead (Ameiurus nebulosus)

MACH, Samuel, A. JEGOROV, M. KUZMA, J. ZAPAL, Zdeněk ŠIMEK et. al.

Základní údaje

Originální název

Epoxidation is the preferred pathway of first-stage metabolism of abiraterone acetate in brown bullhead (Ameiurus nebulosus)

Autoři

MACH, Samuel (203 Česká republika, domácí), A. JEGOROV, M. KUZMA, J. ZAPAL, Zdeněk ŠIMEK (203 Česká republika, garant, domácí), J. CEJKA a V. EIGNER

Vydání

Environmental Science and Pollution Research, Heidelberg, Springer Heidelberg, 2019, 0944-1344

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10511 Environmental sciences

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.056

Kód RIV

RIV/00216224:14310/19:00113379

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1007/s11356-019-06568-y

UT WoS

000492722200002

Klíčová slova anglicky

Abiraterone acetate; Metabolites; Fish; Epoxidation; Ameiurus nebulosus; HPLC; MS; NMR

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 3. 4. 2020 13:49, Mgr. Marie Šípková, DiS.

Anotace

V originále

Twenty juvenile individuals of brown bullhead (Ameiurus nebulosus), average weight 77 g, were fed by abiraterone acetate prodrug dissolved in olive oil via gastric probe. Dose applied was 3 mg/10 g fish weight. After feeding, they were let out into aquarium and kept there for 3 days. Aquarium water containing excreted metabolites was extracted, and sample was purified and finally analyzed by means of HPLC/MS. Expected both primary (products of hydroxylation) and secondary (products of glucuronidation and sulfatation) metabolites of abiraterone acetate were identified. The NMR measurement of one of the prevailing metabolites presumed to be one of possible hydroxy-abiraterones discovered that it is not hydroxy-abiraterone but abiraterone 16,17-epoxide. Closer analysis of MS2 and MS3 spectra revealed that one of presumed hydroxy-abiraterone acetates and also some secondary metabolites are probably 16,17-epoxides.

Návaznosti

EF16_013/0001761, projekt VaV

Název: RECETOX RI

LM2015051, projekt VaV

Název: Centrum pro výzkum toxických látek v prostředí (Akronym: RECETOX RI)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Výzkumná infrastruktura RECETOX

Citovat

MACH, Samuel, A. JEGOROV, M. KUZMA, J. ZAPAL, Zdeněk ŠIMEK, J. CEJKA a V. EIGNER. Epoxidation is the preferred pathway of first-stage metabolism of abiraterone acetate in brown bullhead (Ameiurus nebulosus). Environmental Science and Pollution Research. Heidelberg: Springer Heidelberg, 2019, roč. 26, č. 34, s. 34896-34904. ISSN 0944-1344. Dostupné z: https://dx.doi.org/10.1007/s11356-019-06568-y.

@article{1639996,
   author = {Mach, Samuel and Jegorov, A. and Kuzma, M. and Zapal, J. and Šimek, Zdeněk and Cejka, J. and Eigner, V.},
   article_location = {Heidelberg},
   article_number = {34},
   doi = {http://dx.doi.org/10.1007/s11356-019-06568-y},
   keywords = {Abiraterone acetate; Metabolites; Fish; Epoxidation; Ameiurus nebulosus; HPLC; MS; NMR},
   language = {eng},
   issn = {0944-1344},
   journal = {Environmental Science and Pollution Research},
   title = {Epoxidation is the preferred pathway of first-stage metabolism of abiraterone acetate in brown bullhead (Ameiurus nebulosus)},
   url = {http://dx.doi.org/10.1007/s11356-019-06568-y},
   volume = {26},
   year = {2019}
}

TY  - JOUR
ID  - 1639996
AU  - Mach, Samuel - Jegorov, A. - Kuzma, M. - Zapal, J. - Šimek, Zdeněk - Cejka, J. - Eigner, V.
PY  - 2019
TI  - Epoxidation is the preferred pathway of first-stage metabolism of abiraterone acetate in brown bullhead (Ameiurus nebulosus)
JF  - Environmental Science and Pollution Research
VL  - 26
IS  - 34
SP  - 34896-34904
EP  - 34896-34904
PB  - Springer Heidelberg
SN  - 09441344
KW  - Abiraterone acetate
KW  - Metabolites
KW  - Fish
KW  - Epoxidation
KW  - Ameiurus nebulosus
KW  - HPLC
KW  - MS
KW  - NMR
UR  - http://dx.doi.org/10.1007/s11356-019-06568-y
L2  - http://dx.doi.org/10.1007/s11356-019-06568-y
N2  - Twenty juvenile individuals of brown bullhead (Ameiurus nebulosus), average weight 77 g, were fed by abiraterone acetate prodrug dissolved in olive oil via gastric probe. Dose applied was 3 mg/10 g fish weight. After feeding, they were let out into aquarium and kept there for 3 days. Aquarium water containing excreted metabolites was extracted, and sample was purified and finally analyzed by means of HPLC/MS. Expected both primary (products of hydroxylation) and secondary (products of glucuronidation and sulfatation) metabolites of abiraterone acetate were identified. The NMR measurement of one of the prevailing metabolites presumed to be one of possible hydroxy-abiraterones discovered that it is not hydroxy-abiraterone but abiraterone 16,17-epoxide. Closer analysis of MS2 and MS3 spectra revealed that one of presumed hydroxy-abiraterone acetates and also some secondary metabolites are probably 16,17-epoxides.
ER  -

MACH, Samuel, A. JEGOROV, M. KUZMA, J. ZAPAL, Zdeněk ŠIMEK, J. CEJKA a V. EIGNER. Epoxidation is the preferred pathway of first-stage metabolism of abiraterone acetate in brown bullhead (Ameiurus nebulosus). \textit{Environmental Science and Pollution Research}. Heidelberg: Springer Heidelberg, 2019, roč.~26, č.~34, s.~34896-34904. ISSN~0944-1344. Dostupné z: https://dx.doi.org/10.1007/s11356-019-06568-y.

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