Global analysis and validation of miRNA levels in cerebrospinal fluid of brain tumor patients

KOPKOVÁ, Alena, Jiří ŠÁNA, Marek VEČEŘA, Táňa MACHÁČKOVÁ, Pavel FADRUS, Júlia BOHOŠOVÁ and Ondřej SLABÝ. Global analysis and validation of miRNA levels in cerebrospinal fluid of brain tumor patients. In AACR Annual Meeting on Bioinformatics, Convergence Science, and Systems Biology. 2019. ISSN 0008-5472. Available from: https://dx.doi.org/10.1158/1538-7445.AM2019-1806.

Basic information

• Original name: Global analysis and validation of miRNA levels in cerebrospinal fluid of brain tumor patients
• Authors: KOPKOVÁ, Alena (203 Czech Republic, belonging to the institution), Jiří ŠÁNA (203 Czech Republic, belonging to the institution), Marek VEČEŘA (703 Slovakia, belonging to the institution), Táňa MACHÁČKOVÁ (203 Czech Republic, belonging to the institution), Pavel FADRUS (203 Czech Republic, belonging to the institution), Júlia BOHOŠOVÁ (703 Slovakia, belonging to the institution) and Ondřej SLABÝ (203 Czech Republic, guarantor, belonging to the institution).
• Edition: AACR Annual Meeting on Bioinformatics, Convergence Science, and Systems Biology, 2019.

Other information

• Original language: English
• Type of outcome: Conference abstract
• Field of Study: 30204 Oncology
• Country of publisher: United States of America
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 9.727
• RIV identification code: RIV/00216224:14740/19:00108211
• Organization unit: Central European Institute of Technology
• ISSN: 0008-5472
• Doi: http://dx.doi.org/10.1158/1538-7445.AM2019-1806
• UT WoS: 000488129904327
• Keywords in English: miRNA; brain tumor
• Tags: rivok
• Tags: International impact

Abstract

Incidence rate of primary brain tumors and brain metastases counts yearly around 40 patients per 100 000 persons in the world and is still growing. Prognosis and therapy differs between brain tumor types and, therefore, accurate and early diagnosis might improve survival and life quality of patients. However, current diagnostic approaches are limited by localization and tissue heterogeneity of brain tumors. Cerebrospinal fluid (CSF) bathes central nervous system (CNS) and thus is supposed to reflect all pathological conditions. From this perspective, CSF looks as ideal source of diagnostic biomarkers of brain tumors. MicroRNAs, short non-coding RNAs involved in the pathogenesis of many cancers including brain tumors, might represent group of new biomarkers. In addition, dysregulated levels of brain tumor specific miRNAs have been already observed also in CSF. Following these facts, analysis of CSF miRNAs in brain tumor patients promises a new diagnostic approach enabling more accurate diagnosis.

Links

• GA17-17636S, research and development project: Name: Identifikace nových prognostických markerů a terapeutických cílových molekul u sarkomu měkkých tkání

Investor: Czech Science Foundation

• LQ1601, research and development project: Name: CEITEC 2020 (Acronym: CEITEC2020)

Investor: Ministry of Education, Youth and Sports of the CR

• NV18-03-00398, research and development project: Name: Rozšíření současných prognostických skórovacích systémů u mozkových metastáz o mikroRNA profilování s cílem individualizace pooperační péče

Investor: Ministry of Health of the CR, Extension of established prognostic scores in brain metastases by microRNA profiling to tailor the post-operative personalized care