Cell-free microRNAs as Non-invasive Diagnostic and Prognostic
Biomarkers in Pancreatic Cancer

J 2019

Cell-free microRNAs as Non-invasive Diagnostic and Prognostic Biomarkers in Pancreatic Cancer

GABŁO, Natalia Anna, Vladimír PROCHÁZKA, Zdeněk KALA, Ondřej SLABÝ, I. KISS et. al.

Základní údaje

Originální název

Cell-free microRNAs as Non-invasive Diagnostic and Prognostic Biomarkers in Pancreatic Cancer

Autoři

GABŁO, Natalia Anna (616 Polsko, domácí), Vladimír PROCHÁZKA (203 Česká republika, domácí), Zdeněk KALA (203 Česká republika, domácí), Ondřej SLABÝ (203 Česká republika, garant, domácí) a I. KISS

Vydání

CURRENT GENOMICS, SHARJAH, BENTHAM SCIENCE PUBL LTD, 2019, 1389-2029

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10608 Biochemistry and molecular biology

Stát vydavatele

Spojené arabské emiráty

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.630

Kód RIV

RIV/00216224:14740/19:00108614

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.2174/1389202921666191217095017

UT WoS

000509467300005

Klíčová slova anglicky

Cell-free microRNA; pancreatic cancer; diagnosis; prognosis; prediction; non-invasive biomarker

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 1. 4. 2020 12:03, Mgr. Pavla Foltynová, Ph.D.

Anotace

V originále

Pancreatic cancer (PaC) is one of the most lethal cancers, with an increasing global incidence rate. Unfavorable prognosis largely results from associated difficulties in early diagnosis and the absence of prognostic and predictive biomarkers that would enable an individualized therapeutic approach. In fact, PaC prognosis has not improved for years, even though much efforts and resources have been devoted to PaC research, and the multimodal management of PaC patients has been used in clinical practice. It is thus imperative to develop optimal biomarkers, which would increase diagnostic precision and improve the post-diagnostic management of PaC patients. Current trends in biomarker research envisage the unique opportunity of cell-free microRNAs (miRNAs) present in circulation to become a convenient, non-invasive tool for accurate diagnosis, prognosis and prediction of response to treatment. This review analyzes studies focused on cell-free miRNAs in PaC. The studies provide solid evidence that miRNAs are detectable in serum, blood plasma, saliva, urine, and stool, and that they present easy-to-acquire biomarkers with strong diagnostic, prognostic and predictive potential.

Návaznosti

NV16-31314A, projekt VaV

Název: Identifikace cirkulujících mikroRNA umožňujících prognostickou stratifikaci a selekci pacientů nejvíce profitujících z chirurgické léčby

Citovat

GABŁO, Natalia Anna, Vladimír PROCHÁZKA, Zdeněk KALA, Ondřej SLABÝ a I. KISS. Cell-free microRNAs as Non-invasive Diagnostic and Prognostic Biomarkers in Pancreatic Cancer. CURRENT GENOMICS. SHARJAH: BENTHAM SCIENCE PUBL LTD, 2019, roč. 20, č. 8, s. 569-580. ISSN 1389-2029. Dostupné z: https://dx.doi.org/10.2174/1389202921666191217095017.

@article{1641554,
   author = {Gabło, Natalia Anna and Procházka, Vladimír and Kala, Zdeněk and Slabý, Ondřej and Kiss, I.},
   article_location = {SHARJAH},
   article_number = {8},
   doi = {http://dx.doi.org/10.2174/1389202921666191217095017},
   keywords = {Cell-free microRNA; pancreatic cancer; diagnosis; prognosis; prediction; non-invasive biomarker},
   language = {eng},
   issn = {1389-2029},
   journal = {CURRENT GENOMICS},
   title = {Cell-free microRNAs as Non-invasive Diagnostic and Prognostic Biomarkers in Pancreatic Cancer},
   url = {http://www.eurekaselect.com/177563/article},
   volume = {20},
   year = {2019}
}

TY  - JOUR
ID  - 1641554
AU  - Gabło, Natalia Anna - Procházka, Vladimír - Kala, Zdeněk - Slabý, Ondřej - Kiss, I.
PY  - 2019
TI  - Cell-free microRNAs as Non-invasive Diagnostic and Prognostic Biomarkers in Pancreatic Cancer
JF  - CURRENT GENOMICS
VL  - 20
IS  - 8
SP  - 569-580
EP  - 569-580
PB  - BENTHAM SCIENCE PUBL LTD
SN  - 13892029
KW  - Cell-free microRNA
KW  - pancreatic cancer
KW  - diagnosis
KW  - prognosis
KW  - prediction
KW  - non-invasive biomarker
UR  - http://www.eurekaselect.com/177563/article
L2  - http://www.eurekaselect.com/177563/article
N2  - Pancreatic cancer (PaC) is one of the most lethal cancers, with an increasing global incidence rate. Unfavorable prognosis largely results from associated difficulties in early diagnosis and the absence of prognostic and predictive biomarkers that would enable an individualized therapeutic approach. In fact, PaC prognosis has not improved for years, even though much efforts and resources have been devoted to PaC research, and the multimodal management of PaC patients has been used in clinical practice. It is thus imperative to develop optimal biomarkers, which would increase diagnostic precision and improve the post-diagnostic management of PaC patients. Current trends in biomarker research envisage the unique opportunity of cell-free microRNAs (miRNAs) present in circulation to become a convenient, non-invasive tool for accurate diagnosis, prognosis and prediction of response to treatment. This review analyzes studies focused on cell-free miRNAs in PaC. The studies provide solid evidence that miRNAs are detectable in serum, blood plasma, saliva, urine, and stool, and that they present easy-to-acquire biomarkers with strong diagnostic, prognostic and predictive potential.
ER  -

GABŁO, Natalia Anna, Vladimír PROCHÁZKA, Zdeněk KALA, Ondřej SLABÝ a I. KISS. Cell-free microRNAs as Non-invasive Diagnostic and Prognostic Biomarkers in Pancreatic Cancer. \textit{CURRENT GENOMICS}. SHARJAH: BENTHAM SCIENCE PUBL LTD, 2019, roč.~20, č.~8, s.~569-580. ISSN~1389-2029. Dostupné z: https://dx.doi.org/10.2174/1389202921666191217095017.

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