Anterior thalamic deep brain stimulation in epilepsy and
persistent psychiatric side effects following discontinuation

J 2019

Anterior thalamic deep brain stimulation in epilepsy and persistent psychiatric side effects following discontinuation

DOLEŽALOVÁ, Irena, Jonáš KUNST, Martin KOJAN, Jan CHRASTINA, Marek BALÁŽ et. al.

Základní údaje

Originální název

Anterior thalamic deep brain stimulation in epilepsy and persistent psychiatric side effects following discontinuation

Autoři

DOLEŽALOVÁ, Irena (203 Česká republika, domácí), Jonáš KUNST (203 Česká republika, domácí), Martin KOJAN (703 Slovensko, domácí), Jan CHRASTINA (203 Česká republika, domácí), Marek BALÁŽ (703 Slovensko, domácí) a Milan BRÁZDIL (203 Česká republika, garant, domácí)

Vydání

Epilepsy and Behavior Reports, Netherlands, Elsevier BV, 2019, 2589-9864

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30210 Clinical neurology

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Kód RIV

RIV/00216224:14110/19:00108623

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1016/j.ebr.2019.100344

UT WoS

000566534900006

Klíčová slova anglicky

Case report; Deep brain stimulation of the anterior nucleus of the thalamus

Štítky

14110127, 14110131, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 14. 6. 2021 09:04, Mgr. Tereza Miškechová

Anotace

V originále

We report a case of a patient with drug-resistant epilepsy treated with deep brain stimulation of the anterior nucleus of the thalamus (ANT-DBS). The patient developed psychiatric side effects (PSEs), namely irritability, hostility, aggressiveness, and paranoia, after implantation and stimulation initiation. The stimulation was discontinued and the PSEs were mitigated, but the patient did not return to her pre-implantation state, as documented by repeated psychiatric reports and hospitalizations. To our knowledge, this is the first report of a patient who developed long-term PSEs that did not disappear after stimulation discontinuation. We suppose that ANT-DBS caused a persistent perturbation of the thalamic neuronal networks that are responsible for long-term PSEs.

Návaznosti

NV19-04-00343, projekt VaV

Název: Predikce Efektu Stimulace u pacientů s Epilepsií (PRESEnCE) (Akronym: PRESEnCE)

Investor: Ministerstvo zdravotnictví ČR, Prediction of Stimulation Efficacy in Epilepsy

Citovat

DOLEŽALOVÁ, Irena, Jonáš KUNST, Martin KOJAN, Jan CHRASTINA, Marek BALÁŽ a Milan BRÁZDIL. Anterior thalamic deep brain stimulation in epilepsy and persistent psychiatric side effects following discontinuation. Epilepsy and Behavior Reports. Netherlands: Elsevier BV, 2019, roč. 12, č. 2019, s. 1-3. ISSN 2589-9864. Dostupné z: https://dx.doi.org/10.1016/j.ebr.2019.100344.

@article{1643319,
   author = {Doležalová, Irena and Kunst, Jonáš and Kojan, Martin and Chrastina, Jan and Baláž, Marek and Brázdil, Milan},
   article_location = {Netherlands},
   article_number = {2019},
   doi = {http://dx.doi.org/10.1016/j.ebr.2019.100344},
   keywords = {Case report; Deep brain stimulation of the anterior nucleus of the thalamus},
   language = {eng},
   issn = {2589-9864},
   journal = {Epilepsy and Behavior Reports},
   title = {Anterior thalamic deep brain stimulation in epilepsy and persistent psychiatric side effects following discontinuation},
   url = {https://www.sciencedirect.com/science/article/pii/S2589986419301297?via%3Dihub},
   volume = {12},
   year = {2019}
}

TY  - JOUR
ID  - 1643319
AU  - Doležalová, Irena - Kunst, Jonáš - Kojan, Martin - Chrastina, Jan - Baláž, Marek - Brázdil, Milan
PY  - 2019
TI  - Anterior thalamic deep brain stimulation in epilepsy and persistent psychiatric side effects following discontinuation
JF  - Epilepsy and Behavior Reports
VL  - 12
IS  - 2019
SP  - 1-3
EP  - 1-3
PB  - Elsevier BV
SN  - 25899864
KW  - Case report
KW  - Deep brain stimulation of the anterior nucleus of the thalamus
UR  - https://www.sciencedirect.com/science/article/pii/S2589986419301297?via%3Dihub
L2  - https://www.sciencedirect.com/science/article/pii/S2589986419301297?via%3Dihub
N2  - We report a case of a patient with drug-resistant epilepsy treated with deep brain stimulation of the anterior nucleus of the thalamus (ANT-DBS). The patient developed psychiatric side effects (PSEs), namely irritability, hostility, aggressiveness, and paranoia, after implantation and stimulation initiation. The stimulation was discontinued and the PSEs were mitigated, but the patient did not return to her pre-implantation state, as documented by repeated psychiatric reports and hospitalizations. To our knowledge, this is the first report of a patient who developed long-term PSEs that did not disappear after stimulation discontinuation. We suppose that ANT-DBS caused a persistent perturbation of the thalamic neuronal networks that are responsible for long-term PSEs.
ER  -

DOLEŽALOVÁ, Irena, Jonáš KUNST, Martin KOJAN, Jan CHRASTINA, Marek BALÁŽ a Milan BRÁZDIL. Anterior thalamic deep brain stimulation in epilepsy and persistent psychiatric side effects following discontinuation. \textit{Epilepsy and Behavior Reports}. Netherlands: Elsevier BV, 2019, roč.~12, č.~2019, s.~1-3. ISSN~2589-9864. Dostupné z: https://dx.doi.org/10.1016/j.ebr.2019.100344.

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