Observational Study of Platelet Reactivity in Patients
Presenting With ST-Segment Elevation Myocardial Infarction Due
to Coronary Stent Thrombosis Undergoing Primary Percutaneous
Coronary Intervention Results From the European PREvention of
Stent Thrombosis by an Interdisciplinary Global European Effort
Registry

J 2017

Observational Study of Platelet Reactivity in Patients Presenting With ST-Segment Elevation Myocardial Infarction Due to Coronary Stent Thrombosis Undergoing Primary Percutaneous Coronary Intervention Results From the European PREvention of Stent Thrombosis by an Interdisciplinary Global European Effort Registry

GODSCHALK, T. C., R. A. BYRNE, T. ADRIAENSSENS, N. MALIK, L. J. FELDMAN et. al.

Základní údaje

Originální název

Observational Study of Platelet Reactivity in Patients Presenting With ST-Segment Elevation Myocardial Infarction Due to Coronary Stent Thrombosis Undergoing Primary Percutaneous Coronary Intervention Results From the European PREvention of Stent Thrombosis by an Interdisciplinary Global European Effort Registry

Autoři

GODSCHALK, T. C. (528 Nizozemské království), R. A. BYRNE (276 Německo), T. ADRIAENSSENS (56 Belgie), N. MALIK (826 Velká Británie a Severní Irsko), L. J. FELDMAN (250 Francie), G. GUAGLIUMI (380 Itálie), F. ALFONSO (724 Španělsko), F. J. NEUMANN (276 Německo), D. TRENK (276 Německo), M. JONER (276 Německo), C. SCHULZ (276 Německo), P. G. STEG (250 Francie), A. H. GOODALL (826 Velká Británie a Severní Irsko), R. WOJDYLA (616 Polsko), D. DUDEK (616 Polsko), J. J. WYKRZYKOWSKA (528 Nizozemské království), Ota HLINOMAZ (203 Česká republika, domácí), A. G. ZAMAN (826 Velká Británie a Severní Irsko), N. CURZEN (826 Velká Británie a Severní Irsko), J. DENS (56 Belgie), P. SINNAEVE (56 Belgie), W. DESMET (56 Belgie), A. H. GERSHLICK (826 Velká Británie a Severní Irsko), A. KASTRATI (276 Německo), S. MASSBERG (276 Německo) a J. M. TEN BERG (528 Nizozemské království, garant)

Vydání

JACC - Cardiovascular Interventions, New York, Elsevier Science Inc. 2017, 1936-8798

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 9.881

Kód RIV

RIV/00216224:14110/17:00113800

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1016/j.jcin.2017.09.019

UT WoS

000418483200014

Klíčová slova anglicky

aspirin; platelet aggregation; platelet function tests; P2Y(12) receptor antagonists; stent thrombosis

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 27. 4. 2020 13:18, Mgr. Tereza Miškechová

Anotace

V originále

OBJECTIVES High platelet reactivity (HPR) was studied in patients presenting with ST-segment elevation myocardial infarction (STEMI) due to stent thrombosis (ST) undergoing immediate percutaneous coronary intervention (PCI). BACKGROUND HPR on P2Y12 inhibitors (HPR-ADP) is frequently observed in stable patients who have experienced ST. The HPR rates in patients presenting with ST for immediate PCI are unknown. METHODS Consecutive patients presenting with definite ST were included in a multicenter ST registry. Platelet reactivity was measured before immediate PCI with the VerifyNow P2Y12 or Aspirin assay. RESULTS Platelet reactivity was measured in 129 ST patients presenting with STEMI undergoing immediate PCI. HPR-ADP was observed in 76% of the patients, and HPR on aspirin (HPR-AA) was observed in 13% of the patients. HPR rates were similar in patients who were on maintenance P2Y12 inhibitor or aspirin since stent placement versus those without these medications. In addition, HPR-ADP was similar in patients loaded with a P2Y12 inhibitor shortly before immediate PCI versus those who were not. In contrast, HPR-AA trended to be lower in patients loaded with aspirin as compared with those not loaded. CONCLUSIONS Approximately 3 out of 4 ST patients with STEMI undergoing immediate PCI had HPR-ADP, and 13% had HPR-AA. Whether patients were on maintenance antiplatelet therapy while developing ST or loaded with P2Y12 inhibitors shortly before undergoing immediate PCI had no influence on the HPR rates. This raises concerns that the majority of patients with ST have suboptimal platelet inhibition undergoing immediate PCI. (C) 2017 by the American College of Cardiology Foundation.

Citovat

GODSCHALK, T. C., R. A. BYRNE, T. ADRIAENSSENS, N. MALIK, L. J. FELDMAN, G. GUAGLIUMI, F. ALFONSO, F. J. NEUMANN, D. TRENK, M. JONER, C. SCHULZ, P. G. STEG, A. H. GOODALL, R. WOJDYLA, D. DUDEK, J. J. WYKRZYKOWSKA, Ota HLINOMAZ, A. G. ZAMAN, N. CURZEN, J. DENS, P. SINNAEVE, W. DESMET, A. H. GERSHLICK, A. KASTRATI, S. MASSBERG a J. M. TEN BERG. Observational Study of Platelet Reactivity in Patients Presenting With ST-Segment Elevation Myocardial Infarction Due to Coronary Stent Thrombosis Undergoing Primary Percutaneous Coronary Intervention Results From the European PREvention of Stent Thrombosis by an Interdisciplinary Global European Effort Registry. JACC - Cardiovascular Interventions. New York: Elsevier Science Inc., 2017, roč. 10, č. 24, s. 2548-2556. ISSN 1936-8798. Dostupné z: https://dx.doi.org/10.1016/j.jcin.2017.09.019.

@article{1649918,
   author = {Godschalk, T. C. and Byrne, R. A. and Adriaenssens, T. and Malik, N. and Feldman, L. J. and Guagliumi, G. and Alfonso, F. and Neumann, F. J. and Trenk, D. and Joner, M. and Schulz, C. and Steg, P. G. and Goodall, A. H. and Wojdyla, R. and Dudek, D. and Wykrzykowska, J. J. and Hlinomaz, Ota and Zaman, A. G. and Curzen, N. and Dens, J. and Sinnaeve, P. and Desmet, W. and Gershlick, A. H. and Kastrati, A. and Massberg, S. and ten Berg, J. M.},
   article_location = {New York},
   article_number = {24},
   doi = {http://dx.doi.org/10.1016/j.jcin.2017.09.019},
   keywords = {aspirin; platelet aggregation; platelet function tests; P2Y(12) receptor antagonists; stent thrombosis},
   language = {eng},
   issn = {1936-8798},
   journal = {JACC - Cardiovascular Interventions},
   title = {Observational Study of Platelet Reactivity in Patients Presenting With ST-Segment Elevation Myocardial Infarction Due to Coronary Stent Thrombosis Undergoing Primary Percutaneous Coronary Intervention Results From the European PREvention of Stent Thrombosis by an Interdisciplinary Global European Effort Registry},
   url = {https://www.sciencedirect.com/science/article/pii/S1936879817319854?via%3Dihub},
   volume = {10},
   year = {2017}
}

TY  - JOUR
ID  - 1649918
AU  - Godschalk, T. C. - Byrne, R. A. - Adriaenssens, T. - Malik, N. - Feldman, L. J. - Guagliumi, G. - Alfonso, F. - Neumann, F. J. - Trenk, D. - Joner, M. - Schulz, C. - Steg, P. G. - Goodall, A. H. - Wojdyla, R. - Dudek, D. - Wykrzykowska, J. J. - Hlinomaz, Ota - Zaman, A. G. - Curzen, N. - Dens, J. - Sinnaeve, P. - Desmet, W. - Gershlick, A. H. - Kastrati, A. - Massberg, S. - ten Berg, J. M.
PY  - 2017
TI  - Observational Study of Platelet Reactivity in Patients Presenting With ST-Segment Elevation Myocardial Infarction Due to Coronary Stent Thrombosis Undergoing Primary Percutaneous Coronary Intervention Results From the European PREvention of Stent Thrombosis by an Interdisciplinary Global European Effort Registry
JF  - JACC - Cardiovascular Interventions
VL  - 10
IS  - 24
SP  - 2548-2556
EP  - 2548-2556
PB  - Elsevier Science Inc.
SN  - 19368798
KW  - aspirin
KW  - platelet aggregation
KW  - platelet function tests
KW  - P2Y(12) receptor antagonists
KW  - stent thrombosis
UR  - https://www.sciencedirect.com/science/article/pii/S1936879817319854?via%3Dihub
L2  - https://www.sciencedirect.com/science/article/pii/S1936879817319854?via%3Dihub
N2  - OBJECTIVES High platelet reactivity (HPR) was studied in patients presenting with ST-segment elevation myocardial infarction (STEMI) due to stent thrombosis (ST) undergoing immediate percutaneous coronary intervention (PCI). BACKGROUND HPR on P2Y12 inhibitors (HPR-ADP) is frequently observed in stable patients who have experienced ST. The HPR rates in patients presenting with ST for immediate PCI are unknown. METHODS Consecutive patients presenting with definite ST were included in a multicenter ST registry. Platelet reactivity was measured before immediate PCI with the VerifyNow P2Y12 or Aspirin assay. RESULTS Platelet reactivity was measured in 129 ST patients presenting with STEMI undergoing immediate PCI. HPR-ADP was observed in 76% of the patients, and HPR on aspirin (HPR-AA) was observed in 13% of the patients. HPR rates were similar in patients who were on maintenance P2Y12 inhibitor or aspirin since stent placement versus those without these medications. In addition, HPR-ADP was similar in patients loaded with a P2Y12 inhibitor shortly before immediate PCI versus those who were not. In contrast, HPR-AA trended to be lower in patients loaded with aspirin as compared with those not loaded. CONCLUSIONS Approximately 3 out of 4 ST patients with STEMI undergoing immediate PCI had HPR-ADP, and 13% had HPR-AA. Whether patients were on maintenance antiplatelet therapy while developing ST or loaded with P2Y12 inhibitors shortly before undergoing immediate PCI had no influence on the HPR rates. This raises concerns that the majority of patients with ST have suboptimal platelet inhibition undergoing immediate PCI. (C) 2017 by the American College of Cardiology Foundation.
ER  -

GODSCHALK, T. C., R. A. BYRNE, T. ADRIAENSSENS, N. MALIK, L. J. FELDMAN, G. GUAGLIUMI, F. ALFONSO, F. J. NEUMANN, D. TRENK, M. JONER, C. SCHULZ, P. G. STEG, A. H. GOODALL, R. WOJDYLA, D. DUDEK, J. J. WYKRZYKOWSKA, Ota HLINOMAZ, A. G. ZAMAN, N. CURZEN, J. DENS, P. SINNAEVE, W. DESMET, A. H. GERSHLICK, A. KASTRATI, S. MASSBERG a J. M. TEN BERG. Observational Study of Platelet Reactivity in Patients Presenting With ST-Segment Elevation Myocardial Infarction Due to Coronary Stent Thrombosis Undergoing Primary Percutaneous Coronary Intervention Results From the European PREvention of Stent Thrombosis by an Interdisciplinary Global European Effort Registry. \textit{JACC - Cardiovascular Interventions}. New York: Elsevier Science Inc., 2017, roč.~10, č.~24, s.~2548-2556. ISSN~1936-8798. Dostupné z: https://dx.doi.org/10.1016/j.jcin.2017.09.019.

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