Circulating endothelial-derived apoptotic microparticles and
insulin resistance in non-diabetic patients with chronic heart
failure

J 2016

Circulating endothelial-derived apoptotic microparticles and insulin resistance in non-diabetic patients with chronic heart failure

BEREZIN, A. E., A. A. KREMZER, G. CAMMAROTA, A. ZULLI, D. PETROVIC et. al.

Základní údaje

Originální název

Circulating endothelial-derived apoptotic microparticles and insulin resistance in non-diabetic patients with chronic heart failure

Autoři

BEREZIN, A. E. (804 Ukrajina), A. A. KREMZER (804 Ukrajina), G. CAMMAROTA (380 Itálie), A. ZULLI (36 Austrálie), D. PETROVIC (705 Slovinsko), N. MARTELL-CLAROS (724 Španělsko), J. SABO (703 Slovensko) a Peter KRUŽLIAK (703 Slovensko, garant, domácí)

Vydání

Clinical Chemistry and Laboratory medicine, BERLIN, WALTER DE GRUYTER & CO, 2016, 1434-6621

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30218 General and internal medicine

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.432

Kód RIV

RIV/00216224:14110/16:00113812

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1515/cclm-2015-0605

UT WoS

000377548500029

Klíčová slova anglicky

apoptotic endothelial-derived microparticles; chronic heart failure; insulin resistance

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 27. 4. 2020 15:47, Mgr. Tereza Miškechová

Anotace

V originále

Background: The objective of this study was to assess the relationship between insulin resistance and apoptotic endothelial-derived microparticles (EMPs) in patients with chronic heart failure (CHF). Methods: The study involved 300 CHF patients (186 males) aged 48-62 years with angiographically proven coronary artery disease and/or previously defined myocardial infarction. Insulin resistance was assessed by the homeostasis model assessment for insulin resistance (HOMA-IR). EMPs phenotype was determined by flow cytofluorometry. Results: Depending on HOMA-IR cut-off point (over and < 2.77 mmol/L x mu U/mL) all patients were divided into two cohorts with (n=171) or without (n=129) IR, respectively. Circulating EMPs were higher in CHF patients with IR than in patients without IR. Interestingly, EMPs were directly related to NYHA functional class of CHF, HOMAIR, NT-pro-BNP, hs-CRP and BMI. There was a significant association between the level of EMPs and HbA(1c), gender (r=0.318, p < 0.001 for male), age and smoking. On univariate and multivariate regression analysis we found that the NYHA class of CHF, NT-pro-BNP, hs-CRP, and left ventricular ejection fraction (LVEF) appeared to be independent predictors of increased circulatory apoptotic EMPs. The addition of HOMA-IR to the standard model (NYHA class CHF) improved the relative IDI by 19.9% for increased EMPs. For category-free NRI, 10% of events and 24% of non-events were correctly reclassified by the addition of HOMA-IR to the standard model for increased circulating EMPs. Conclusions: IR may be a contributing factor increasing circulating levels of apoptotic EMPs in non-diabetic CHF patients.

Citovat

BEREZIN, A. E., A. A. KREMZER, G. CAMMAROTA, A. ZULLI, D. PETROVIC, N. MARTELL-CLAROS, J. SABO a Peter KRUŽLIAK. Circulating endothelial-derived apoptotic microparticles and insulin resistance in non-diabetic patients with chronic heart failure. Clinical Chemistry and Laboratory medicine. BERLIN: WALTER DE GRUYTER & CO, 2016, roč. 54, č. 7, s. 1259-1267. ISSN 1434-6621. Dostupné z: https://dx.doi.org/10.1515/cclm-2015-0605.

@article{1650057,
   author = {Berezin, A. E. and Kremzer, A. A. and Cammarota, G. and Zulli, A. and Petrovic, D. and MartellandClaros, N. and Sabo, J. and Kružliak, Peter},
   article_location = {BERLIN},
   article_number = {7},
   doi = {http://dx.doi.org/10.1515/cclm-2015-0605},
   keywords = {apoptotic endothelial-derived microparticles; chronic heart failure; insulin resistance},
   language = {eng},
   issn = {1434-6621},
   journal = {Clinical Chemistry and Laboratory medicine},
   title = {Circulating endothelial-derived apoptotic microparticles and insulin resistance in non-diabetic patients with chronic heart failure},
   url = {https://www.degruyter.com/view/journals/cclm/54/7/article-p1259.xml},
   volume = {54},
   year = {2016}
}

TY  - JOUR
ID  - 1650057
AU  - Berezin, A. E. - Kremzer, A. A. - Cammarota, G. - Zulli, A. - Petrovic, D. - Martell-Claros, N. - Sabo, J. - Kružliak, Peter
PY  - 2016
TI  - Circulating endothelial-derived apoptotic microparticles and insulin resistance in non-diabetic patients with chronic heart failure
JF  - Clinical Chemistry and Laboratory medicine
VL  - 54
IS  - 7
SP  - 1259-1267
EP  - 1259-1267
PB  - WALTER DE GRUYTER & CO
SN  - 14346621
KW  - apoptotic endothelial-derived microparticles
KW  - chronic heart failure
KW  - insulin resistance
UR  - https://www.degruyter.com/view/journals/cclm/54/7/article-p1259.xml
L2  - https://www.degruyter.com/view/journals/cclm/54/7/article-p1259.xml
N2  - Background: The objective of this study was to assess the relationship between insulin resistance and apoptotic endothelial-derived microparticles (EMPs) in patients with chronic heart failure (CHF). Methods: The study involved 300 CHF patients (186 males) aged 48-62 years with angiographically proven coronary artery disease and/or previously defined myocardial infarction. Insulin resistance was assessed by the homeostasis model assessment for insulin resistance (HOMA-IR). EMPs phenotype was determined by flow cytofluorometry. Results: Depending on HOMA-IR cut-off point (over and < 2.77 mmol/L x mu U/mL) all patients were divided into two cohorts with (n=171) or without (n=129) IR, respectively. Circulating EMPs were higher in CHF patients with IR than in patients without IR. Interestingly, EMPs were directly related to NYHA functional class of CHF, HOMAIR, NT-pro-BNP, hs-CRP and BMI. There was a significant association between the level of EMPs and HbA(1c), gender (r=0.318, p < 0.001 for male), age and smoking. On univariate and multivariate regression analysis we found that the NYHA class of CHF, NT-pro-BNP, hs-CRP, and left ventricular ejection fraction (LVEF) appeared to be independent predictors of increased circulatory apoptotic EMPs. The addition of HOMA-IR to the standard model (NYHA class CHF) improved the relative IDI by 19.9% for increased EMPs. For category-free NRI, 10% of events and 24% of non-events were correctly reclassified by the addition of HOMA-IR to the standard model for increased circulating EMPs. Conclusions: IR may be a contributing factor increasing circulating levels of apoptotic EMPs in non-diabetic CHF patients.
ER  -

BEREZIN, A. E., A. A. KREMZER, G. CAMMAROTA, A. ZULLI, D. PETROVIC, N. MARTELL-CLAROS, J. SABO a Peter KRUŽLIAK. Circulating endothelial-derived apoptotic microparticles and insulin resistance in non-diabetic patients with chronic heart failure. \textit{Clinical Chemistry and Laboratory medicine}. BERLIN: WALTER DE GRUYTER \&{}amp; CO, 2016, roč.~54, č.~7, s.~1259-1267. ISSN~1434-6621. Dostupné z: https://dx.doi.org/10.1515/cclm-2015-0605.

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