| NYSSEN, O. P., A. PEREZ-AISA, B. TEPES, L. RODRIGO-SAEZ, P. M. ROMERO, A. LUCENDO, M. CASTRO-FERNANDEZ, P. PHULL, J. BARRIO, L. BUJANDA, J. ORTUNO, M. AREIA, N. B. JURECIC, J. M. HUGUET, N. ALCAIDE, I. VOYNOVAN, J. M. B. BOTE, I. MODOLELL, J. P. LASALA, I. ARINO, L. JONAITIS, M. DOMINGUEZ-CAJAL, G. BUZAS, F. LERANG, M. PERONA, D. BORDIN, T. AXON, A. GASBARRINI, R. M. PINTO, Y. NIV, L. KUPCINSKAS, A. TONKIC, M. LEJA, T. ROKKAS, L. BOYANOVA, O. SHVETS, M. VENERITO, P. BYTZER, A. GOLDIS, I. SIMSEK, V. LAMY, K. PRZYTULSKI, Lumír KUNOVSKÝ, L. CAPELLE, T. MILOSAVLJEVIC, M. CALDAS, A. GARRE, F. MEGRAUD, C. O'MORAIN a J. P. GISBERT. Helicobacter pylori first-line and rescue treatments in patients allergic to penicillin: Experience from the European Registry on H pylori management (Hp-EuReg). Helicobacter. HOBOKEN: WILEY, 2020, roč. 25, č. 3, s. 1-11. ISSN 1083-4389. Dostupné z: https://dx.doi.org/10.1111/hel.12686. |
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@article{1655056,
author = {Nyssen, O. P. and PerezandAisa, A. and Tepes, B. and RodrigoandSaez, L. and Romero, P. M. and Lucendo, A. and CastroandFernandez, M. and Phull, P. and Barrio, J. and Bujanda, L. and Ortuno, J. and Areia, M. and Jurecic, N. B. and Huguet, J. M. and Alcaide, N. and Voynovan, I. and Bote, J. M. B. and Modolell, I. and Lasala, J. P. and Arino, I. and Jonaitis, L. and DominguezandCajal, M. and Buzas, G. and Lerang, F. and Perona, M. and Bordin, D. and Axon, T. and Gasbarrini, A. and Pinto, R. M. and Niv, Y. and Kupcinskas, L. and Tonkic, A. and Leja, M. and Rokkas, T. and Boyanova, L. and Shvets, O. and Venerito, M. and Bytzer, P. and Goldis, A. and Simsek, I. and Lamy, V. and Przytulski, K. and Kunovský, Lumír and Capelle, L. and Milosavljevic, T. and Caldas, M. and Garre, A. and Megraud, F. and O'Morain, C. and Gisbert, J. P.},
article_location = {HOBOKEN},
article_number = {3},
doi = {http://dx.doi.org/10.1111/hel.12686},
keywords = {allergic; allergy; bismuth; clarithromycin; Helicobacter pylori; levofloxacin; penicillin},
language = {eng},
issn = {1083-4389},
journal = {Helicobacter},
title = {Helicobacter pylori first-line and rescue treatments in patients allergic to penicillin: Experience from the European Registry on H pylori management (Hp-EuReg)},
url = {https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/hel.12686},
volume = {25},
year = {2020}
}
TY - JOUR
ID - 1655056
AU - Nyssen, O. P. - Perez-Aisa, A. - Tepes, B. - Rodrigo-Saez, L. - Romero, P. M. - Lucendo, A. - Castro-Fernandez, M. - Phull, P. - Barrio, J. - Bujanda, L. - Ortuno, J. - Areia, M. - Jurecic, N. B. - Huguet, J. M. - Alcaide, N. - Voynovan, I. - Bote, J. M. B. - Modolell, I. - Lasala, J. P. - Arino, I. - Jonaitis, L. - Dominguez-Cajal, M. - Buzas, G. - Lerang, F. - Perona, M. - Bordin, D. - Axon, T. - Gasbarrini, A. - Pinto, R. M. - Niv, Y. - Kupcinskas, L. - Tonkic, A. - Leja, M. - Rokkas, T. - Boyanova, L. - Shvets, O. - Venerito, M. - Bytzer, P. - Goldis, A. - Simsek, I. - Lamy, V. - Przytulski, K. - Kunovský, Lumír - Capelle, L. - Milosavljevic, T. - Caldas, M. - Garre, A. - Megraud, F. - O'Morain, C. - Gisbert, J. P.
PY - 2020
TI - Helicobacter pylori first-line and rescue treatments in patients allergic to penicillin: Experience from the European Registry on H pylori management (Hp-EuReg)
JF - Helicobacter
VL - 25
IS - 3
SP - 1-11
EP - 1-11
PB - WILEY
SN - 10834389
KW - allergic
KW - allergy
KW - bismuth
KW - clarithromycin
KW - Helicobacter pylori
KW - levofloxacin
KW - penicillin
UR - https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/hel.12686
L2 - https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/hel.12686
N2 - Background Experience in Helicobacter pylori eradication treatment of patients allergic to penicillin is very scarce. A triple combination with a PPI, clarithromycin (C), and metronidazole (M) is often prescribed as the first option, although more recently the use of a quadruple therapy with PPI, bismuth (B), tetracycline (T), and M has been recommended. Aim To evaluate the efficacy and safety of first-line and rescue treatments in patients allergic to penicillin in the "European Registry of H pylori management" (Hp-EuReg). Methods A systematic prospective registry of the clinical practice of European gastroenterologists (27 countries, 300 investigators) on the management of H pylori infection. An e-CRF was created on AEG-REDCap. Patients with penicillin allergy were analyzed until June 2019. Results One-thousand eighty-four patients allergic to penicillin were analyzed. The most frequently prescribed first-line treatments were as follows: PPI + C + M (n = 285) and PPI + B + T + M (classic or Pylera(R); n = 250). In first line, the efficacy of PPI + C + M was 69%, while PPI + B + T + M reached 91% (P < .001). In second line, after the failure of PPI + C + M, two rescue options showed similar efficacy: PPI + B + T + M (78%) and PPI + C + levofloxacin (L) (71%) (P > .05). In third line, after the failure of PPI + C + M and PPI + C + L, PPI + B + T + M was successful in 75% of cases. Conclusion In patients allergic to penicillin, a triple combination with PPI + C + M should not be generally recommended as a first-line treatment, while a quadruple regimen with PPI + B + T + M seems to be a better option. As a rescue treatment, this quadruple regimen (if not previously prescribed) or a triple regimen with PPI + C + L could be used but achieved suboptimal (<80%) results.
ER -
NYSSEN, O. P., A. PEREZ-AISA, B. TEPES, L. RODRIGO-SAEZ, P. M. ROMERO, A. LUCENDO, M. CASTRO-FERNANDEZ, P. PHULL, J. BARRIO, L. BUJANDA, J. ORTUNO, M. AREIA, N. B. JURECIC, J. M. HUGUET, N. ALCAIDE, I. VOYNOVAN, J. M. B. BOTE, I. MODOLELL, J. P. LASALA, I. ARINO, L. JONAITIS, M. DOMINGUEZ-CAJAL, G. BUZAS, F. LERANG, M. PERONA, D. BORDIN, T. AXON, A. GASBARRINI, R. M. PINTO, Y. NIV, L. KUPCINSKAS, A. TONKIC, M. LEJA, T. ROKKAS, L. BOYANOVA, O. SHVETS, M. VENERITO, P. BYTZER, A. GOLDIS, I. SIMSEK, V. LAMY, K. PRZYTULSKI, Lumír KUNOVSKÝ, L. CAPELLE, T. MILOSAVLJEVIC, M. CALDAS, A. GARRE, F. MEGRAUD, C. O'MORAIN a J. P. GISBERT. Helicobacter pylori first-line and rescue treatments in patients allergic to penicillin: Experience from the European Registry on H pylori management (Hp-EuReg). \textit{Helicobacter}. HOBOKEN: WILEY, 2020, roč.~25, č.~3, s.~1-11. ISSN~1083-4389. Dostupné z: https://dx.doi.org/10.1111/hel.12686.
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