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@inproceedings{1662864,
author = {Botka, Tibor and Fišarová, Lenka and Bárdy, Pavol and Benešík, Martin and Mašlaňová, Ivana and Pantůček, Roman and Doškař, Jiří},
address = {Brno},
booktitle = {Tomáškovy dny 2020 - XXIX. konference mladých mikrobiologů},
editor = {Mgr. Lukáš Vacek},
howpublished = {elektronická verze "online"},
location = {Brno},
isbn = {978-80-210-9611-0},
pages = {29},
publisher = {Masarykova univerzita},
title = {Genomic properties of new transducing phages and mobile genetic elements of Staphylococcus epidermidis},
url = {https://www.med.muni.cz/tomdny/program},
year = {2020}
}
TY - JOUR
ID - 1662864
AU - Botka, Tibor - Fišarová, Lenka - Bárdy, Pavol - Benešík, Martin - Mašlaňová, Ivana - Pantůček, Roman - Doškař, Jiří
PY - 2020
TI - Genomic properties of new transducing phages and mobile genetic elements of Staphylococcus epidermidis
PB - Masarykova univerzita
CY - Brno
SN - 9788021096110
UR - https://www.med.muni.cz/tomdny/program
N2 - Staphylococcus epidermidis mobile genetic elements (MGE), including temperate phages and phage-inducible chromosomal islands (PICI), are still not well described. However, through the horizontal gene transfer, they determine properties such as antibiotic resistance and/or virulence to their hosts. Our work characterizes new bacteriophages able to transduce S. epidermidis PICIs and plasmids. Genomes of four temperate siphoviruses and their propagation strains were obtained using Oxford Nanopore and Illumina sequencing technology. Phage genomes were described and compared in detail. Differences found in otherwise conservative modules of morphogenesis and DNA packaging possibly played a role in frequency of PICI and plasmid transduction. Different PICIs localized in host genomes contain known and/or putative resistance genes as well as genes for helper phage virion assembly alteration. In portion of helper phage particles, noticeable changes in capsid morphology were observed. Our findings confirm the important role of transducing phages in the evolution of S. epidermidis strains and outline host mechanisms of phage infection disruption. This work was supported by Grant of Czech Science Foundation (GA18-13064S) and Development Fund of Masaryk University MUNI/FR/1181/2018.
ER -
BOTKA, Tibor, Lenka FIŠAROVÁ, Pavol BÁRDY, Martin BENEŠÍK, Ivana MAŠLAŇOVÁ, Roman PANTŮČEK and Jiří DOŠKAŘ. Genomic properties of new transducing phages and mobile genetic elements of Staphylococcus epidermidis. Online. In Mgr. Lukáš Vacek. \textit{Tomáškovy dny 2020 - XXIX. konference mladých mikrobiologů}. Brno: Masarykova univerzita, 2020, p.~29. ISBN~978-80-210-9611-0.
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