Spontaneous adenocarcinoma of the gas gland in Nothobranchius fishes

DYKOVÁ, Iva, Radim BLAŽEK, Kamila SOUČKOVÁ, Martin REICHARD and Ondřej SLABÝ. Spontaneous adenocarcinoma of the gas gland in Nothobranchius fishes. Diseases of Aquatic Organisms. Oldendorf (Luhe): Inter-Research, 2020, vol. 137, No 3, p. 205-210. ISSN 0177-5103. Available from: https://dx.doi.org/10.3354/dao03437.

Basic information

• Original name: Spontaneous adenocarcinoma of the gas gland in Nothobranchius fishes
• Authors: DYKOVÁ, Iva (203 Czech Republic, guarantor, belonging to the institution), Radim BLAŽEK, Kamila SOUČKOVÁ (203 Czech Republic, belonging to the institution), Martin REICHARD and Ondřej SLABÝ (203 Czech Republic, belonging to the institution).
• Edition: Diseases of Aquatic Organisms, Oldendorf (Luhe), Inter-Research, 2020, 0177-5103.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 10700 1.7 Other natural sciences
• Country of publisher: Germany
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 1.802
• RIV identification code: RIV/00216224:14740/20:00114193
• Organization unit: Central European Institute of Technology
• Doi: http://dx.doi.org/10.3354/dao03437
• UT WoS: 000521736600005
• Keywords in English: Nothobranchius fishes; Spontaneous neoplasia; Gas gland adenocarcinoma
• Tags: rivok
• Tags: International impact, Reviewed

Abstract

Nothobranchius fishes (Cyprinodontiformes), known for their genetically encoded extremely compressed lifespan, are considered an excellent vertebrate model for the research of aging. Unlike the rapid accumulation of data concerning their biology, ecology and genome, knowledge of their age-related diseases, including tumours, is still very limited. This Note reports spontaneous neoplastic lesions in the swim bladder gas glands of Nothobranchius furzeri, N. kadleci and N. orthonotus. Based on light and transmission electron microscopy, the neoplastic proliferation of gas gland cells was classified as adenocarcinoma. There was a concurrent proliferation of haemopoietic cells in the kidney interstitium in all individuals diagnosed with this type of primary neoplasia.

Links

• GA19-20873S, research and development project: Name: Klíčové mutace v nádorovém genomu Nothobranchius furzeri: od nádorové biologie k návrhu experimentálního modelu sporadické kancerogeneze

Investor: Czech Science Foundation, Driver mutations in cancer genome of Nothobranchius furzeri: from tumor biology to concept of experimental model of spontaneous carcinogenesis