| POPOVICH, Kseniya, Karel KLEPÁRNÍK, Vojtěch LEDVINA, Barbora NEUŽILOVÁ, Jindřich FLEIŠMANN, Michaela ŠKODOVÁ, Libor KOBERA, Eva MIHÓKOVÁ, Viliam MÚČKA a Václav ČUBA. Luminescent Nanocomposites for Biomedical Applications. IEEE Transactions on Nuclear Science. Institute of Electrical and Electronics Engineers, 2020, roč. 67, č. 6, s. 962-968. ISSN 0018-9499. Dostupné z: https://dx.doi.org/10.1109/TNS.2020.2974316. |
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@article{1668305,
author = {Popovich, Kseniya and Klepárník, Karel and Ledvina, Vojtěch and Neužilová, Barbora and Fleišmann, Jindřich and Škodová, Michaela and Kobera, Libor and Mihóková, Eva and Múčka, Viliam and Čuba, Václav},
article_number = {6},
doi = {http://dx.doi.org/10.1109/TNS.2020.2974316},
keywords = {Nanoparticles; Nanocomposites; Temperature measurement; Drugs; Surface treatment; Silicon compounds; Scanning electron microscopy; Bioimaging; cathodoluminescence (CL); LuAG; nanocomposite; nanoparticles},
language = {eng},
issn = {0018-9499},
journal = {IEEE Transactions on Nuclear Science},
title = {Luminescent Nanocomposites for Biomedical Applications},
url = {https://ieeexplore.ieee.org/document/9000703},
volume = {67},
year = {2020}
}
TY - JOUR
ID - 1668305
AU - Popovich, Kseniya - Klepárník, Karel - Ledvina, Vojtěch - Neužilová, Barbora - Fleišmann, Jindřich - Škodová, Michaela - Kobera, Libor - Mihóková, Eva - Múčka, Viliam - Čuba, Václav
PY - 2020
TI - Luminescent Nanocomposites for Biomedical Applications
JF - IEEE Transactions on Nuclear Science
VL - 67
IS - 6
SP - 962-968
EP - 962-968
PB - Institute of Electrical and Electronics Engineers
SN - 00189499
KW - Nanoparticles
KW - Nanocomposites
KW - Temperature measurement
KW - Drugs
KW - Surface treatment
KW - Silicon compounds
KW - Scanning electron microscopy
KW - Bioimaging
KW - cathodoluminescence (CL)
KW - LuAG
KW - nanocomposite
KW - nanoparticles
UR - https://ieeexplore.ieee.org/document/9000703
L2 - https://ieeexplore.ieee.org/document/9000703
N2 - In this work, we pursue a concept of the multimodal drug preparation based on LuAG:Ce3+ nanoparticles. The functionality studied in this article is focused on the bioimaging of living cells via cathodoluminescence (CL) of scintillating nanoparticles attached to the cell surface. LuAG:Ce3+ scintillating nanoparticles were used as a core; amorphous or mesoporous SiO2 was used as a shell encapsulating the core to increase the surface reactivity; anti-Fas ligand (FasL) antibody was then attached to the outer shell in order to specifically bond the nanocomposite to the cell receptors; finally, polyethylene glycol molecules were attached to increase the biocompatibility of the nanocomposites. CL bioimaging was tested on yeasts Saccharomyces cerevisiae and leukocytes. It was found that the nanocomposites are able to attach to the cells via sorption or bonding to the receptors. The prepared nanocomposite shows stable luminescence under 10-keV electron irradiation, thus making a prospective candidate for this application and future multimodal drug design.
ER -
POPOVICH, Kseniya, Karel KLEPÁRNÍK, Vojtěch LEDVINA, Barbora NEUŽILOVÁ, Jindřich FLEIŠMANN, Michaela ŠKODOVÁ, Libor KOBERA, Eva MIHÓKOVÁ, Viliam MÚČKA a Václav ČUBA. Luminescent Nanocomposites for Biomedical Applications. \textit{IEEE Transactions on Nuclear Science}. Institute of Electrical and Electronics Engineers, 2020, roč.~67, č.~6, s.~962-968. ISSN~0018-9499. Dostupné z: https://dx.doi.org/10.1109/TNS.2020.2974316.
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