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@article{1668639,
author = {Jabandžiev, Petr and Bohošová, Júlia and Pinkasová, Tereza and Kunovský, Lumír and Slabý, Ondřej and Goel, Ajay},
article_number = {7},
doi = {http://dx.doi.org/10.1093/ibd/izaa009},
keywords = {pediatrics; inflammatory bowel disease; Crohn’s disease; ulcerative colitis; noncoding RNA; microRNA},
language = {eng},
issn = {1078-0998},
journal = {Inflammatory Bowel Diseases},
title = {The Emerging Role of Noncoding RNAs in Pediatric Inflammatory Bowel Disease},
url = {https://academic.oup.com/ibdjournal/article/26/7/985/5721205},
volume = {26},
year = {2020}
}
TY - JOUR
ID - 1668639
AU - Jabandžiev, Petr - Bohošová, Júlia - Pinkasová, Tereza - Kunovský, Lumír - Slabý, Ondřej - Goel, Ajay
PY - 2020
TI - The Emerging Role of Noncoding RNAs in Pediatric Inflammatory Bowel Disease
JF - Inflammatory Bowel Diseases
VL - 26
IS - 7
SP - 985-993
EP - 985-993
PB - Oxford University Press
SN - 10780998
KW - pediatrics
KW - inflammatory bowel disease
KW - Crohn’s disease
KW - ulcerative colitis
KW - noncoding RNA
KW - microRNA
UR - https://academic.oup.com/ibdjournal/article/26/7/985/5721205
L2 - https://academic.oup.com/ibdjournal/article/26/7/985/5721205
N2 - Prevalence of inflammatory bowel disease (IBD), a chronic inflammatory disorder of the gut, has been on the rise in recent years—not only in the adult population but also especially in pediatric patients. Despite the absence of curative treatments, current therapeutic options are able to achieve long-term remission in a significant proportion of cases. To this end, however, there is a need for biomarkers enabling accurate diagnosis, prognosis, and prediction of response to therapies to facilitate a more individualized approach to pediatric IBD patients. In recent years, evidence has continued to evolve concerning noncoding RNAs (ncRNAs) and their roles as integral factors in key immune-related cellular pathways. Specific deregulation patterns of ncRNAs have been linked to pathogenesis of various diseases, including pediatric IBD. In this article, we provide an overview of current knowledge on ncRNAs, their altered expression profiles in pediatric IBD patients, and how these are emerging as potentially valuable clinical biomarkers as we enter an era of personalized medicine.
ER -
JABANDŽIEV, Petr, Júlia BOHOŠOVÁ, Tereza PINKASOVÁ, Lumír KUNOVSKÝ, Ondřej SLABÝ a Ajay GOEL. The Emerging Role of Noncoding RNAs in Pediatric Inflammatory Bowel Disease. \textit{Inflammatory Bowel Diseases}. Oxford University Press, 2020, roč.~26, č.~7, s.~985-993. ISSN~1078-0998. Dostupné z: https://dx.doi.org/10.1093/ibd/izaa009.
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