Composite Hemostatic Nonwoven Textiles Based on Hyaluronic
Acid, Cellulose, and Etamsylate

J 2020

Composite Hemostatic Nonwoven Textiles Based on Hyaluronic Acid, Cellulose, and Etamsylate

SUCHÝ, Pavel, Alice PAPRSKÁROVÁ, Marta CHALUPOVÁ, Lucie MARHOLDOVA, Kristina NESPOROVA et. al.

Základní údaje

Originální název

Composite Hemostatic Nonwoven Textiles Based on Hyaluronic Acid, Cellulose, and Etamsylate

Autoři

SUCHÝ, Pavel (203 Česká republika, domácí), Alice PAPRSKÁROVÁ (203 Česká republika, garant), Marta CHALUPOVÁ (203 Česká republika, domácí), Lucie MARHOLDOVA (203 Česká republika), Kristina NESPOROVA (203 Česká republika), Jarmila KLUSÁKOVÁ (203 Česká republika, domácí), Gabriela KUZMÍNOVÁ (203 Česká republika, domácí), Michal HENDRYCH (203 Česká republika, domácí) a Vladimir VELEBNY (203 Česká republika)

Vydání

Materials, ST ALBAN-ANLAGE, MDPI, 2020, 1996-1944

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.623

Kód RIV

RIV/00216224:14160/20:00115895

Organizační jednotka

Farmaceutická fakulta

DOI

http://dx.doi.org/10.3390/ma13071627

UT WoS

000529875600145

Klíčová slova anglicky

hemostasis; hyaluronic acid; cellulose; etamsylate; nonwoven textile

Štítky

14110112, 14110515, podil, rivok, ÚFTo

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 26. 2. 2021 12:48, Mgr. Hana Hurtová

Anotace

V originále

The achievement of rapid hemostasis represents a long-term trend in hemostatic research. Specifically, composite materials are now the focus of attention, based on the given issues and required properties. In urology, different materials are used to achieve fast and effective hemostasis. Additionally, it is desirable to exert a positive influence on local tissue reaction. In this study, three nonwoven textiles prepared by a wet spinning method and based on a combination of hyaluronic acid with either oxidized cellulose or carboxymethyl cellulose, along with the addition of etamsylate, were introduced and assessed in vivo using the rat partial nephrectomy model. A significantly shorter time to hemostasis in seconds (p < 0.05), was attributed to the effect of the carboxymethyl cellulose material. The addition of etamsylate did not noticeably contribute to further hemostasis, but its application strengthened the structure and therefore significantly improved the effect on local changes, while also facilitating any manipulation by the surgeons. Specifically, the hyaluronic acid supported the tissue healing and regeneration, and ensured the favorable results of the histological analysis. Moreover, the prepared textiles proved their bioresorbability after a three-day period. In brief, the fabrics yielded favorable hemostatic activity, bioresorbability, non-irritability, and had a beneficial effect on the tissue repair.

Citovat

SUCHÝ, Pavel, Alice PAPRSKÁROVÁ, Marta CHALUPOVÁ, Lucie MARHOLDOVA, Kristina NESPOROVA, Jarmila KLUSÁKOVÁ, Gabriela KUZMÍNOVÁ, Michal HENDRYCH a Vladimir VELEBNY. Composite Hemostatic Nonwoven Textiles Based on Hyaluronic Acid, Cellulose, and Etamsylate. Materials. ST ALBAN-ANLAGE: MDPI, 2020, roč. 13, č. 7, s. 1-14. ISSN 1996-1944. Dostupné z: https://dx.doi.org/10.3390/ma13071627.

@article{1668656,
   author = {Suchý, Pavel and Paprskárová, Alice and Chalupová, Marta and Marholdova, Lucie and Nesporova, Kristina and Klusáková, Jarmila and Kuzmínová, Gabriela and Hendrych, Michal and Velebny, Vladimir},
   article_location = {ST ALBAN-ANLAGE},
   article_number = {7},
   doi = {http://dx.doi.org/10.3390/ma13071627},
   keywords = {hemostasis; hyaluronic acid; cellulose; etamsylate; nonwoven textile},
   language = {eng},
   issn = {1996-1944},
   journal = {Materials},
   title = {Composite Hemostatic Nonwoven Textiles Based on Hyaluronic Acid, Cellulose, and Etamsylate},
   url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178357/},
   volume = {13},
   year = {2020}
}

TY  - JOUR
ID  - 1668656
AU  - Suchý, Pavel - Paprskárová, Alice - Chalupová, Marta - Marholdova, Lucie - Nesporova, Kristina - Klusáková, Jarmila - Kuzmínová, Gabriela - Hendrych, Michal - Velebny, Vladimir
PY  - 2020
TI  - Composite Hemostatic Nonwoven Textiles Based on Hyaluronic Acid, Cellulose, and Etamsylate
JF  - Materials
VL  - 13
IS  - 7
SP  - 1-14
EP  - 1-14
PB  - MDPI
SN  - 19961944
KW  - hemostasis
KW  - hyaluronic acid
KW  - cellulose
KW  - etamsylate
KW  - nonwoven textile
UR  - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178357/
L2  - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178357/
N2  - The achievement of rapid hemostasis represents a long-term trend in hemostatic research. Specifically, composite materials are now the focus of attention, based on the given issues and required properties. In urology, different materials are used to achieve fast and effective hemostasis. Additionally, it is desirable to exert a positive influence on local tissue reaction. In this study, three nonwoven textiles prepared by a wet spinning method and based on a combination of hyaluronic acid with either oxidized cellulose or carboxymethyl cellulose, along with the addition of etamsylate, were introduced and assessed in vivo using the rat partial nephrectomy model. A significantly shorter time to hemostasis in seconds (p < 0.05), was attributed to the effect of the carboxymethyl cellulose material. The addition of etamsylate did not noticeably contribute to further hemostasis, but its application strengthened the structure and therefore significantly improved the effect on local changes, while also facilitating any manipulation by the surgeons. Specifically, the hyaluronic acid supported the tissue healing and regeneration, and ensured the favorable results of the histological analysis. Moreover, the prepared textiles proved their bioresorbability after a three-day period. In brief, the fabrics yielded favorable hemostatic activity, bioresorbability, non-irritability, and had a beneficial effect on the tissue repair.
ER  -

SUCHÝ, Pavel, Alice PAPRSKÁROVÁ, Marta CHALUPOVÁ, Lucie MARHOLDOVA, Kristina NESPOROVA, Jarmila KLUSÁKOVÁ, Gabriela KUZMÍNOVÁ, Michal HENDRYCH a Vladimir VELEBNY. Composite Hemostatic Nonwoven Textiles Based on Hyaluronic Acid, Cellulose, and Etamsylate. \textit{Materials}. ST ALBAN-ANLAGE: MDPI, 2020, roč.~13, č.~7, s.~1-14. ISSN~1996-1944. Dostupné z: https://dx.doi.org/10.3390/ma13071627.

Podrobný výpis o publikaci