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@article{1668745,
author = {Štefančíková, Lenka and Moulis, Mojmír and Fabian, P. and Falkova, I. and Vasova, I. and Kren, L. and Macak, J. and Šmardová, Jana},
article_location = {Philadelphia},
article_number = {10},
doi = {http://dx.doi.org/10.1136/jcp.2008.063701},
keywords = {GENE; OVEREXPRESSION; CCND2},
language = {eng},
issn = {0002-9173},
journal = {American journal of clinical pathology : official publication the American Society of Clinical Pathologists.},
title = {Complex analysis of cyclin D1 expression in mantle cell lymphoma: two cyclin D1-negative cases detected},
url = {https://jcp.bmj.com/content/jclinpath/62/10/948.full.pdf},
volume = {62},
year = {2009}
}
TY - JOUR
ID - 1668745
AU - Štefančíková, Lenka - Moulis, Mojmír - Fabian, P. - Falkova, I. - Vasova, I. - Kren, L. - Macak, J. - Šmardová, Jana
PY - 2009
TI - Complex analysis of cyclin D1 expression in mantle cell lymphoma: two cyclin D1-negative cases detected
JF - American journal of clinical pathology : official publication the American Society of Clinical Pathologists.
VL - 62
IS - 10
SP - 948-950
EP - 948-950
PB - J. B. Lippincott Company
SN - 00029173
KW - GENE
KW - OVEREXPRESSION
KW - CCND2
UR - https://jcp.bmj.com/content/jclinpath/62/10/948.full.pdf
N2 - Background and Aim: The cytogenetic and diagnostic hallmark of mantle cell lymphoma (MCL) is translocation t(11; 14)(q13; q32), resulting in overexpression of cyclin D1. Cyclin D1 expression was analysed in 32 cases of MCL. Methods: The t(11; 14) translocation was detected by fluorescence in situ hybridisation, level of cyclin D1 mRNA by competitive RT-PCR, and level of cyclin D1 and D2 proteins by immunohistochemistry and/or immunoblotting. Results: In 30 cases, the presence of translocation t(11; 14), a high level of cyclin D1 mRNA, and a high level of the cyclin D1 protein were confirmed. Two cyclin D1-negative cases overexpressing cyclin D2 were detected by immunoblotting. Conclusions: There are rare cyclin D1-negative cases of MCL overexpressing cyclin D2. Anti-cyclin D1 antibodies with low specificity can bind both cyclin D1 and cyclin D2, thus providing false cyclin D1-positive signals in immunohistochemical analysis.
ER -
ŠTEFANČÍKOVÁ, Lenka, Mojmír MOULIS, P. FABIAN, I. FALKOVA, I. VASOVA, L. KREN, J. MACAK a Jana ŠMARDOVÁ. Complex analysis of cyclin D1 expression in mantle cell lymphoma: two cyclin D1-negative cases detected. \textit{American journal of clinical pathology : official publication the American Society of Clinical Pathologists.}. Philadelphia: J. B. Lippincott Company, 2009, roč.~62, č.~10, s.~948-950. ISSN~0002-9173. Dostupné z: https://dx.doi.org/10.1136/jcp.2008.063701.
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