Caveolin-1 in oncogenic metabolic symbiosis

J 2020

Caveolin-1 in oncogenic metabolic symbiosis

RAUDENSKÁ, Martina, Jaromír GUMULEC, Jan BALVAN a Michal MASAŘÍK

Základní údaje

Originální název

Caveolin-1 in oncogenic metabolic symbiosis

Autoři

RAUDENSKÁ, Martina (203 Česká republika, domácí), Jaromír GUMULEC (203 Česká republika, domácí), Jan BALVAN (203 Česká republika, domácí) a Michal MASAŘÍK (203 Česká republika, garant, domácí)

Vydání

International journal of cancer, HOBOKEN, International Union Against Cancer, 2020, 0020-7136

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30204 Oncology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 7.396

Kód RIV

RIV/00216224:14110/20:00114233

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1002/ijc.32987

UT WoS

000527026700001

Klíčová slova anglicky

Caveolin-1; metabolic symbiosis; tumor microenvironment; cancer; metabolism; glycolysis; cancer-associated fibroblast

Štítky

14110515, 14110518, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 29. 10. 2020 13:07, Mgr. Tereza Miškechová

Anotace

V originále

Metabolic phenotypes of cancer cells are heterogeneous and flexible as a tumor mass is a hurriedly evolving system capable of constant adaptation to oxygen and nutrient availability. The exact type of cancer metabolism arises from the combined effects of factors intrinsic to the cancer cells and factors proposed by the tumor microenvironment. As a result, a condition termed oncogenic metabolic symbiosis in which components of the tumor microenvironment (TME) promote tumor growth often occurs. Understanding how oncogenic metabolic symbiosis emerges and evolves is crucial for perceiving tumorigenesis. The process by which tumor cells reprogram their TME involves many mechanisms, including changes in intercellular communication, alterations in metabolic phenotypes of TME cells, and rearrangement of the extracellular matrix. It is possible that one molecule with a pleiotropic effect such as Caveolin-1 may affect many of these pathways. Here, we discuss the significance of Caveolin-1 in establishing metabolic symbiosis in TME.

Návaznosti

GA18-03978S, projekt VaV

Název: Efekt buněčné tuhosti a mikroprostředí jako prediktor odpovědi na léčbu karcinomů hlavy a krku

Investor: Grantová agentura ČR, Efekt buněčné tuhosti a mikroprostředí jako prediktor odpovědi na léčbu karcinomů hlavy a krku

NV18-08-00229, projekt VaV

Název: Interakce buněk nádorového mikroprostředí jako nový nástroj predikce účinnosti terapie nádorů hlavy a krku

Investor: Ministerstvo zdravotnictví ČR, Cell interactions in tumour microenvironment as a new tool for therapy response prediction in head and neck cancer

Citovat

RAUDENSKÁ, Martina, Jaromír GUMULEC, Jan BALVAN a Michal MASAŘÍK. Caveolin-1 in oncogenic metabolic symbiosis. International journal of cancer. HOBOKEN: International Union Against Cancer, 2020, roč. 147, č. 7, s. 1793-1807. ISSN 0020-7136. Dostupné z: https://dx.doi.org/10.1002/ijc.32987.

@article{1670416,
   author = {Raudenská, Martina and Gumulec, Jaromír and Balvan, Jan and Masařík, Michal},
   article_location = {HOBOKEN},
   article_number = {7},
   doi = {http://dx.doi.org/10.1002/ijc.32987},
   keywords = {Caveolin-1; metabolic symbiosis; tumor microenvironment; cancer; metabolism; glycolysis; cancer-associated fibroblast},
   language = {eng},
   issn = {0020-7136},
   journal = {International journal of cancer},
   title = {Caveolin-1 in oncogenic metabolic symbiosis},
   url = {https://onlinelibrary.wiley.com/doi/full/10.1002/ijc.32987},
   volume = {147},
   year = {2020}
}

TY  - JOUR
ID  - 1670416
AU  - Raudenská, Martina - Gumulec, Jaromír - Balvan, Jan - Masařík, Michal
PY  - 2020
TI  - Caveolin-1 in oncogenic metabolic symbiosis
JF  - International journal of cancer
VL  - 147
IS  - 7
SP  - 1793-1807
EP  - 1793-1807
PB  - International Union Against Cancer
SN  - 00207136
KW  - Caveolin-1
KW  - metabolic symbiosis
KW  - tumor microenvironment
KW  - cancer
KW  - metabolism
KW  - glycolysis
KW  - cancer-associated fibroblast
UR  - https://onlinelibrary.wiley.com/doi/full/10.1002/ijc.32987
L2  - https://onlinelibrary.wiley.com/doi/full/10.1002/ijc.32987
N2  - Metabolic phenotypes of cancer cells are heterogeneous and flexible as a tumor mass is a hurriedly evolving system capable of constant adaptation to oxygen and nutrient availability. The exact type of cancer metabolism arises from the combined effects of factors intrinsic to the cancer cells and factors proposed by the tumor microenvironment. As a result, a condition termed oncogenic metabolic symbiosis in which components of the tumor microenvironment (TME) promote tumor growth often occurs. Understanding how oncogenic metabolic symbiosis emerges and evolves is crucial for perceiving tumorigenesis. The process by which tumor cells reprogram their TME involves many mechanisms, including changes in intercellular communication, alterations in metabolic phenotypes of TME cells, and rearrangement of the extracellular matrix. It is possible that one molecule with a pleiotropic effect such as Caveolin-1 may affect many of these pathways. Here, we discuss the significance of Caveolin-1 in establishing metabolic symbiosis in TME.
ER  -

RAUDENSKÁ, Martina, Jaromír GUMULEC, Jan BALVAN a Michal MASAŘÍK. Caveolin-1 in oncogenic metabolic symbiosis. \textit{International journal of cancer}. HOBOKEN: International Union Against Cancer, 2020, roč.~147, č.~7, s.~1793-1807. ISSN~0020-7136. Dostupné z: https://dx.doi.org/10.1002/ijc.32987.

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