| TRAN, T., M. STERCLOVA, N. MOGULKOC, K. LEWANDOWSKA, V. MULLER, M. HAJKOVA, M. R. KRAMER, D. JOVANOVIC, J. TEKAVEC-TRKANJEC, M. STUDNICKA, N. STOEVA, Karel HEJDUK, Ladislav DUŠEK, S. SUISSA, M. VASAKOVA, B. ZOLNOWSKA, V. BARTOS, M. PLACKOVA, R. SLIVKA, L. LACINA, M. DOUBKOVA, R. BITTENGLOVA, M. MARTUSEWIA-BOROS, M. ZURKOVA, I. JONNER, A. SZYMANOWSKA-NARIOCH, I. BINKOVA, M. SOBIECKA, V. LOSTAKOVA, M. TRZASKA-SOBCZAK, R. TYL, P. SLIWINSKI, M. ZSIRAY, P. LISA, A. BOHACS, S. MAJEWSKI, H. SULDOVA, B. MATULA, L. SISKOVA, J. PLUTINSKY, A. JAKIC, S. TOTH, Z. BALIKO, M. BUCEKOVA, J. PSIKALOVA, T. STACHURA, F. PETRIK, J. ANTON, J. LNENICKA, M. R. MILENKOVIC, I. LAJKO, V. RIHAK, Z. SZALAI, P. JUREK, A. KANIA, S. LASSAN, T. PEJCIC, P. REITERER, L. BORUCKI, R. KRALOVA, P. MUSILOVA, T. SNIZEK, D. DOLEZAL, J. HOMOLKA, H. HORTVIKOVA, S. MLADINOV, P. PALUCH, R. HRDINA, M. SZILASI, V. VUCINIC-MIHAILOVIC, R. VYSEHRADSKY, R. MOKOSOVA, A. NOWICKA a T. R. PETKOVIC. The European MultiPartner IPF registry (EMPIRE): validating long-term prognostic factors in idiopathic pulmonary fibrosis. RESPIRATORY RESEARCH. LONDON: BMC, 2020, roč. 21, č. 1, s. 1-9. ISSN 1465-9921. Dostupné z: https://dx.doi.org/10.1186/s12931-019-1271-z. |
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@article{1670460,
author = {Tran, T. and Sterclova, M. and Mogulkoc, N. and Lewandowska, K. and Muller, V. and Hajkova, M. and Kramer, M. R. and Jovanovic, D. and TekavecandTrkanjec, J. and Studnicka, M. and Stoeva, N. and Hejduk, Karel and Dušek, Ladislav and Suissa, S. and Vasakova, M. and Zolnowska, B. and Bartos, V. and Plackova, M. and Slivka, R. and Lacina, L. and Doubkova, M. and Bittenglova, R. and MartusewiaandBoros, M. and Zurkova, M. and Jonner, I. and SzymanowskaandNarioch, A. and Binkova, I. and Sobiecka, M. and Lostakova, V. and TrzaskaandSobczak, M. and Tyl, R. and Sliwinski, P. and Zsiray, M. and Lisa, P. and Bohacs, A. and Majewski, S. and Suldova, H. and Matula, B. and Siskova, L. and Plutinsky, J. and Jakic, A. and Toth, S. and Baliko, Z. and Bucekova, M. and Psikalova, J. and Stachura, T. and Petrik, F. and Anton, J. and Lnenicka, J. and Milenkovic, M. R. and Lajko, I. and Rihak, V. and Szalai, Z. and Jurek, P. and Kania, A. and Lassan, S. and Pejcic, T. and Reiterer, P. and Borucki, L. and Kralova, R. and Musilova, P. and Snizek, T. and Dolezal, D. and Homolka, J. and Hortvikova, H. and Mladinov, S. and Paluch, P. and Hrdina, R. and Szilasi, M. and VucinicandMihailovic, V. and Vysehradsky, R. and Mokosova, R. and Nowicka, A. and Petkovic, T. R.},
article_location = {LONDON},
article_number = {1},
doi = {http://dx.doi.org/10.1186/s12931-019-1271-z},
keywords = {CLINICAL-COURSE; STAGING SYSTEM; GAP SCORE; SURVIVAL; HYPERTENSION; PIRFENIDONE; EFFICACY},
language = {eng},
issn = {1465-9921},
journal = {RESPIRATORY RESEARCH},
title = {The European MultiPartner IPF registry (EMPIRE): validating long-term prognostic factors in idiopathic pulmonary fibrosis},
url = {https://respiratory-research.biomedcentral.com/track/pdf/10.1186/s12931-019-1271-z},
volume = {21},
year = {2020}
}
TY - JOUR
ID - 1670460
AU - Tran, T. - Sterclova, M. - Mogulkoc, N. - Lewandowska, K. - Muller, V. - Hajkova, M. - Kramer, M. R. - Jovanovic, D. - Tekavec-Trkanjec, J. - Studnicka, M. - Stoeva, N. - Hejduk, Karel - Dušek, Ladislav - Suissa, S. - Vasakova, M. - Zolnowska, B. - Bartos, V. - Plackova, M. - Slivka, R. - Lacina, L. - Doubkova, M. - Bittenglova, R. - Martusewia-Boros, M. - Zurkova, M. - Jonner, I. - Szymanowska-Narioch, A. - Binkova, I. - Sobiecka, M. - Lostakova, V. - Trzaska-Sobczak, M. - Tyl, R. - Sliwinski, P. - Zsiray, M. - Lisa, P. - Bohacs, A. - Majewski, S. - Suldova, H. - Matula, B. - Siskova, L. - Plutinsky, J. - Jakic, A. - Toth, S. - Baliko, Z. - Bucekova, M. - Psikalova, J. - Stachura, T. - Petrik, F. - Anton, J. - Lnenicka, J. - Milenkovic, M. R. - Lajko, I. - Rihak, V. - Szalai, Z. - Jurek, P. - Kania, A. - Lassan, S. - Pejcic, T. - Reiterer, P. - Borucki, L. - Kralova, R. - Musilova, P. - Snizek, T. - Dolezal, D. - Homolka, J. - Hortvikova, H. - Mladinov, S. - Paluch, P. - Hrdina, R. - Szilasi, M. - Vucinic-Mihailovic, V. - Vysehradsky, R. - Mokosova, R. - Nowicka, A. - Petkovic, T. R.
PY - 2020
TI - The European MultiPartner IPF registry (EMPIRE): validating long-term prognostic factors in idiopathic pulmonary fibrosis
JF - RESPIRATORY RESEARCH
VL - 21
IS - 1
SP - 1-9
EP - 1-9
PB - BMC
SN - 14659921
KW - CLINICAL-COURSE
KW - STAGING SYSTEM
KW - GAP SCORE
KW - SURVIVAL
KW - HYPERTENSION
KW - PIRFENIDONE
KW - EFFICACY
UR - https://respiratory-research.biomedcentral.com/track/pdf/10.1186/s12931-019-1271-z
L2 - https://respiratory-research.biomedcentral.com/track/pdf/10.1186/s12931-019-1271-z
N2 - Background Several registries of idiopathic pulmonary fibrosis (IPF) have been established to better understand its natural history, though their size and duration of follow-up are limited. Here, we describe the large European MultiPartner IPF Registry (EMPIRE) and validate predictors of long-term survival in IPF. Methods The multinational prospective EMPIRE registry enrolled IPF patients from 48 sites in 10 Central and Eastern European countries since 2014. Survival from IPF diagnosis until death was estimated, accounting for left-truncation. The Cox proportional hazards regression model was used to estimate adjusted hazard ratios (HR) of death for prognostic factors, using restricted cubic splines to fit continuous factors. Results The cohort included 1620 patients (mean age at diagnosis 67.6 years, 71% male, 63% smoking history), including 75% enrolled within 6 months of diagnosis. Median survival was 4.5 years, with 45% surviving 5 years post-diagnosis. Compared with GAP stage I, mortality was higher with GAP stages II (HR 2.9; 95% CI: 2.3-3.7) and III (HR 4.0; 95% CI: 2.8-5.7) while, with redefined cut-offs, the corresponding HRs were 2.7 (95% CI: 1.8-4.0) and 5.8 (95% CI: 4.0-8.3) respectively. Mortality was higher with concurrent pulmonary hypertension (HR 2.0; 95% CI: 1.5-2.9) and lung cancer (HR 2.6; 95% CI: 1.3-4.9). Conclusions EMPIRE, one of the largest long-term registries of patients with IPF, provides a more accurate confirmation of prognostic factors and co-morbidities on longer term five-year mortality. It also suggests that some fine-tuning of the indices for mortality may provide a more accurate long-term prognostic profile for these patients.
ER -
TRAN, T., M. STERCLOVA, N. MOGULKOC, K. LEWANDOWSKA, V. MULLER, M. HAJKOVA, M. R. KRAMER, D. JOVANOVIC, J. TEKAVEC-TRKANJEC, M. STUDNICKA, N. STOEVA, Karel HEJDUK, Ladislav DUŠEK, S. SUISSA, M. VASAKOVA, B. ZOLNOWSKA, V. BARTOS, M. PLACKOVA, R. SLIVKA, L. LACINA, M. DOUBKOVA, R. BITTENGLOVA, M. MARTUSEWIA-BOROS, M. ZURKOVA, I. JONNER, A. SZYMANOWSKA-NARIOCH, I. BINKOVA, M. SOBIECKA, V. LOSTAKOVA, M. TRZASKA-SOBCZAK, R. TYL, P. SLIWINSKI, M. ZSIRAY, P. LISA, A. BOHACS, S. MAJEWSKI, H. SULDOVA, B. MATULA, L. SISKOVA, J. PLUTINSKY, A. JAKIC, S. TOTH, Z. BALIKO, M. BUCEKOVA, J. PSIKALOVA, T. STACHURA, F. PETRIK, J. ANTON, J. LNENICKA, M. R. MILENKOVIC, I. LAJKO, V. RIHAK, Z. SZALAI, P. JUREK, A. KANIA, S. LASSAN, T. PEJCIC, P. REITERER, L. BORUCKI, R. KRALOVA, P. MUSILOVA, T. SNIZEK, D. DOLEZAL, J. HOMOLKA, H. HORTVIKOVA, S. MLADINOV, P. PALUCH, R. HRDINA, M. SZILASI, V. VUCINIC-MIHAILOVIC, R. VYSEHRADSKY, R. MOKOSOVA, A. NOWICKA a T. R. PETKOVIC. The European MultiPartner IPF registry (EMPIRE): validating long-term prognostic factors in idiopathic pulmonary fibrosis. \textit{RESPIRATORY RESEARCH}. LONDON: BMC, 2020, roč.~21, č.~1, s.~1-9. ISSN~1465-9921. Dostupné z: https://dx.doi.org/10.1186/s12931-019-1271-z.
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