Lactobacilli-dominated cervical microbiota in women with
preterm prelabor rupture of membranes

J 2020

Lactobacilli-dominated cervical microbiota in women with preterm prelabor rupture of membranes

KACEROVSKY, Marian, Lenka PLISKOVA, Radka BOLEHOVSKA, Romana GERYCHOVÁ, Petr JANKŮ et. al.

Základní údaje

Originální název

Lactobacilli-dominated cervical microbiota in women with preterm prelabor rupture of membranes

Autoři

KACEROVSKY, Marian (203 Česká republika, garant), Lenka PLISKOVA (203 Česká republika), Radka BOLEHOVSKA (203 Česká republika), Romana GERYCHOVÁ (203 Česká republika, domácí), Petr JANKŮ (203 Česká republika, domácí), Petr MATLAK (203 Česká republika), Ondrej SIMETKA (203 Česká republika), Tomas FAIST (203 Česká republika), Jan MLS (203 Česká republika), Petr VESCICIK (203 Česká republika), Helena ZEMLICKOVA (203 Česká republika), Bo JACOBSSON (752 Švédsko) a Ivana MUSILOVA (203 Česká republika)

Vydání

Pediatric Research, New York, Nature Publishing Group, 2020, 0031-3998

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30209 Paediatrics

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.756

Kód RIV

RIV/00216224:14110/20:00116019

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1038/s41390-019-0692-1

UT WoS

000525281400027

Klíčová slova anglicky

INTRAAMNIOTIC INFLAMMATION; PREMATURE RUPTURE; AMNIOTIC CAVITY; INTERLEUKIN-6; INVASION; FLUID

Štítky

14110411, GPK, GPKpor, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 17. 7. 2020 07:44, Mgr. Tereza Miškechová

Anotace

V originále

Background To determine the association between microbial invasion of the amniotic cavity (MIAC) and the presence of Lactobacillus crispatus- or Lactobacillus iners-dominated cervical microbiota in pregnancies with preterm prelabor rupture of membrane. Next, to assess the relationship between the presence of L. crispatus- or L. iners-dominated cervical microbiota and short-term neonatal morbidity. Method A total of 311 women were included. Cervical samples were obtained using a Dacron polyester swab and amniotic fluid samples were obtained by transabdominal amniocentesis. Bacterial DNA, L. crispatus, and L. iners in the cervical samples were assessed by PCR. Cervical microbiota was assigned as L. crispatus- or L. iners-dominated when the relative abundance of L. crispatus or L. iners was >= 50% of the whole cervical microbiota, respectively. Results Women with MIAC showed a lower rate of L. crispatus-dominated cervical microbiota (21% vs. 39%; p = 0.003) than those without MIAC. Lactobacillus crispatus-dominated cervical microbiota was associated with a lower rate of early-onset sepsis (0% vs. 5%; p = 0.02). Conclusions The presence of L. crispatus-dominated cervical microbiota in women with preterm prelabor rupture of membrane was associated with a lower risk of intra-amniotic complications and subsequent development of early-onset sepsis of newborns.

Citovat

KACEROVSKY, Marian, Lenka PLISKOVA, Radka BOLEHOVSKA, Romana GERYCHOVÁ, Petr JANKŮ, Petr MATLAK, Ondrej SIMETKA, Tomas FAIST, Jan MLS, Petr VESCICIK, Helena ZEMLICKOVA, Bo JACOBSSON a Ivana MUSILOVA. Lactobacilli-dominated cervical microbiota in women with preterm prelabor rupture of membranes. Pediatric Research. New York: Nature Publishing Group, 2020, roč. 87, č. 5, s. 952-960. ISSN 0031-3998. Dostupné z: https://dx.doi.org/10.1038/s41390-019-0692-1.

@article{1670597,
   author = {Kacerovsky, Marian and Pliskova, Lenka and Bolehovska, Radka and Gerychová, Romana and Janků, Petr and Matlak, Petr and Simetka, Ondrej and Faist, Tomas and Mls, Jan and Vescicik, Petr and Zemlickova, Helena and Jacobsson, Bo and Musilova, Ivana},
   article_location = {New York},
   article_number = {5},
   doi = {http://dx.doi.org/10.1038/s41390-019-0692-1},
   keywords = {INTRAAMNIOTIC INFLAMMATION; PREMATURE RUPTURE; AMNIOTIC CAVITY; INTERLEUKIN-6; INVASION; FLUID},
   language = {eng},
   issn = {0031-3998},
   journal = {Pediatric Research},
   title = {Lactobacilli-dominated cervical microbiota in women with preterm prelabor rupture of membranes},
   url = {https://www.nature.com/articles/s41390-019-0692-1},
   volume = {87},
   year = {2020}
}

TY  - JOUR
ID  - 1670597
AU  - Kacerovsky, Marian - Pliskova, Lenka - Bolehovska, Radka - Gerychová, Romana - Janků, Petr - Matlak, Petr - Simetka, Ondrej - Faist, Tomas - Mls, Jan - Vescicik, Petr - Zemlickova, Helena - Jacobsson, Bo - Musilova, Ivana
PY  - 2020
TI  - Lactobacilli-dominated cervical microbiota in women with preterm prelabor rupture of membranes
JF  - Pediatric Research
VL  - 87
IS  - 5
SP  - 952-960
EP  - 952-960
PB  - Nature Publishing Group
SN  - 00313998
KW  - INTRAAMNIOTIC INFLAMMATION
KW  - PREMATURE RUPTURE
KW  - AMNIOTIC CAVITY
KW  - INTERLEUKIN-6
KW  - INVASION
KW  - FLUID
UR  - https://www.nature.com/articles/s41390-019-0692-1
L2  - https://www.nature.com/articles/s41390-019-0692-1
N2  - Background To determine the association between microbial invasion of the amniotic cavity (MIAC) and the presence of Lactobacillus crispatus- or Lactobacillus iners-dominated cervical microbiota in pregnancies with preterm prelabor rupture of membrane. Next, to assess the relationship between the presence of L. crispatus- or L. iners-dominated cervical microbiota and short-term neonatal morbidity. Method A total of 311 women were included. Cervical samples were obtained using a Dacron polyester swab and amniotic fluid samples were obtained by transabdominal amniocentesis. Bacterial DNA, L. crispatus, and L. iners in the cervical samples were assessed by PCR. Cervical microbiota was assigned as L. crispatus- or L. iners-dominated when the relative abundance of L. crispatus or L. iners was >= 50% of the whole cervical microbiota, respectively. Results Women with MIAC showed a lower rate of L. crispatus-dominated cervical microbiota (21% vs. 39%; p = 0.003) than those without MIAC. Lactobacillus crispatus-dominated cervical microbiota was associated with a lower rate of early-onset sepsis (0% vs. 5%; p = 0.02). Conclusions The presence of L. crispatus-dominated cervical microbiota in women with preterm prelabor rupture of membrane was associated with a lower risk of intra-amniotic complications and subsequent development of early-onset sepsis of newborns.
ER  -

KACEROVSKY, Marian, Lenka PLISKOVA, Radka BOLEHOVSKA, Romana GERYCHOVÁ, Petr JANKŮ, Petr MATLAK, Ondrej SIMETKA, Tomas FAIST, Jan MLS, Petr VESCICIK, Helena ZEMLICKOVA, Bo JACOBSSON a Ivana MUSILOVA. Lactobacilli-dominated cervical microbiota in women with preterm prelabor rupture of membranes. \textit{Pediatric Research}. New York: Nature Publishing Group, 2020, roč.~87, č.~5, s.~952-960. ISSN~0031-3998. Dostupné z: https://dx.doi.org/10.1038/s41390-019-0692-1.

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