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@article{1671141,
author = {Šrámková, Petra and Zahoranová, Anna and Kelar, Jakub and Kelar Tučeková, Zlata and Stupavská, Monika and Krumpolec, Richard and Jurmanová, Jana and Kováčik, Dušan and Černák, Mirko},
article_location = {London},
article_number = {1},
doi = {http://dx.doi.org/10.1038/s41598-020-66423-w},
keywords = {2-oxazoline; thin layers; cold plasma; DCSBD; cell adhesion; bioapplications},
language = {eng},
issn = {2045-2322},
journal = {Scientific Reports},
title = {Cold atmospheric pressure plasma: simple and efficient strategy for preparation of poly(2-oxazoline)-based coatings designed for biomedical applications},
url = {https://www.nature.com/articles/s41598-020-66423-w},
volume = {10},
year = {2020}
}
TY - JOUR
ID - 1671141
AU - Šrámková, Petra - Zahoranová, Anna - Kelar, Jakub - Kelar Tučeková, Zlata - Stupavská, Monika - Krumpolec, Richard - Jurmanová, Jana - Kováčik, Dušan - Černák, Mirko
PY - 2020
TI - Cold atmospheric pressure plasma: simple and efficient strategy for preparation of poly(2-oxazoline)-based coatings designed for biomedical applications
JF - Scientific Reports
VL - 10
IS - 1
SP - 1-13
EP - 1-13
PB - Nature Publishing Group
SN - 20452322
KW - 2-oxazoline
KW - thin layers
KW - cold plasma
KW - DCSBD
KW - cell adhesion
KW - bioapplications
UR - https://www.nature.com/articles/s41598-020-66423-w
L2 - https://www.nature.com/articles/s41598-020-66423-w
N2 - Poly(2-oxazolines) (POx) are an attractive material of choice for biocompatible and bioactive coatings in medical applications. To prepare POx coatings, the plasma polymerization represents a fast and facile approach that is surface-independent. However, unfavorable factors of this method such as using the low-pressure regimes and noble gases, or poor control over the resulting surface chemistry limit its utilization. Here, we propose to overcome these drawbacks by using well-defined POx-based copolymers prepared by living cationic polymerization as a starting material. Chemically inert polytetrafluoroethylene (PTFE) is selected as a substrate due to its beneficial features for medical applications. The deposited POx layer is additionally post-treated by non-equilibrium plasma generated at atmospheric pressure. For this purpose, diffuse coplanar surface barrier discharge (DCSBD) is used as a source of “cold” homogeneous plasma, as it is operating at atmospheric pressure even in ambient air. Prepared POx coatings possess hydrophilic nature with an achieved water contact angle of 60°, which is noticeably lower in comparison to the initial value of 106° for raw PTFE. Moreover, the increased fibroblasts adhesion in comparison to raw PTFE is achieved, and the physical and biological properties of the POx-modified surfaces remain stable for 30 days.
ER -
ŠRÁMKOVÁ, Petra, Anna ZAHORANOVÁ, Jakub KELAR, Zlata KELAR TUČEKOVÁ, Monika STUPAVSKÁ, Richard KRUMPOLEC, Jana JURMANOVÁ, Dušan KOVÁČIK and Mirko ČERNÁK. Cold atmospheric pressure plasma: simple and efficient strategy for preparation of poly(2-oxazoline)-based coatings designed for biomedical applications. \textit{Scientific Reports}. London: Nature Publishing Group, 2020, vol.~10, No~1, p.~1-13. ISSN~2045-2322. Available from: https://dx.doi.org/10.1038/s41598-020-66423-w.
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