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@article{1673161,
author = {Bořilová Linhartová, Petra and Daněk, Zdeněk and Deissová, Tereza and Hromčík, Filip and Lipový, Břetislav and Száraz, Dávid and Jánoš, Július and Fassmann, Antonín and Bartova, Jirina and Drizhal, Ivo and Izakovičová Hollá, Lydie},
article_location = {Basel},
article_number = {13},
doi = {http://dx.doi.org/10.3390/ijms21134728},
keywords = {aggressive periodontitis; oral bacteria; inflammation; interleukin; polymorphism; genetic predisposition},
language = {eng},
issn = {1422-0067},
journal = {International Journal of Molecular Sciences},
title = {Interleukin Gene Variability and Periodontal Bacteria in Patients with Generalized Aggressive Form of Periodontitis},
url = {https://www.mdpi.com/1422-0067/21/13/4728},
volume = {21},
year = {2020}
}
TY - JOUR
ID - 1673161
AU - Bořilová Linhartová, Petra - Daněk, Zdeněk - Deissová, Tereza - Hromčík, Filip - Lipový, Břetislav - Száraz, Dávid - Jánoš, Július - Fassmann, Antonín - Bartova, Jirina - Drizhal, Ivo - Izakovičová Hollá, Lydie
PY - 2020
TI - Interleukin Gene Variability and Periodontal Bacteria in Patients with Generalized Aggressive Form of Periodontitis
JF - International Journal of Molecular Sciences
VL - 21
IS - 13
SP - 1-24
EP - 1-24
PB - MDPI
SN - 14220067
KW - aggressive periodontitis
KW - oral bacteria
KW - inflammation
KW - interleukin
KW - polymorphism
KW - genetic predisposition
UR - https://www.mdpi.com/1422-0067/21/13/4728
L2 - https://www.mdpi.com/1422-0067/21/13/4728
N2 - Host genetic predispositions to dysregulated immune response can influence the development of the aggressive form of periodontitis (AgP) through susceptibility to oral dysbiosis and subsequent host-microbe interaction. This case-control study aimed to perform a multilocus analysis of functional variants in selected interleukin (IL) genes in patients with the generalized form of AgP in a homogenous population. Twelve polymorphisms inIL-1gene cluster,IL-6and its receptor,IL-10,IL-17A, andIL-18were determined in 91 AgP patients and 210 controls. Analysis of seven selected periodontal bacteria in subgingival sulci/pockets was performed with a commercial DNA-microarray kit in a subgroup of 76 individuals. The pilot in vitro study included stimulation of peripheral blood monocytes (PBMC) from 20 individuals with periodontal bacteria and measurement of IL-10 levels using the Luminex method. Only the unctional polymorphismIL-10-1087 A/G (rs1800896) and specificIL-10haplotypes were associated with the development of the disease (p< 0.05,P-corr> 0.05). Four bacterial species occurred more frequently in AgP than in controls (p< 0.01,P-corr< 0.05). Elevated IL-10 levels were found in AgP patients, carriers ofIL-10-1087GG genotype, and PBMCs stimulated by periodontal bacteria (p< 0.05,P-corr> 0.05). We therefore conclude that a combination of genetic predisposition to the altered expression ofIL-10and the presence of specific periodontal bacteria may contribute to Th1/Th2 balance disruption and AgP development.
ER -
BOŘILOVÁ LINHARTOVÁ, Petra, Zdeněk DANĚK, Tereza DEISSOVÁ, Filip HROMČÍK, Břetislav LIPOVÝ, Dávid SZÁRAZ, Július JÁNOŠ, Antonín FASSMANN, Jirina BARTOVA, Ivo DRIZHAL a Lydie IZAKOVIČOVÁ HOLLÁ. Interleukin Gene Variability and Periodontal Bacteria in Patients with Generalized Aggressive Form of Periodontitis. \textit{International Journal of Molecular Sciences}. Basel: MDPI, 2020, roč.~21, č.~13, s.~1-24. ISSN~1422-0067. Dostupné z: https://dx.doi.org/10.3390/ijms21134728.
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