Vitamin D levels in IBD: a randomised trial of weight-based
versus fixed dose vitamin D supplementation

J 2020

Vitamin D levels in IBD: a randomised trial of weight-based versus fixed dose vitamin D supplementation

KOJECKÝ, Vladimír, Jan MATOUS, Bohuslav KIANIČKA, Petr DITE, Zdena ZADOROVA et. al.

Základní údaje

Originální název

Vitamin D levels in IBD: a randomised trial of weight-based versus fixed dose vitamin D supplementation

Autoři

KOJECKÝ, Vladimír (203 Česká republika, domácí), Jan MATOUS (203 Česká republika), Bohuslav KIANIČKA (203 Česká republika, garant), Petr DITE (203 Česká republika), Zdena ZADOROVA (203 Česká republika), Jan KUBOVY (203 Česká republika), Martina HLOSTOVA (203 Česká republika) a Michal UHER (203 Česká republika, domácí)

Vydání

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, ABINGDON, TAYLOR & FRANCIS LTD, 2020, 0036-5521

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30219 Gastroenterology and hepatology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.423

Kód RIV

RIV/00216224:14110/20:00116133

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1080/00365521.2020.1774921

UT WoS

000545392100001

Klíčová slova anglicky

Inflammatory bowel disease; vitamin D deficiency; vitamin D intake; dietary supplements; body weight

Štítky

14119612, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 31. 8. 2020 10:43, Mgr. Tereza Miškechová

Anotace

V originále

Objectives:Body weight is one of the factors affecting blood levels of 25-hydroxyvitamin D (25OHD). The aim of this study was to establish whether a vitamin D (vitD) weight-based dosing is more appropriate to a fixed daily dose in patients with inflammatory bowel disease (IBD). Materials/methods:This was an open label randomised trial. Patients with IBD were assigned to receive oral cholecalciferol at a dose of 28 IU/kg (IU/kg) or 2000 IU per day (IU/day) for 12 weeks during winter months. 25OHD plasma levels and other biochemical parameters were measured at baseline and after supplementation period. The primary outcome measure was 25OHD level after a follow-up period. Results:A total of 173 patients were analysed. The mean BMI was 25.5 +/- 5.1 and initial mean 25OHD level was 62.7 +/- 25.5 nmol/l. A similar increase (9.7 +/- 26.9 vs 9.8 +/- 26.7 nmol/l) in 25OHD levels occurred both in IU/kg and IU/day group. The proportion of subjects with normal and sub-normal levels following the substitution was comparable irrespective of body weight. The change in 25OHD level correlated positively only with the dose of vitD (p < .001) and negatively with the baseline 25OHD level (p < .001). A sustained 25OHD level of 75 nmol/l corresponds with a calculated daily vitD dose of 2034 IU. Conclusions:Weight-based dosing of vitamin D is not superior to a fixed dose in order to maintain stable 25OHD levels in IBD patients. Cholecalciferol dose of 2,000 IU/day is safe and sufficient during winter period.

Citovat

KOJECKÝ, Vladimír, Jan MATOUS, Bohuslav KIANIČKA, Petr DITE, Zdena ZADOROVA, Jan KUBOVY, Martina HLOSTOVA a Michal UHER. Vitamin D levels in IBD: a randomised trial of weight-based versus fixed dose vitamin D supplementation. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY. ABINGDON: TAYLOR & FRANCIS LTD, 2020, roč. 55, č. 6, s. 671-676. ISSN 0036-5521. Dostupné z: https://dx.doi.org/10.1080/00365521.2020.1774921.

@article{1673167,
   author = {Kojecký, Vladimír and Matous, Jan and Kianička, Bohuslav and Dite, Petr and Zadorova, Zdena and Kubovy, Jan and Hlostova, Martina and Uher, Michal},
   article_location = {ABINGDON},
   article_number = {6},
   doi = {http://dx.doi.org/10.1080/00365521.2020.1774921},
   keywords = {Inflammatory bowel disease; vitamin D deficiency; vitamin D intake; dietary supplements; body weight},
   language = {eng},
   issn = {0036-5521},
   journal = {SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY},
   title = {Vitamin D levels in IBD: a randomised trial of weight-based versus fixed dose vitamin D supplementation},
   url = {https://www.tandfonline.com/doi/full/10.1080/00365521.2020.1774921},
   volume = {55},
   year = {2020}
}

TY  - JOUR
ID  - 1673167
AU  - Kojecký, Vladimír - Matous, Jan - Kianička, Bohuslav - Dite, Petr - Zadorova, Zdena - Kubovy, Jan - Hlostova, Martina - Uher, Michal
PY  - 2020
TI  - Vitamin D levels in IBD: a randomised trial of weight-based versus fixed dose vitamin D supplementation
JF  - SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
VL  - 55
IS  - 6
SP  - 671-676
EP  - 671-676
PB  - TAYLOR & FRANCIS LTD
SN  - 00365521
KW  - Inflammatory bowel disease
KW  - vitamin D deficiency
KW  - vitamin D intake
KW  - dietary supplements
KW  - body weight
UR  - https://www.tandfonline.com/doi/full/10.1080/00365521.2020.1774921
L2  - https://www.tandfonline.com/doi/full/10.1080/00365521.2020.1774921
N2  - Objectives:Body weight is one of the factors affecting blood levels of 25-hydroxyvitamin D (25OHD). The aim of this study was to establish whether a vitamin D (vitD) weight-based dosing is more appropriate to a fixed daily dose in patients with inflammatory bowel disease (IBD). Materials/methods:This was an open label randomised trial. Patients with IBD were assigned to receive oral cholecalciferol at a dose of 28 IU/kg (IU/kg) or 2000 IU per day (IU/day) for 12 weeks during winter months. 25OHD plasma levels and other biochemical parameters were measured at baseline and after supplementation period. The primary outcome measure was 25OHD level after a follow-up period. Results:A total of 173 patients were analysed. The mean BMI was 25.5 +/- 5.1 and initial mean 25OHD level was 62.7 +/- 25.5 nmol/l. A similar increase (9.7 +/- 26.9 vs 9.8 +/- 26.7 nmol/l) in 25OHD levels occurred both in IU/kg and IU/day group. The proportion of subjects with normal and sub-normal levels following the substitution was comparable irrespective of body weight. The change in 25OHD level correlated positively only with the dose of vitD (p < .001) and negatively with the baseline 25OHD level (p < .001). A sustained 25OHD level of 75 nmol/l corresponds with a calculated daily vitD dose of 2034 IU. Conclusions:Weight-based dosing of vitamin D is not superior to a fixed dose in order to maintain stable 25OHD levels in IBD patients. Cholecalciferol dose of 2,000 IU/day is safe and sufficient during winter period.
ER  -

KOJECKÝ, Vladimír, Jan MATOUS, Bohuslav KIANIČKA, Petr DITE, Zdena ZADOROVA, Jan KUBOVY, Martina HLOSTOVA a Michal UHER. Vitamin D levels in IBD: a randomised trial of weight-based versus fixed dose vitamin D supplementation. \textit{SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY}. ABINGDON: TAYLOR \&{} FRANCIS LTD, 2020, roč.~55, č.~6, s.~671-676. ISSN~0036-5521. Dostupné z: https://dx.doi.org/10.1080/00365521.2020.1774921.

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