Non-steroidal anti-inflammatory drugs in the pathophysiology of
vasospasms and delayed cerebral ischemia following subarachnoid
hemorrhage: a critical review

J 2021

Non-steroidal anti-inflammatory drugs in the pathophysiology of vasospasms and delayed cerebral ischemia following subarachnoid hemorrhage: a critical review

SOLÁR, Peter, Zdeněk MACKERLE, Marek JOUKAL a Radim JANČÁLEK

Základní údaje

Originální název

Non-steroidal anti-inflammatory drugs in the pathophysiology of vasospasms and delayed cerebral ischemia following subarachnoid hemorrhage: a critical review

Autoři

SOLÁR, Peter (703 Slovensko, domácí), Zdeněk MACKERLE (203 Česká republika, domácí), Marek JOUKAL (203 Česká republika, domácí) a Radim JANČÁLEK (203 Česká republika, garant, domácí)

Vydání

NEUROSURGICAL REVIEW, NEW YORK, SPRINGER, 2021, 0344-5607

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30103 Neurosciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.800

Kód RIV

RIV/00216224:14110/21:00120663

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1007/s10143-020-01276-5

UT WoS

000517727800002

Klíčová slova anglicky

Aneurysmal subarachnoid hemorrhage; Non-steroidal anti-inflammatory drugs; Vasospasms; Cerebral ischemia

Štítky

14110131, 14110514, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 7. 6. 2021 14:13, Mgr. Tereza Miškechová

Anotace

V originále

Aneurysmal subarachnoid hemorrhage (aSAH) is a life-threatening condition associated with the development of early brain injury (EBI) and delayed cerebral ischemia (DCI). Pharmacological treatment of vasospasm following aSAH currently mainly comprises nimodipine administration. In the past few years, many drugs that can potentially benefit cases of subarachnoid hemorrhage have become available. The objective of this review is to critically assess the effects of non-steroidal anti-inflammatory drugs (NSAIDs) following aSAH. A systematic literature review was conducted following PRISMA guidelines. The search was aimed at studies addressing aSAH and NSAIDs during the 2010 to 2019 period, and it yielded 13 articles. Following the application of search criteria, they were divided into two groups, one containing 6 clinical articles and the other containing 7 experimental articles on animal models of aSAH. Inflammatory cerebral changes after aneurysm rupture contribute to the development of EBI, DCI and cerebral vasospasm. It appears that NSAIDs (especially coxibs) are even more effective in reducing vasospasm than nimodipine. Other beneficial effects of NSAIDs include reduction in mortality, improved functional outcome and increased hypoaggregability. However, despite these positive effects, there is only one randomized, double-blind, placebo-controlled trial showing a tendency towards a better outcome with lower incidence of vasospasm or mortality in patients following aSAH.

Citovat

SOLÁR, Peter, Zdeněk MACKERLE, Marek JOUKAL a Radim JANČÁLEK. Non-steroidal anti-inflammatory drugs in the pathophysiology of vasospasms and delayed cerebral ischemia following subarachnoid hemorrhage: a critical review. NEUROSURGICAL REVIEW. NEW YORK: SPRINGER, 2021, roč. 44, č. 2, s. 649-658. ISSN 0344-5607. Dostupné z: https://dx.doi.org/10.1007/s10143-020-01276-5.

@article{1673732,
   author = {Solár, Peter and Mackerle, Zdeněk and Joukal, Marek and Jančálek, Radim},
   article_location = {NEW YORK},
   article_number = {2},
   doi = {http://dx.doi.org/10.1007/s10143-020-01276-5},
   keywords = {Aneurysmal subarachnoid hemorrhage; Non-steroidal anti-inflammatory drugs; Vasospasms; Cerebral ischemia},
   language = {eng},
   issn = {0344-5607},
   journal = {NEUROSURGICAL REVIEW},
   title = {Non-steroidal anti-inflammatory drugs in the pathophysiology of vasospasms and delayed cerebral ischemia following subarachnoid hemorrhage: a critical review},
   url = {https://link.springer.com/article/10.1007/s10143-020-01276-5},
   volume = {44},
   year = {2021}
}

TY  - JOUR
ID  - 1673732
AU  - Solár, Peter - Mackerle, Zdeněk - Joukal, Marek - Jančálek, Radim
PY  - 2021
TI  - Non-steroidal anti-inflammatory drugs in the pathophysiology of vasospasms and delayed cerebral ischemia following subarachnoid hemorrhage: a critical review
JF  - NEUROSURGICAL REVIEW
VL  - 44
IS  - 2
SP  - 649-658
EP  - 649-658
PB  - SPRINGER
SN  - 03445607
KW  - Aneurysmal subarachnoid hemorrhage
KW  - Non-steroidal anti-inflammatory drugs
KW  - Vasospasms
KW  - Cerebral ischemia
UR  - https://link.springer.com/article/10.1007/s10143-020-01276-5
L2  - https://link.springer.com/article/10.1007/s10143-020-01276-5
N2  - Aneurysmal subarachnoid hemorrhage (aSAH) is a life-threatening condition associated with the development of early brain injury (EBI) and delayed cerebral ischemia (DCI). Pharmacological treatment of vasospasm following aSAH currently mainly comprises nimodipine administration. In the past few years, many drugs that can potentially benefit cases of subarachnoid hemorrhage have become available. The objective of this review is to critically assess the effects of non-steroidal anti-inflammatory drugs (NSAIDs) following aSAH. A systematic literature review was conducted following PRISMA guidelines. The search was aimed at studies addressing aSAH and NSAIDs during the 2010 to 2019 period, and it yielded 13 articles. Following the application of search criteria, they were divided into two groups, one containing 6 clinical articles and the other containing 7 experimental articles on animal models of aSAH. Inflammatory cerebral changes after aneurysm rupture contribute to the development of EBI, DCI and cerebral vasospasm. It appears that NSAIDs (especially coxibs) are even more effective in reducing vasospasm than nimodipine. Other beneficial effects of NSAIDs include reduction in mortality, improved functional outcome and increased hypoaggregability. However, despite these positive effects, there is only one randomized, double-blind, placebo-controlled trial showing a tendency towards a better outcome with lower incidence of vasospasm or mortality in patients following aSAH.
ER  -

SOLÁR, Peter, Zdeněk MACKERLE, Marek JOUKAL a Radim JANČÁLEK. Non-steroidal anti-inflammatory drugs in the pathophysiology of vasospasms and delayed cerebral ischemia following subarachnoid hemorrhage: a critical review. \textit{NEUROSURGICAL REVIEW}. NEW YORK: SPRINGER, 2021, roč.~44, č.~2, s.~649-658. ISSN~0344-5607. Dostupné z: https://dx.doi.org/10.1007/s10143-020-01276-5.

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