Primary Mammary Organoid Model of Lactation and Involution

J 2020

Primary Mammary Organoid Model of Lactation and Involution

SUMBAL, Jakub, Aurelie CHICHE, Elsa CHARIFOU, Zuzana KOLEDOVÁ, Han LI et. al.

Základní údaje

Originální název

Primary Mammary Organoid Model of Lactation and Involution

Autoři

SUMBAL, Jakub (203 Česká republika, domácí), Aurelie CHICHE (250 Francie), Elsa CHARIFOU (250 Francie), Zuzana KOLEDOVÁ (703 Slovensko, garant, domácí) a Han LI (250 Francie)

Vydání

Frontiers in Cell and Developmental Biology, Lausanne, Frontiers Media S.A. 2020, 2296-634X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10605 Developmental biology

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 6.684

Kód RIV

RIV/00216224:14110/20:00116164

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.3389/fcell.2020.00068

UT WoS

000525631100001

Klíčová slova anglicky

3D culture; fibroblast growth factor 2; involution; lactation; mammary gland; milk production; organoid; prolactin

Štítky

14110517, CF CELLIM, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 4. 3. 2021 14:29, Mgr. Tereza Miškechová

Anotace

V originále

Mammary gland development occurs mainly after birth and is composed of three successive stages: puberty, pregnancy and lactation, and involution. These developmental stages are associated with major tissue remodeling, including extensive changes in mammary epithelium, as well as surrounding stroma. Three-dimensional (3D) mammary organoid culture has become an important tool in mammary gland biology and enabled invaluable discoveries on pubertal mammary branching morphogenesis and breast cancer. However, a suitable 3D organoid model recapitulating key aspects of lactation and involution has been missing. Here, we describe a robust and straightforward mouse mammary organoid system modeling lactation and involution-like process, which can be applied to study mechanisms of physiological mammary gland lactation and involution as well as pregnancy-associated breast cancer.

Návaznosti

MUNI/A/1382/2019, interní kód MU

Název: Zdroje pro tkáňové inženýrství 10 (Akronym: TissueEng 10)

Investor: Masarykova univerzita, Zdroje pro tkáňové inženýrství 10, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

MUNI/A/1565/2018, interní kód MU

Název: Zdroje pro tkáňové inženýrství 9 (Akronym: TissueEng 9)

Investor: Masarykova univerzita, Zdroje pro tkáňové inženýrství 9, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

MUNI/G/1446/2018, interní kód MU

Název: Deciphering the mechanisms of mammary epithelial branched pattern formation through iterative biological and mathematical modelling

Investor: Masarykova univerzita, Deciphering the mechanisms of mammary epithelial branched pattern formation through iterative biological and mathematical modelling, INTERDISCIPLINARY - Mezioborové výzkumné projekty

Citovat

SUMBAL, Jakub, Aurelie CHICHE, Elsa CHARIFOU, Zuzana KOLEDOVÁ a Han LI. Primary Mammary Organoid Model of Lactation and Involution. Frontiers in Cell and Developmental Biology. Lausanne: Frontiers Media S.A., 2020, roč. 8, MAR 2020, s. 1-13. ISSN 2296-634X. Dostupné z: https://dx.doi.org/10.3389/fcell.2020.00068.

@article{1673739,
   author = {Sumbal, Jakub and Chiche, Aurelie and Charifou, Elsa and Koledová, Zuzana and Li, Han},
   article_location = {Lausanne},
   article_number = {MAR 2020},
   doi = {http://dx.doi.org/10.3389/fcell.2020.00068},
   keywords = {3D culture; fibroblast growth factor 2; involution; lactation; mammary gland; milk production; organoid; prolactin},
   language = {eng},
   issn = {2296-634X},
   journal = {Frontiers in Cell and Developmental Biology},
   title = {Primary Mammary Organoid Model of Lactation and Involution},
   url = {https://www.frontiersin.org/articles/10.3389/fcell.2020.00068/full},
   volume = {8},
   year = {2020}
}

TY  - JOUR
ID  - 1673739
AU  - Sumbal, Jakub - Chiche, Aurelie - Charifou, Elsa - Koledová, Zuzana - Li, Han
PY  - 2020
TI  - Primary Mammary Organoid Model of Lactation and Involution
JF  - Frontiers in Cell and Developmental Biology
VL  - 8
IS  - MAR 2020
SP  - 1-13
EP  - 1-13
PB  - Frontiers Media S.A.
SN  - 2296634X
KW  - 3D culture
KW  - fibroblast growth factor 2
KW  - involution
KW  - lactation
KW  - mammary gland
KW  - milk production
KW  - organoid
KW  - prolactin
UR  - https://www.frontiersin.org/articles/10.3389/fcell.2020.00068/full
L2  - https://www.frontiersin.org/articles/10.3389/fcell.2020.00068/full
N2  - Mammary gland development occurs mainly after birth and is composed of three successive stages: puberty, pregnancy and lactation, and involution. These developmental stages are associated with major tissue remodeling, including extensive changes in mammary epithelium, as well as surrounding stroma. Three-dimensional (3D) mammary organoid culture has become an important tool in mammary gland biology and enabled invaluable discoveries on pubertal mammary branching morphogenesis and breast cancer. However, a suitable 3D organoid model recapitulating key aspects of lactation and involution has been missing. Here, we describe a robust and straightforward mouse mammary organoid system modeling lactation and involution-like process, which can be applied to study mechanisms of physiological mammary gland lactation and involution as well as pregnancy-associated breast cancer.
ER  -

SUMBAL, Jakub, Aurelie CHICHE, Elsa CHARIFOU, Zuzana KOLEDOVÁ a Han LI. Primary Mammary Organoid Model of Lactation and Involution. \textit{Frontiers in Cell and Developmental Biology}. Lausanne: Frontiers Media S.A., 2020, roč.~8, MAR 2020, s.~1-13. ISSN~2296-634X. Dostupné z: https://dx.doi.org/10.3389/fcell.2020.00068.

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