Genomic profile and immune contexture in colorectal
cancer-relevance for prognosis and immunotherapy

J 2021

Genomic profile and immune contexture in colorectal cancer-relevance for prognosis and immunotherapy

MERSAKOVA, Sandra, Zora LASABOVA, Jan STRNADEL, Michal KALMAN, Eva GABONOVA et. al.

Základní údaje

Originální název

Genomic profile and immune contexture in colorectal cancer-relevance for prognosis and immunotherapy

Autoři

MERSAKOVA, Sandra (703 Slovensko), Zora LASABOVA (703 Slovensko), Jan STRNADEL (703 Slovensko), Michal KALMAN (703 Slovensko), Eva GABONOVA (703 Slovensko), Peter SABAKA (703 Slovensko), Rachele CICCOCIOPPO (380 Itálie), Luis RODRIGO (724 Španělsko), Peter KRUŽLIAK (703 Slovensko, garant, domácí) a Peter MIKOLAJCIK (703 Slovensko)

Vydání

Clinical and Experimental Medicine, Milan, SPRINGER-VERLAG ITALIA SRL, 2021, 1591-8890

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30101 Human genetics

Stát vydavatele

Itálie

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 5.057

Kód RIV

RIV/00216224:14110/21:00120666

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1007/s10238-020-00649-w

UT WoS

000552931400002

Klíčová slova anglicky

Colorectal cancer (CRC); Genomic profile; Immune cells; Immunotherapy

Štítky

14110121, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 7. 6. 2021 13:50, Mgr. Tereza Miškechová

Anotace

V originále

Colorectal cancer (CRC) is one of the leading cancers in both genders. TNM staging system is still the most commonly used tumor classification and prognostic system. The disadvantage of TNM is that the prognostic information it provides is incomplete, and patients with the same histological tumor stages may differ significantly in the clinical outcome. Therefore, the identification of new prognostic parameters is crucial. The carcinogenic process that gives rise to an individual tumor is unique and tumor microenviroment should be taken into consideration. In CRC, T-cell infiltration is not homogenous, and recent studies are mostly focusing on memory T-cells and CD8 cells in predicting disease-free survival (DFS) and overall survival (OS). It seems that DFS and OS are not only dependent on microsatellite instable or stable status but mostly on the levels of expression of the immune signatures. Also, patients with high infiltration of cytotoxic and memory cells have significantly better outcome. This review consolidates current knowledge and recent research about importance of immune-cell-associated proteins, specific gene profiles of immune cells and immunotherapy in CRC. We also discussed cell-specific signatures in cancer treatment.

Citovat

MERSAKOVA, Sandra, Zora LASABOVA, Jan STRNADEL, Michal KALMAN, Eva GABONOVA, Peter SABAKA, Rachele CICCOCIOPPO, Luis RODRIGO, Peter KRUŽLIAK a Peter MIKOLAJCIK. Genomic profile and immune contexture in colorectal cancer-relevance for prognosis and immunotherapy. Clinical and Experimental Medicine. Milan: SPRINGER-VERLAG ITALIA SRL, 2021, roč. 21, č. 2, s. 195-204. ISSN 1591-8890. Dostupné z: https://dx.doi.org/10.1007/s10238-020-00649-w.

@article{1673997,
   author = {Mersakova, Sandra and Lasabova, Zora and Strnadel, Jan and Kalman, Michal and Gabonova, Eva and Sabaka, Peter and Ciccocioppo, Rachele and Rodrigo, Luis and Kružliak, Peter and Mikolajcik, Peter},
   article_location = {Milan},
   article_number = {2},
   doi = {http://dx.doi.org/10.1007/s10238-020-00649-w},
   keywords = {Colorectal cancer (CRC); Genomic profile; Immune cells; Immunotherapy},
   language = {eng},
   issn = {1591-8890},
   journal = {Clinical and Experimental Medicine},
   title = {Genomic profile and immune contexture in colorectal cancer-relevance for prognosis and immunotherapy},
   url = {https://link.springer.com/article/10.1007/s10238-020-00649-w},
   volume = {21},
   year = {2021}
}

TY  - JOUR
ID  - 1673997
AU  - Mersakova, Sandra - Lasabova, Zora - Strnadel, Jan - Kalman, Michal - Gabonova, Eva - Sabaka, Peter - Ciccocioppo, Rachele - Rodrigo, Luis - Kružliak, Peter - Mikolajcik, Peter
PY  - 2021
TI  - Genomic profile and immune contexture in colorectal cancer-relevance for prognosis and immunotherapy
JF  - Clinical and Experimental Medicine
VL  - 21
IS  - 2
SP  - 195-204
EP  - 195-204
PB  - SPRINGER-VERLAG ITALIA SRL
SN  - 15918890
KW  - Colorectal cancer (CRC)
KW  - Genomic profile
KW  - Immune cells
KW  - Immunotherapy
UR  - https://link.springer.com/article/10.1007/s10238-020-00649-w
L2  - https://link.springer.com/article/10.1007/s10238-020-00649-w
N2  - Colorectal cancer (CRC) is one of the leading cancers in both genders. TNM staging system is still the most commonly used tumor classification and prognostic system. The disadvantage of TNM is that the prognostic information it provides is incomplete, and patients with the same histological tumor stages may differ significantly in the clinical outcome. Therefore, the identification of new prognostic parameters is crucial. The carcinogenic process that gives rise to an individual tumor is unique and tumor microenviroment should be taken into consideration. In CRC, T-cell infiltration is not homogenous, and recent studies are mostly focusing on memory T-cells and CD8 cells in predicting disease-free survival (DFS) and overall survival (OS). It seems that DFS and OS are not only dependent on microsatellite instable or stable status but mostly on the levels of expression of the immune signatures. Also, patients with high infiltration of cytotoxic and memory cells have significantly better outcome. This review consolidates current knowledge and recent research about importance of immune-cell-associated proteins, specific gene profiles of immune cells and immunotherapy in CRC. We also discussed cell-specific signatures in cancer treatment.
ER  -

MERSAKOVA, Sandra, Zora LASABOVA, Jan STRNADEL, Michal KALMAN, Eva GABONOVA, Peter SABAKA, Rachele CICCOCIOPPO, Luis RODRIGO, Peter KRUŽLIAK a Peter MIKOLAJCIK. Genomic profile and immune contexture in colorectal cancer-relevance for prognosis and immunotherapy. \textit{Clinical and Experimental Medicine}. Milan: SPRINGER-VERLAG ITALIA SRL, 2021, roč.~21, č.~2, s.~195-204. ISSN~1591-8890. Dostupné z: https://dx.doi.org/10.1007/s10238-020-00649-w.

Podrobný výpis o publikaci