Prospective Multiparametric Magnetic Resonance Monitoring of
Changes in Lesions of Hyaline Cartilage of the Knee Joint After
Treatment by Microfractures and Implantation of Biological
Collagen Type I Matrix Implants

J 2021

Prospective Multiparametric Magnetic Resonance Monitoring of Changes in Lesions of Hyaline Cartilage of the Knee Joint After Treatment by Microfractures and Implantation of Biological Collagen Type I Matrix Implants

ŠPRLÁKOVÁ-PUKOVÁ, Andrea, Alena ŠTOURAČOVÁ, Martin REPKO, Eva KORIŤÁKOVÁ, Jaroslav TINTĚRA et. al.

Základní údaje

Originální název

Prospective Multiparametric Magnetic Resonance Monitoring of Changes in Lesions of Hyaline Cartilage of the Knee Joint After Treatment by Microfractures and Implantation of Biological Collagen Type I Matrix Implants

Autoři

ŠPRLÁKOVÁ-PUKOVÁ, Andrea (203 Česká republika, domácí), Alena ŠTOURAČOVÁ (203 Česká republika, domácí), Martin REPKO (203 Česká republika, domácí), Eva KORIŤÁKOVÁ (203 Česká republika, domácí), Jaroslav TINTĚRA (203 Česká republika), Marek DOSTÁL (203 Česká republika, domácí) a Tomáš OTAŠEVIČ (203 Česká republika, domácí)

Vydání

Academic Radiology, New York, Elsevier, 2021, 1076-6332

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30224 Radiology, nuclear medicine and medical imaging

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 5.482

Kód RIV

RIV/00216224:14110/21:00120667

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1016/j.acra.2020.05.030

UT WoS

000691198200018

Klíčová slova anglicky

Cartilage; Magnetic resonance imaging; Microfracture; Autologous matrix-induced chondrogenesis

Štítky

14110216, 14110217, 14119612, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 4. 11. 2021 10:44, Mgr. Tereza Miškechová

Anotace

V originále

Rationale and Objectives: This study's aims were to depict changes in cartilage quality after surgical intervention using magnetic reso-nance (MR) examination and in content of glycosaminoglycans chains (GAGs) after two types of surgeries -chondral defect treatment by microfractures and scaffold implantation in combination with microfractures. Materials and Methods: Twenty-five patients were studied: 14 with implants, 11 with microfractures. MR examination was made before surgery and 6, 12, and 18 months thereafter. Qualitative changes in cartilage were observed by means of delayed gadolinium enhanced magnetic resonance imaging of cartilage sequence using Gd-DTPA2-and Gd-DOTA. In each examination, GAGs content was deter-mined at three locations: the defect, its surroundings, and a non-load-bearing reference area. Results: Measured indices showed no statistically significant differences in changes within the defect area when comparing the two treat-ment types at individual time points of 6, 12, and 18 months. In the case of microfracture treatment, more substantial decrease in GAGs concentration occurred at month 6, whereas the greatest decline occurred at month 12 when using an implant. Change in GAGs content and decline in cartilage quality were substantial also in the reference area and close surroundings. Conclusions: Hyaline cartilage behaves as a unified whole, and change in GAGs content was marked also in locations with no morpho-logical damage. Over the monitored period, no statistically significant difference between treatment types was noted as measured by GAGs content in the defect or its close surroundings. dGEMRIC is suitable for monitoring cartilage quality even if use of Gd-DTPA2-is not possible, because comparable results were achieved using Gd-DOTA.

Citovat

ŠPRLÁKOVÁ-PUKOVÁ, Andrea, Alena ŠTOURAČOVÁ, Martin REPKO, Eva KORIŤÁKOVÁ, Jaroslav TINTĚRA, Marek DOSTÁL a Tomáš OTAŠEVIČ. Prospective Multiparametric Magnetic Resonance Monitoring of Changes in Lesions of Hyaline Cartilage of the Knee Joint After Treatment by Microfractures and Implantation of Biological Collagen Type I Matrix Implants. Academic Radiology. New York: Elsevier, 2021, roč. 28, č. 8, s. 1133-1141. ISSN 1076-6332. Dostupné z: https://dx.doi.org/10.1016/j.acra.2020.05.030.

@article{1674065,
   author = {ŠprlákováandPuková, Andrea and Štouračová, Alena and Repko, Martin and Koriťáková, Eva and Tintěra, Jaroslav and Dostál, Marek and Otaševič, Tomáš},
   article_location = {New York},
   article_number = {8},
   doi = {http://dx.doi.org/10.1016/j.acra.2020.05.030},
   keywords = {Cartilage; Magnetic resonance imaging; Microfracture; Autologous matrix-induced chondrogenesis},
   language = {eng},
   issn = {1076-6332},
   journal = {Academic Radiology},
   title = {Prospective Multiparametric Magnetic Resonance Monitoring of Changes in Lesions of Hyaline Cartilage of the Knee Joint After Treatment by Microfractures and Implantation of Biological Collagen Type I Matrix Implants},
   url = {https://www.sciencedirect.com/science/article/abs/pii/S1076633220303378},
   volume = {28},
   year = {2021}
}

TY  - JOUR
ID  - 1674065
AU  - Šprláková-Puková, Andrea - Štouračová, Alena - Repko, Martin - Koriťáková, Eva - Tintěra, Jaroslav - Dostál, Marek - Otaševič, Tomáš
PY  - 2021
TI  - Prospective Multiparametric Magnetic Resonance Monitoring of Changes in Lesions of Hyaline Cartilage of the Knee Joint After Treatment by Microfractures and Implantation of Biological Collagen Type I Matrix Implants
JF  - Academic Radiology
VL  - 28
IS  - 8
SP  - 1133-1141
EP  - 1133-1141
PB  - Elsevier
SN  - 10766332
KW  - Cartilage
KW  - Magnetic resonance imaging
KW  - Microfracture
KW  - Autologous matrix-induced chondrogenesis
UR  - https://www.sciencedirect.com/science/article/abs/pii/S1076633220303378
N2  - Rationale and Objectives: This study's aims were to depict changes in cartilage quality after surgical intervention using magnetic reso-nance (MR) examination and in content of glycosaminoglycans chains (GAGs) after two types of surgeries -chondral defect treatment by microfractures and scaffold implantation in combination with microfractures. Materials and Methods: Twenty-five patients were studied: 14 with implants, 11 with microfractures. MR examination was made before surgery and 6, 12, and 18 months thereafter. Qualitative changes in cartilage were observed by means of delayed gadolinium enhanced magnetic resonance imaging of cartilage sequence using Gd-DTPA2-and Gd-DOTA. In each examination, GAGs content was deter-mined at three locations: the defect, its surroundings, and a non-load-bearing reference area. Results: Measured indices showed no statistically significant differences in changes within the defect area when comparing the two treat-ment types at individual time points of 6, 12, and 18 months. In the case of microfracture treatment, more substantial decrease in GAGs concentration occurred at month 6, whereas the greatest decline occurred at month 12 when using an implant. Change in GAGs content and decline in cartilage quality were substantial also in the reference area and close surroundings. Conclusions: Hyaline cartilage behaves as a unified whole, and change in GAGs content was marked also in locations with no morpho-logical damage. Over the monitored period, no statistically significant difference between treatment types was noted as measured by GAGs content in the defect or its close surroundings. dGEMRIC is suitable for monitoring cartilage quality even if use of Gd-DTPA2-is not possible, because comparable results were achieved using Gd-DOTA.
ER  -

ŠPRLÁKOVÁ-PUKOVÁ, Andrea, Alena ŠTOURAČOVÁ, Martin REPKO, Eva KORIŤÁKOVÁ, Jaroslav TINTĚRA, Marek DOSTÁL a Tomáš OTAŠEVIČ. Prospective Multiparametric Magnetic Resonance Monitoring of Changes in Lesions of Hyaline Cartilage of the Knee Joint After Treatment by Microfractures and Implantation of Biological Collagen Type I Matrix Implants. \textit{Academic Radiology}. New York: Elsevier, 2021, roč.~28, č.~8, s.~1133-1141. ISSN~1076-6332. Dostupné z: https://dx.doi.org/10.1016/j.acra.2020.05.030.

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