No Evidence of Persistence or Inheritance of Mitochondrial DNA
Copy Number in Holocaust Survivors and Their Descendants

J 2020

No Evidence of Persistence or Inheritance of Mitochondrial DNA Copy Number in Holocaust Survivors and Their Descendants

CAI, Na, Monika FŇAŠKOVÁ, Klára KONEČNÁ, Miloslava FOJTOVÁ, Jiří FAJKUS et. al.

Základní údaje

Originální název

No Evidence of Persistence or Inheritance of Mitochondrial DNA Copy Number in Holocaust Survivors and Their Descendants

Autoři

CAI, Na, Monika FŇAŠKOVÁ (203 Česká republika, domácí), Klára KONEČNÁ (203 Česká republika, domácí), Miloslava FOJTOVÁ (203 Česká republika, domácí), Jiří FAJKUS (203 Česká republika, domácí), Eve COOMBER, Stephen WATT, Nicole SORANZO, Marek PREISS (203 Česká republika, domácí) a Ivan REKTOR (203 Česká republika, garant, domácí)

Vydání

FRONTIERS IN GENETICS, LAUSANNE, FRONTIERS MEDIA SA, 2020, 1664-8021

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30101 Human genetics

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.599

Kód RIV

RIV/00216224:14740/20:00116207

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.3389/fgene.2020.00087

UT WoS

000525236500001

Klíčová slova anglicky

mitochondrial DNA; posttraumatic stress disorder; copy number variation; quantitative PCR; Holocaust-psychic trauma

Štítky

14110127, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 6. 4. 2021 10:46, Mgr. Pavla Foltynová, Ph.D.

Anotace

V originále

Mitochondrial DNA copy number has been previously shown to be elevated with severe and chronic stress, as well as stress-related pathology like Major Depressive Disorder (MDD) and post-traumatic stress disorder (PTSD). While experimental data point to likely recovery of mtDNA copy number changes after the stressful event, time needed for full recovery and whether it can be achieved are still unknown. Further, while it has been shown that stress-related mtDNA elevation affects multiple tissues, its specific consequences for oogenesis and maternal inheritance of mtDNA has never been explored. In this study, we used qPCR to quantify mtDNA copy number in 15 Holocaust survivors and 102 of their second- and third-generation descendants from the Czech Republic, many of whom suffer from PTSD, and compared them to controls in the respective generations. We found no significant difference in mtDNA copy number in the Holocaust survivors compared to controls, whether they have PTSD or not, and no significant elevation in descendants of female Holocaust survivors as compared to descendants of male survivors or controls. Our results showed no evidence of persistence or inheritance of mtDNA changes in Holocaust survivors, though that does not rule out effects in other tissues or mitigating mechanism for such changes.

Návaznosti

LQ1601, projekt VaV

Název: CEITEC 2020 (Akronym: CEITEC2020)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CEITEC 2020

NV18-04-00559, projekt VaV

Název: Neurobiologické a psychologické markery reakce na extrémní stres a jeho dopad na potomky - třígenerační studie přeživších holokaust a jejich potomků

Investor: Ministerstvo zdravotnictví ČR, Neurobiologické a psychologické markery reakce na extrémní stres a dopad na generace potomků - třígenerační studie přeživších holokaust a jejich potomků

Citovat

CAI, Na, Monika FŇAŠKOVÁ, Klára KONEČNÁ, Miloslava FOJTOVÁ, Jiří FAJKUS, Eve COOMBER, Stephen WATT, Nicole SORANZO, Marek PREISS a Ivan REKTOR. No Evidence of Persistence or Inheritance of Mitochondrial DNA Copy Number in Holocaust Survivors and Their Descendants. FRONTIERS IN GENETICS. LAUSANNE: FRONTIERS MEDIA SA, 2020, roč. 11, 03 March 2020, s. 87-98. ISSN 1664-8021. Dostupné z: https://dx.doi.org/10.3389/fgene.2020.00087.

@article{1674167,
   author = {Cai, Na and Fňašková, Monika and Konečná, Klára and Fojtová, Miloslava and Fajkus, Jiří and Coomber, Eve and Watt, Stephen and Soranzo, Nicole and Preiss, Marek and Rektor, Ivan},
   article_location = {LAUSANNE},
   article_number = {03 March 2020},
   doi = {http://dx.doi.org/10.3389/fgene.2020.00087},
   keywords = {mitochondrial DNA; posttraumatic stress disorder; copy number variation; quantitative PCR; Holocaust-psychic trauma},
   language = {eng},
   issn = {1664-8021},
   journal = {FRONTIERS IN GENETICS},
   title = {No Evidence of Persistence or Inheritance of Mitochondrial DNA Copy Number in Holocaust Survivors and Their Descendants},
   url = {https://pubmed.ncbi.nlm.nih.gov/32211017/},
   volume = {11},
   year = {2020}
}

TY  - JOUR
ID  - 1674167
AU  - Cai, Na - Fňašková, Monika - Konečná, Klára - Fojtová, Miloslava - Fajkus, Jiří - Coomber, Eve - Watt, Stephen - Soranzo, Nicole - Preiss, Marek - Rektor, Ivan
PY  - 2020
TI  - No Evidence of Persistence or Inheritance of Mitochondrial DNA Copy Number in Holocaust Survivors and Their Descendants
JF  - FRONTIERS IN GENETICS
VL  - 11
IS  - 03 March 2020
SP  - 87
EP  - 87
PB  - FRONTIERS MEDIA SA
SN  - 16648021
KW  - mitochondrial DNA
KW  - posttraumatic stress disorder
KW  - copy number variation
KW  - quantitative PCR
KW  - Holocaust-psychic trauma
UR  - https://pubmed.ncbi.nlm.nih.gov/32211017/
L2  - https://pubmed.ncbi.nlm.nih.gov/32211017/
N2  - Mitochondrial DNA copy number has been previously shown to be elevated with severe and chronic stress, as well as stress-related pathology like Major Depressive Disorder (MDD) and post-traumatic stress disorder (PTSD). While experimental data point to likely recovery of mtDNA copy number changes after the stressful event, time needed for full recovery and whether it can be achieved are still unknown. Further, while it has been shown that stress-related mtDNA elevation affects multiple tissues, its specific consequences for oogenesis and maternal inheritance of mtDNA has never been explored. In this study, we used qPCR to quantify mtDNA copy number in 15 Holocaust survivors and 102 of their second- and third-generation descendants from the Czech Republic, many of whom suffer from PTSD, and compared them to controls in the respective generations. We found no significant difference in mtDNA copy number in the Holocaust survivors compared to controls, whether they have PTSD or not, and no significant elevation in descendants of female Holocaust survivors as compared to descendants of male survivors or controls. Our results showed no evidence of persistence or inheritance of mtDNA changes in Holocaust survivors, though that does not rule out effects in other tissues or mitigating mechanism for such changes.
ER  -

CAI, Na, Monika FŇAŠKOVÁ, Klára KONEČNÁ, Miloslava FOJTOVÁ, Jiří FAJKUS, Eve COOMBER, Stephen WATT, Nicole SORANZO, Marek PREISS a Ivan REKTOR. No Evidence of Persistence or Inheritance of Mitochondrial DNA Copy Number in Holocaust Survivors and Their Descendants. \textit{FRONTIERS IN GENETICS}. LAUSANNE: FRONTIERS MEDIA SA, 2020, roč.~11, 03 March 2020, s.~87-98. ISSN~1664-8021. Dostupné z: https://dx.doi.org/10.3389/fgene.2020.00087.

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