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@article{1674167,
author = {Cai, Na and Fňašková, Monika and Konečná, Klára and Fojtová, Miloslava and Fajkus, Jiří and Coomber, Eve and Watt, Stephen and Soranzo, Nicole and Preiss, Marek and Rektor, Ivan},
article_location = {LAUSANNE},
article_number = {03 March 2020},
doi = {http://dx.doi.org/10.3389/fgene.2020.00087},
keywords = {mitochondrial DNA; posttraumatic stress disorder; copy number variation; quantitative PCR; Holocaust-psychic trauma},
language = {eng},
issn = {1664-8021},
journal = {FRONTIERS IN GENETICS},
title = {No Evidence of Persistence or Inheritance of Mitochondrial DNA Copy Number in Holocaust Survivors and Their Descendants},
url = {https://pubmed.ncbi.nlm.nih.gov/32211017/},
volume = {11},
year = {2020}
}
TY - JOUR
ID - 1674167
AU - Cai, Na - Fňašková, Monika - Konečná, Klára - Fojtová, Miloslava - Fajkus, Jiří - Coomber, Eve - Watt, Stephen - Soranzo, Nicole - Preiss, Marek - Rektor, Ivan
PY - 2020
TI - No Evidence of Persistence or Inheritance of Mitochondrial DNA Copy Number in Holocaust Survivors and Their Descendants
JF - FRONTIERS IN GENETICS
VL - 11
IS - 03 March 2020
SP - 87
EP - 87
PB - FRONTIERS MEDIA SA
SN - 16648021
KW - mitochondrial DNA
KW - posttraumatic stress disorder
KW - copy number variation
KW - quantitative PCR
KW - Holocaust-psychic trauma
UR - https://pubmed.ncbi.nlm.nih.gov/32211017/
L2 - https://pubmed.ncbi.nlm.nih.gov/32211017/
N2 - Mitochondrial DNA copy number has been previously shown to be elevated with severe and chronic stress, as well as stress-related pathology like Major Depressive Disorder (MDD) and post-traumatic stress disorder (PTSD). While experimental data point to likely recovery of mtDNA copy number changes after the stressful event, time needed for full recovery and whether it can be achieved are still unknown. Further, while it has been shown that stress-related mtDNA elevation affects multiple tissues, its specific consequences for oogenesis and maternal inheritance of mtDNA has never been explored. In this study, we used qPCR to quantify mtDNA copy number in 15 Holocaust survivors and 102 of their second- and third-generation descendants from the Czech Republic, many of whom suffer from PTSD, and compared them to controls in the respective generations. We found no significant difference in mtDNA copy number in the Holocaust survivors compared to controls, whether they have PTSD or not, and no significant elevation in descendants of female Holocaust survivors as compared to descendants of male survivors or controls. Our results showed no evidence of persistence or inheritance of mtDNA changes in Holocaust survivors, though that does not rule out effects in other tissues or mitigating mechanism for such changes.
ER -
CAI, Na, Monika FŇAŠKOVÁ, Klára KONEČNÁ, Miloslava FOJTOVÁ, Jiří FAJKUS, Eve COOMBER, Stephen WATT, Nicole SORANZO, Marek PREISS a Ivan REKTOR. No Evidence of Persistence or Inheritance of Mitochondrial DNA Copy Number in Holocaust Survivors and Their Descendants. \textit{FRONTIERS IN GENETICS}. LAUSANNE: FRONTIERS MEDIA SA, 2020, roč.~11, 03 March 2020, s.~87-98. ISSN~1664-8021. Dostupné z: https://dx.doi.org/10.3389/fgene.2020.00087.
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