Sight-threatening Complication of Cicatricial Ectropion in a
Patient with Lamellar Ichthyosis - Case Report

J 2020

Sight-threatening Complication of Cicatricial Ectropion in a Patient with Lamellar Ichthyosis - Case Report

RYBÁROVÁ, Natália, Blanka PINKOVÁ, Hana DOŠKOVÁ a Eva VLKOVÁ

Základní údaje

Originální název

Sight-threatening Complication of Cicatricial Ectropion in a Patient with Lamellar Ichthyosis - Case Report

Autoři

RYBÁROVÁ, Natália (703 Slovensko, domácí), Blanka PINKOVÁ (203 Česká republika, domácí), Hana DOŠKOVÁ (203 Česká republika) a Eva VLKOVÁ (203 Česká republika, domácí)

Vydání

Acta Dermatovenerologica Croatica, Zagreb, Croatian Dermatovenerological Society, 2020, 1330-027X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30216 Dermatology and venereal diseases

Stát vydavatele

Chorvatsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 1.256

Kód RIV

RIV/00216224:14110/20:00116226

Organizační jednotka

Lékařská fakulta

UT WoS

000582702600005

Klíčová slova anglicky

ichthyosis; corneal perforation; ectropion; penetrating keratoplasty

Štítky

14110219, 14110317, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 11. 11. 2020 11:04, Mgr. Tereza Miškechová

Anotace

V originále

We report a case of lamellar ichthyosis and sight-threatening complications of cicatricial ectropion in an adult male patient which was sur- gically managed with tectonic penetrating keratoplasty. We present a case of autosomal-recessive lamellar ichthyosis in a 47-year-old man who was re- ferred to our outpatient eye clinic for treatment of primary keratouveitis of the right eye with keratolysis and exudation in the anterior chamber. A di- agnosis of cicatricial ectropion with serious lagophthalmos was established on examination. The patient underwent tectonic penetrating keratoplasty, cataract extraction, and intra-ocular lens placement with no perioperative complications. The patient was subsequently treated with oral fluconazole 200 mg once daily for 12 days due to a positive fungal culture for Candida albicans and systemic oral acyclovir 250 mg 3 times per day for 12 days as pro- phylaxis for a labial herpetic infection. Post-operative complications included corneal rejection and nonhealing neurotropic epithelial defect of the graft. Long-term treatment with topical cyclosporine (Ikervis®) and dexametha- sone led to resolution of the corneal rejection. Lubrication with artificial tears containing hyaluronic acid, perfluorohexyl octane (Evotears®), and vitamin A ointment led to symptomatic relief of dry eye disease. The patient was re- ferred to a dermatologist and was started on systemic retinoid acitretin at a dose of 0.5 mg/kg per day. Ten months after surgery, the patient’s visual acuity was 0.1 based on the Snellen chart and the corneal graft was stable. Infection in the cornea can rapidly progress to corneal melting in patients with severe cicatricial ectropion. A good patient outcome depends on the interdisciplinary approach to patient management by the ophthalmologist, dermatologist, and plastic surgeon.

Citovat

RYBÁROVÁ, Natália, Blanka PINKOVÁ, Hana DOŠKOVÁ a Eva VLKOVÁ. Sight-threatening Complication of Cicatricial Ectropion in a Patient with Lamellar Ichthyosis - Case Report. Acta Dermatovenerologica Croatica. Zagreb: Croatian Dermatovenerological Society, 2020, roč. 28, č. 1, s. 29-33. ISSN 1330-027X.

@article{1674636,
   author = {Rybárová, Natália and Pinková, Blanka and Došková, Hana and Vlková, Eva},
   article_location = {Zagreb},
   article_number = {1},
   keywords = {ichthyosis; corneal perforation; ectropion; penetrating keratoplasty},
   language = {eng},
   issn = {1330-027X},
   journal = {Acta Dermatovenerologica Croatica},
   title = {Sight-threatening Complication of Cicatricial Ectropion in a Patient with Lamellar Ichthyosis - Case Report},
   url = {https://pubmed.ncbi.nlm.nih.gov/32650848/},
   volume = {28},
   year = {2020}
}

TY  - JOUR
ID  - 1674636
AU  - Rybárová, Natália - Pinková, Blanka - Došková, Hana - Vlková, Eva
PY  - 2020
TI  - Sight-threatening Complication of Cicatricial Ectropion in a Patient with Lamellar Ichthyosis - Case Report
JF  - Acta Dermatovenerologica Croatica
VL  - 28
IS  - 1
SP  - 29-33
EP  - 29-33
PB  - Croatian Dermatovenerological Society
SN  - 1330027X
KW  - ichthyosis
KW  - corneal perforation
KW  - ectropion
KW  - penetrating keratoplasty
UR  - https://pubmed.ncbi.nlm.nih.gov/32650848/
L2  - https://pubmed.ncbi.nlm.nih.gov/32650848/
N2  - We report a case of lamellar ichthyosis and sight-threatening complications of cicatricial ectropion in an adult male patient which was sur- gically managed with tectonic penetrating keratoplasty. We present a case of autosomal-recessive lamellar ichthyosis in a 47-year-old man who was re- ferred to our outpatient eye clinic for treatment of primary keratouveitis of the right eye with keratolysis and exudation in the anterior chamber. A di- agnosis of cicatricial ectropion with serious lagophthalmos was established on examination. The patient underwent tectonic penetrating keratoplasty, cataract extraction, and intra-ocular lens placement with no perioperative complications. The patient was subsequently treated with oral fluconazole 200 mg once daily for 12 days due to a positive fungal culture for Candida albicans and systemic oral acyclovir 250 mg 3 times per day for 12 days as pro- phylaxis for a labial herpetic infection. Post-operative complications included corneal rejection and nonhealing neurotropic epithelial defect of the graft. Long-term treatment with topical cyclosporine (Ikervis®) and dexametha- sone led to resolution of the corneal rejection. Lubrication with artificial tears containing hyaluronic acid, perfluorohexyl octane (Evotears®), and vitamin A ointment led to symptomatic relief of dry eye disease. The patient was re- ferred to a dermatologist and was started on systemic retinoid acitretin at a dose of 0.5 mg/kg per day. Ten months after surgery, the patient’s visual acuity was 0.1 based on the Snellen chart and the corneal graft was stable. Infection in the cornea can rapidly progress to corneal melting in patients with severe cicatricial ectropion. A good patient outcome depends on the interdisciplinary approach to patient management by the ophthalmologist, dermatologist, and plastic surgeon.
ER  -

RYBÁROVÁ, Natália, Blanka PINKOVÁ, Hana DOŠKOVÁ a Eva VLKOVÁ. Sight-threatening Complication of Cicatricial Ectropion in a Patient with Lamellar Ichthyosis - Case Report. \textit{Acta Dermatovenerologica Croatica}. Zagreb: Croatian Dermatovenerological Society, 2020, roč.~28, č.~1, s.~29-33. ISSN~1330-027X.

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