Ring-Substituted 1-Hydroxynaphthalene-2-Carboxanilides Inhibit
Proliferation and Trigger Mitochondria-Mediated Apoptosis

J 2020

Ring-Substituted 1-Hydroxynaphthalene-2-Carboxanilides Inhibit Proliferation and Trigger Mitochondria-Mediated Apoptosis

KAUEROVÁ, Tereza, Tomáš GONĚC, Josef JAMPÍLEK, Susanne HAFNER, Ann-Kathrin GAISER et. al.

Základní údaje

Originální název

Ring-Substituted 1-Hydroxynaphthalene-2-Carboxanilides Inhibit Proliferation and Trigger Mitochondria-Mediated Apoptosis

Autoři

KAUEROVÁ, Tereza (203 Česká republika, domácí), Tomáš GONĚC (203 Česká republika, domácí), Josef JAMPÍLEK (703 Slovensko), Susanne HAFNER (276 Německo), Ann-Kathrin GAISER (276 Německo), Tatiana SYROVETS (276 Německo), Radek FEDR (203 Česká republika), Karel SOUČEK (203 Česká republika) a Peter KOLLÁR (203 Česká republika, garant, domácí)

Vydání

International Journal of Molecular Sciences, Basel, Multidisciplinary Digital Publishing Institute, 2020, 1422-0067

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

Odkaz na webovou stránku s dostupným plným textem výsledku.

Impakt faktor

Impact factor: 5.923

Kód RIV

RIV/00216224:14160/20:00116289

Organizační jednotka

Farmaceutická fakulta

DOI

http://dx.doi.org/10.3390/ijms21103416

UT WoS

000539312100012

Klíčová slova česky

salicylanilidy; hydroxynaftalenkarboxamidy; apoptóza; buněčný cyklus; antiproliferativní účinek

Klíčová slova anglicky

salicylanilides; hydroxynaphthalene carboxamides; apoptosis; cell cycle; antiproliferative effect

Štítky

rivok, ÚChL, ÚFTo

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 22. 3. 2021 12:59, Mgr. Hana Hurtová

Anotace

V originále

Ring-substituted 1-hydroxynaphthalene-2-carboxanilides were previously investigated for their antimycobacterial properties. In our study, we have shown their antiproliferative and cell death-inducing effects in cancer cell lines. Cell proliferation and viability were assessed by WST-1 assay and a dye exclusion test, respectively. Cell cycle distribution, phosphatidylserine externalization, levels of reactive oxygen or nitrogen species (RONS), mitochondrial membrane depolarization, and release of cytochrome c were estimated by flow cytometry. Levels of regulatory proteins were determined by Western blotting. Our data suggest that the ability to inhibit the proliferation of THP-1 or MCF-7 cells might be referred to meta- or para-substituted derivatives with electron-withdrawing groups -F, -Br, or -CF3 at anilide moiety. This effect was accompanied by accumulation of cells in G1 phase. Compound 10 also induced apoptosis in THP-1 cells in association with a loss of mitochondrial membrane potential and production of mitochondrial superoxide. Our study provides a new insight into the action of salicylanilide derivatives, hydroxynaphthalene carboxamides, in cancer cells. Thus, their structure merits further investigation as a model moiety of new small-molecule compounds with potential anticancer properties.

Citovat

KAUEROVÁ, Tereza, Tomáš GONĚC, Josef JAMPÍLEK, Susanne HAFNER, Ann-Kathrin GAISER, Tatiana SYROVETS, Radek FEDR, Karel SOUČEK a Peter KOLLÁR. Ring-Substituted 1-Hydroxynaphthalene-2-Carboxanilides Inhibit Proliferation and Trigger Mitochondria-Mediated Apoptosis. International Journal of Molecular Sciences. Basel: Multidisciplinary Digital Publishing Institute, 2020, roč. 21, č. 10, s. 1-17. ISSN 1422-0067. Dostupné z: https://dx.doi.org/10.3390/ijms21103416.

@article{1675888,
   author = {Kauerová, Tereza and Goněc, Tomáš and Jampílek, Josef and Hafner, Susanne and Gaiser, AnnandKathrin and Syrovets, Tatiana and Fedr, Radek and Souček, Karel and Kollár, Peter},
   article_location = {Basel},
   article_number = {10},
   doi = {http://dx.doi.org/10.3390/ijms21103416},
   keywords = {salicylanilides; hydroxynaphthalene carboxamides; apoptosis; cell cycle; antiproliferative effect},
   language = {eng},
   issn = {1422-0067},
   journal = {International Journal of Molecular Sciences},
   title = {Ring-Substituted 1-Hydroxynaphthalene-2-Carboxanilides Inhibit Proliferation and Trigger Mitochondria-Mediated Apoptosis},
   url = {https://www.mdpi.com/1422-0067/21/10/3416/htm},
   volume = {21},
   year = {2020}
}

TY  - JOUR
ID  - 1675888
AU  - Kauerová, Tereza - Goněc, Tomáš - Jampílek, Josef - Hafner, Susanne - Gaiser, Ann-Kathrin - Syrovets, Tatiana - Fedr, Radek - Souček, Karel - Kollár, Peter
PY  - 2020
TI  - Ring-Substituted 1-Hydroxynaphthalene-2-Carboxanilides Inhibit Proliferation and Trigger Mitochondria-Mediated Apoptosis
JF  - International Journal of Molecular Sciences
VL  - 21
IS  - 10
SP  - 1-17
EP  - 1-17
PB  - Multidisciplinary Digital Publishing Institute
SN  - 14220067
KW  - salicylanilides
KW  - hydroxynaphthalene carboxamides
KW  - apoptosis
KW  - cell cycle
KW  - antiproliferative effect
UR  - https://www.mdpi.com/1422-0067/21/10/3416/htm
L2  - https://www.mdpi.com/1422-0067/21/10/3416/htm
N2  - Ring-substituted 1-hydroxynaphthalene-2-carboxanilides were previously investigated for their antimycobacterial properties. In our study, we have shown their antiproliferative and cell death-inducing effects in cancer cell lines. Cell proliferation and viability were assessed by WST-1 assay and a dye exclusion test, respectively. Cell cycle distribution, phosphatidylserine externalization, levels of reactive oxygen or nitrogen species (RONS), mitochondrial membrane depolarization, and release of cytochrome c were estimated by flow cytometry. Levels of regulatory proteins were determined by Western blotting. Our data suggest that the ability to inhibit the proliferation of THP-1 or MCF-7 cells might be referred to meta- or para-substituted derivatives with electron-withdrawing groups -F, -Br, or -CF3 at anilide moiety. This effect was accompanied by accumulation of cells in G1 phase. Compound 10 also induced apoptosis in THP-1 cells in association with a loss of mitochondrial membrane potential and production of mitochondrial superoxide. Our study provides a new insight into the action of salicylanilide derivatives, hydroxynaphthalene carboxamides, in cancer cells. Thus, their structure merits further investigation as a model moiety of new small-molecule compounds with potential anticancer properties.
ER  -

KAUEROVÁ, Tereza, Tomáš GONĚC, Josef JAMPÍLEK, Susanne HAFNER, Ann-Kathrin GAISER, Tatiana SYROVETS, Radek FEDR, Karel SOUČEK a Peter KOLLÁR. Ring-Substituted 1-Hydroxynaphthalene-2-Carboxanilides Inhibit Proliferation and Trigger Mitochondria-Mediated Apoptosis. \textit{International Journal of Molecular Sciences}. Basel: Multidisciplinary Digital Publishing Institute, 2020, roč.~21, č.~10, s.~1-17. ISSN~1422-0067. Dostupné z: https://dx.doi.org/10.3390/ijms21103416.

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