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@article{1676537,
author = {Sandecká, Viera and Adam, Zdeněk and Krejčí, Marta and Štork, Martin and Řehák, Zdeněk and Koukalová, Renata and Ševčíková, Sabina and Brožová, Lucie and Král, Zdeněk and Mayer, Jiří and Pour, Luděk},
article_location = {Bratislava},
article_number = {4},
doi = {http://dx.doi.org/10.4149/neo_2020_191104N1137},
keywords = {monoclonal gammopathy; cancer; multiple myeloma; PET/CT},
language = {eng},
issn = {0028-2685},
journal = {Neoplasma},
title = {Diagnostic relevance of 18F-FDG PET/CT in newly diagnosed patients with monoclonal gammopathy of undetermined significance (MGUS): Single-center experience},
url = {http://www.elis.sk/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=6768&category_id=160&option=com_virtuemart&vmcchk=1&Itemid=1},
volume = {67},
year = {2020}
}
TY - JOUR
ID - 1676537
AU - Sandecká, Viera - Adam, Zdeněk - Krejčí, Marta - Štork, Martin - Řehák, Zdeněk - Koukalová, Renata - Ševčíková, Sabina - Brožová, Lucie - Král, Zdeněk - Mayer, Jiří - Pour, Luděk
PY - 2020
TI - Diagnostic relevance of 18F-FDG PET/CT in newly diagnosed patients with monoclonal gammopathy of undetermined significance (MGUS): Single-center experience
JF - Neoplasma
VL - 67
IS - 4
SP - 939-945
EP - 939-945
PB - Slovenská akademie vied
SN - 00282685
KW - monoclonal gammopathy
KW - cancer
KW - multiple myeloma
KW - PET/CT
UR - http://www.elis.sk/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=6768&category_id=160&option=com_virtuemart&vmcchk=1&Itemid=1
L2 - http://www.elis.sk/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=6768&category_id=160&option=com_virtuemart&vmcchk=1&Itemid=1
N2 - Monoclonal gammopathy of undetermined significance (MGUS) is a known precursor of more serious cancers, such as multiple myeloma (MM), Waldenstrom macroglobulinemia (MW) and other lymphoproliferative disorders. Using 18F-FDG PET/CT, we aimed to evaluate its benefit in early detection of various accompanying disorders and illnesses in MGUS patients. We prospectively analyzed the diagnostic relevance of 18F-FDG PET/CT in 390 newly diagnosed MGUS patients. On 18F-FDG PET/CT scans, the presence of focal or diffuse areas of detectable increased tracer uptake was recorded in 37 (9.5%) MGUS patients. The most frequent pathology was lymphadenopathy (3.8%), followed by thyroid diseases (2.1%), rheumatic diseases (1.8%), and other solid malignancies (1.5%). These results have major implications for confirmed associations of MGUS with numerous malignant and non-malignant disorders. We believe that 18F-FDG PET/CT imaging in newly diagnosed MGUS patients may be useful in early detection of other serious pathologies, not only in predicting progression of MGUS to active MM, and should be strongly recommended if available.
ER -
SANDECKÁ, Viera, Zdeněk ADAM, Marta KREJČÍ, Martin ŠTORK, Zdeněk ŘEHÁK, Renata KOUKALOVÁ, Sabina ŠEVČÍKOVÁ, Lucie BROŽOVÁ, Zdeněk KRÁL, Jiří MAYER and Luděk POUR. Diagnostic relevance of 18F-FDG PET/CT in newly diagnosed patients with monoclonal gammopathy of undetermined significance (MGUS): Single-center experience. \textit{Neoplasma}. Bratislava: Slovenská akademie vied, 2020, vol.~67, No~4, p.~939-945. ISSN~0028-2685. Available from: https://dx.doi.org/10.4149/neo\_{}2020\_{}191104N1137.
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