| PEKAŘÍK, Vladimír, Marie KUDLIČKOVÁ PEŠKOVÁ, Jakub DUBEN, Marek REMES a Zbynek HEGER. Direct fluorogenic detection of palladium and platinum organometallic complexes with proteins and nucleic acids in polyacrylamide gels. Scientific reports. LONDON: NATURE PUBLISHING GROUP, 2020, roč. 10, č. 1, s. 1-10. ISSN 2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-020-69336-w. |
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@article{1676538,
author = {Pekařík, Vladimír and Kudličková Pešková, Marie and Duben, Jakub and Remes, Marek and Heger, Zbynek},
article_location = {LONDON},
article_number = {1},
doi = {http://dx.doi.org/10.1038/s41598-020-69336-w},
keywords = {Direct fluorogenic detection; palladium and platinum organometallic complexes; polyacrylamide gels},
language = {eng},
issn = {2045-2322},
journal = {Scientific reports},
title = {Direct fluorogenic detection of palladium and platinum organometallic complexes with proteins and nucleic acids in polyacrylamide gels},
url = {https://www.nature.com/articles/s41598-020-69336-w.pdf},
volume = {10},
year = {2020}
}
TY - JOUR
ID - 1676538
AU - Pekařík, Vladimír - Kudličková Pešková, Marie - Duben, Jakub - Remes, Marek - Heger, Zbynek
PY - 2020
TI - Direct fluorogenic detection of palladium and platinum organometallic complexes with proteins and nucleic acids in polyacrylamide gels
JF - Scientific reports
VL - 10
IS - 1
SP - 1-10
EP - 1-10
PB - NATURE PUBLISHING GROUP
SN - 20452322
KW - Direct fluorogenic detection
KW - palladium and platinum organometallic complexes
KW - polyacrylamide gels
UR - https://www.nature.com/articles/s41598-020-69336-w.pdf
L2 - https://www.nature.com/articles/s41598-020-69336-w.pdf
N2 - Allyl- and propargyl ethers of umbelliferone are sensitive probes for palladium and platinum, including anticancer compounds cisplatin, carboplatin and oxaliplatin, and effective for direct visualization of protein and DNA complexes with organometallic compounds in polyacrylamide gels allowing easy detection of interactions with analyzed protein or nucleic acid. Both probes can be used for fast evaluation of Pd/Pt binding to nanocarriers relevant in drug targeted therapy or specific clinically relevant target macromolecules.
ER -
PEKAŘÍK, Vladimír, Marie KUDLIČKOVÁ PEŠKOVÁ, Jakub DUBEN, Marek REMES a Zbynek HEGER. Direct fluorogenic detection of palladium and platinum organometallic complexes with proteins and nucleic acids in polyacrylamide gels. \textit{Scientific reports}. LONDON: NATURE PUBLISHING GROUP, 2020, roč.~10, č.~1, s.~1-10. ISSN~2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-020-69336-w.
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