JOUKAL, Marek, Lucy VULCHANOVA, Cecilia HUFFMAN, Petr DUBOVÝ a Christopher N. HONDA. Peripheral Deltorphin II Inhibits Nociceptors Following Nerve Injury. Frontiers in Pharmacology. Lausanne: Frontiers Media SA, 2020, roč. 11, JUL 2020, s. 1-10. ISSN 1663-9812. Dostupné z: https://dx.doi.org/10.3389/fphar.2020.01151. |
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@article{1677641, author = {Joukal, Marek and Vulchanova, Lucy and Huffman, Cecilia and Dubový, Petr and Honda, Christopher N.}, article_location = {Lausanne}, article_number = {JUL 2020}, doi = {http://dx.doi.org/10.3389/fphar.2020.01151}, keywords = {nociceptors; spared nerve injury; delta opioid receptors; neuropathic pain; deltorphin II}, language = {eng}, issn = {1663-9812}, journal = {Frontiers in Pharmacology}, title = {Peripheral Deltorphin II Inhibits Nociceptors Following Nerve Injury}, url = {https://www.frontiersin.org/articles/10.3389/fphar.2020.01151/full}, volume = {11}, year = {2020} }
TY - JOUR ID - 1677641 AU - Joukal, Marek - Vulchanova, Lucy - Huffman, Cecilia - Dubový, Petr - Honda, Christopher N. PY - 2020 TI - Peripheral Deltorphin II Inhibits Nociceptors Following Nerve Injury JF - Frontiers in Pharmacology VL - 11 IS - JUL 2020 SP - 1-10 EP - 1-10 PB - Frontiers Media SA SN - 16639812 KW - nociceptors KW - spared nerve injury KW - delta opioid receptors KW - neuropathic pain KW - deltorphin II UR - https://www.frontiersin.org/articles/10.3389/fphar.2020.01151/full L2 - https://www.frontiersin.org/articles/10.3389/fphar.2020.01151/full N2 - Clinical and preclinical studies have revealed that local administration of opioid agonists into peripheral tissue attenuates inflammatory pain. However, few studies have examined whether peripherally restricted opioids are effective in reducing mechanical allodynia and hyperalgesia that usually follows nerve injury. The aim of the present study was to determine whether the mechanical responsiveness of C-fiber mechanical nociceptors innervating skin under neuropathic pain conditions is depressed by direct activation of delta opioid receptors (DORs) on their peripheral terminals. A murine model of peripheral neuropathic pain was induced with a spared nerve (tibial) injury, in which mice survived 7 or 28 days after surgery before electrophysiological testing began. Control groups comprised naive and sham-operated animals. An ex vivo preparation of mouse plantar skin with attached tibial nerve was used to examine electrophysiologically the effects of the selective DOR agonist, deltorphin II, on the response properties of individual cutaneous C-fiber nociceptors. In contrast to naive and sham-operated animals, deltorphin II induced an inhibition of the mechanical responsiveness of C-fiber mechanical nociceptors innervating skin under neuropathic conditions. The effects of deltorphin II were concentration-dependent and prevented by pretreatment with naltrindole indicating DOR-mediated inhibitory effects of deltorphin II. Our results provide the first direct evidence for expression of functional DORs on mechanical nociceptors innervating skin in an animal model of neuropathic pain. ER -
JOUKAL, Marek, Lucy VULCHANOVA, Cecilia HUFFMAN, Petr DUBOVÝ a Christopher N. HONDA. Peripheral Deltorphin II Inhibits Nociceptors Following Nerve Injury. \textit{Frontiers in Pharmacology}. Lausanne: Frontiers Media SA, 2020, roč.~11, JUL 2020, s.~1-10. ISSN~1663-9812. Dostupné z: https://dx.doi.org/10.3389/fphar.2020.01151.
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