Enhanced Intracellular Accumulation and Cytotoxicity of
Ferrocene-Ruthenium Arene Conjugates.

J 2020

Enhanced Intracellular Accumulation and Cytotoxicity of Ferrocene-Ruthenium Arene Conjugates.

GELLE, Donát, Martin LAMAČ, Karel MACH, Ludmila ŠIMKOVÁ, Róbert GYEPES et. al.

Základní údaje

Originální název

Enhanced Intracellular Accumulation and Cytotoxicity of Ferrocene-Ruthenium Arene Conjugates.

Autoři

GELLE, Donát, Martin LAMAČ, Karel MACH, Ludmila ŠIMKOVÁ, Róbert GYEPES, Lucia SOMMEROVÁ, Andrea MARTIŠOVÁ (703 Slovensko), Martin BARTOŠÍK, Tomáš VACULOVIČ (203 Česká republika, domácí), Viktor KANICKÝ (203 Česká republika, domácí), Roman HRSTKA (garant) a Jiří PINKAS

Vydání

ChemPlusChem, Weinheim, Wiley - Verlag Chemie, 2020, 2192-6506

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10406 Analytical chemistry

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.863

Kód RIV

RIV/00216224:14310/20:00116353

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1002/cplu.202000022

UT WoS

000536506200031

Klíčová slova anglicky

antitumor agents; electrochemistry; ferrocene; metallocene; ruthenium

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 5. 11. 2020 19:12, Mgr. Marie Šípková, DiS.

Anotace

V originále

Coordination of arenophilic Cp*Ru+ (Cp*=eta(5)-C5Me5) fragment to pendant aromatic ring(s) of either benzylferrocene (1) or dibenzylferrocene (2) gave air- and water-stable dinuclear (4) or trinuclear (6) ferrocene-ruthenium conjugates. The complexes were characterized by NMR, ESI-MS, cyclic voltammetry (CV), elemental analysis, and the molecular structure of 4 was established by single crystal X-ray diffraction. Contrary to the starting ferrocenes 1 and 2, conjugates 4 and 6 showed significant in vitro anticancer activity (up to IC50 0.6 +/- 0.2 mu M) against various cancer cell lines (A2780, SK-OV-3, MDA-MB-231). Differential pulse voltammetry (DPV) showed that the intracellular accumulation of 4 was approximately twice that of 6 in all studied cell lines, which corresponds to a higher cytotoxicity of 4.

Citovat

GELLE, Donát, Martin LAMAČ, Karel MACH, Ludmila ŠIMKOVÁ, Róbert GYEPES, Lucia SOMMEROVÁ, Andrea MARTIŠOVÁ, Martin BARTOŠÍK, Tomáš VACULOVIČ, Viktor KANICKÝ, Roman HRSTKA a Jiří PINKAS. Enhanced Intracellular Accumulation and Cytotoxicity of Ferrocene-Ruthenium Arene Conjugates. ChemPlusChem. Weinheim: Wiley - Verlag Chemie, 2020, roč. 85, č. 5, s. 1034-1043. ISSN 2192-6506. Dostupné z: https://dx.doi.org/10.1002/cplu.202000022.

@article{1677701,
   author = {Gelle, Donát and Lamač, Martin and Mach, Karel and Šimková, Ludmila and Gyepes, Róbert and Sommerová, Lucia and Martišová, Andrea and Bartošík, Martin and Vaculovič, Tomáš and Kanický, Viktor and Hrstka, Roman and Pinkas, Jiří},
   article_location = {Weinheim},
   article_number = {5},
   doi = {http://dx.doi.org/10.1002/cplu.202000022},
   keywords = {antitumor agents; electrochemistry; ferrocene; metallocene; ruthenium},
   language = {eng},
   issn = {2192-6506},
   journal = {ChemPlusChem},
   title = {Enhanced Intracellular Accumulation and Cytotoxicity of Ferrocene-Ruthenium Arene Conjugates.},
   url = {https://doi.org/10.1002/cplu.202000022},
   volume = {85},
   year = {2020}
}

TY  - JOUR
ID  - 1677701
AU  - Gelle, Donát - Lamač, Martin - Mach, Karel - Šimková, Ludmila - Gyepes, Róbert - Sommerová, Lucia - Martišová, Andrea - Bartošík, Martin - Vaculovič, Tomáš - Kanický, Viktor - Hrstka, Roman - Pinkas, Jiří
PY  - 2020
TI  - Enhanced Intracellular Accumulation and Cytotoxicity of Ferrocene-Ruthenium Arene Conjugates.
JF  - ChemPlusChem
VL  - 85
IS  - 5
SP  - 1034-1043
EP  - 1034-1043
PB  - Wiley - Verlag Chemie
SN  - 21926506
KW  - antitumor agents
KW  - electrochemistry
KW  - ferrocene
KW  - metallocene
KW  - ruthenium
UR  - https://doi.org/10.1002/cplu.202000022
L2  - https://doi.org/10.1002/cplu.202000022
N2  - Coordination of arenophilic Cp*Ru+ (Cp*=eta(5)-C5Me5) fragment to pendant aromatic ring(s) of either benzylferrocene (1) or dibenzylferrocene (2) gave air- and water-stable dinuclear (4) or trinuclear (6) ferrocene-ruthenium conjugates. The complexes were characterized by NMR, ESI-MS, cyclic voltammetry (CV), elemental analysis, and the molecular structure of 4 was established by single crystal X-ray diffraction. Contrary to the starting ferrocenes 1 and 2, conjugates 4 and 6 showed significant in vitro anticancer activity (up to IC50 0.6 +/- 0.2 mu M) against various cancer cell lines (A2780, SK-OV-3, MDA-MB-231). Differential pulse voltammetry (DPV) showed that the intracellular accumulation of 4 was approximately twice that of 6 in all studied cell lines, which corresponds to a higher cytotoxicity of 4.
ER  -

GELLE, Donát, Martin LAMAČ, Karel MACH, Ludmila ŠIMKOVÁ, Róbert GYEPES, Lucia SOMMEROVÁ, Andrea MARTIŠOVÁ, Martin BARTOŠÍK, Tomáš VACULOVIČ, Viktor KANICKÝ, Roman HRSTKA a Jiří PINKAS. Enhanced Intracellular Accumulation and Cytotoxicity of Ferrocene-Ruthenium Arene Conjugates. \textit{ChemPlusChem}. Weinheim: Wiley - Verlag Chemie, 2020, roč.~85, č.~5, s.~1034-1043. ISSN~2192-6506. Dostupné z: https://dx.doi.org/10.1002/cplu.202000022.

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