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@article{1677701,
author = {Gelle, Donát and Lamač, Martin and Mach, Karel and Šimková, Ludmila and Gyepes, Róbert and Sommerová, Lucia and Martišová, Andrea and Bartošík, Martin and Vaculovič, Tomáš and Kanický, Viktor and Hrstka, Roman and Pinkas, Jiří},
article_location = {Weinheim},
article_number = {5},
doi = {http://dx.doi.org/10.1002/cplu.202000022},
keywords = {antitumor agents; electrochemistry; ferrocene; metallocene; ruthenium},
language = {eng},
issn = {2192-6506},
journal = {ChemPlusChem},
title = {Enhanced Intracellular Accumulation and Cytotoxicity of Ferrocene-Ruthenium Arene Conjugates.},
url = {https://doi.org/10.1002/cplu.202000022},
volume = {85},
year = {2020}
}
TY - JOUR
ID - 1677701
AU - Gelle, Donát - Lamač, Martin - Mach, Karel - Šimková, Ludmila - Gyepes, Róbert - Sommerová, Lucia - Martišová, Andrea - Bartošík, Martin - Vaculovič, Tomáš - Kanický, Viktor - Hrstka, Roman - Pinkas, Jiří
PY - 2020
TI - Enhanced Intracellular Accumulation and Cytotoxicity of Ferrocene-Ruthenium Arene Conjugates.
JF - ChemPlusChem
VL - 85
IS - 5
SP - 1034-1043
EP - 1034-1043
PB - Wiley - Verlag Chemie
SN - 21926506
KW - antitumor agents
KW - electrochemistry
KW - ferrocene
KW - metallocene
KW - ruthenium
UR - https://doi.org/10.1002/cplu.202000022
L2 - https://doi.org/10.1002/cplu.202000022
N2 - Coordination of arenophilic Cp*Ru+ (Cp*=eta(5)-C5Me5) fragment to pendant aromatic ring(s) of either benzylferrocene (1) or dibenzylferrocene (2) gave air- and water-stable dinuclear (4) or trinuclear (6) ferrocene-ruthenium conjugates. The complexes were characterized by NMR, ESI-MS, cyclic voltammetry (CV), elemental analysis, and the molecular structure of 4 was established by single crystal X-ray diffraction. Contrary to the starting ferrocenes 1 and 2, conjugates 4 and 6 showed significant in vitro anticancer activity (up to IC50 0.6 +/- 0.2 mu M) against various cancer cell lines (A2780, SK-OV-3, MDA-MB-231). Differential pulse voltammetry (DPV) showed that the intracellular accumulation of 4 was approximately twice that of 6 in all studied cell lines, which corresponds to a higher cytotoxicity of 4.
ER -
GELLE, Donát, Martin LAMAČ, Karel MACH, Ludmila ŠIMKOVÁ, Róbert GYEPES, Lucia SOMMEROVÁ, Andrea MARTIŠOVÁ, Martin BARTOŠÍK, Tomáš VACULOVIČ, Viktor KANICKÝ, Roman HRSTKA a Jiří PINKAS. Enhanced Intracellular Accumulation and Cytotoxicity of Ferrocene-Ruthenium Arene Conjugates. \textit{ChemPlusChem}. Weinheim: Wiley - Verlag Chemie, 2020, roč.~85, č.~5, s.~1034-1043. ISSN~2192-6506. Dostupné z: https://dx.doi.org/10.1002/cplu.202000022.
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