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@article{1677757,
author = {Toman, Ondřej and Hnátková, Kateřina and Smetana, Peter and Huster, Katharina M. and Šišáková, Martina and Barthel, Petra and Novotný, Tomáš and Schmidt, Georg and Malík, Marek},
article_location = {London},
article_number = {1},
doi = {http://dx.doi.org/10.1038/s41598-020-59480-8},
keywords = {physiologic heart rate dependency; PQ interval; sex differences},
language = {eng},
issn = {2045-2322},
journal = {Scientific Reports},
title = {Physiologic heart rate dependency of the PQ interval and its sex differences},
url = {https://www.nature.com/articles/s41598-020-59480-8},
volume = {10},
year = {2020}
}
TY - JOUR
ID - 1677757
AU - Toman, Ondřej - Hnátková, Kateřina - Smetana, Peter - Huster, Katharina M. - Šišáková, Martina - Barthel, Petra - Novotný, Tomáš - Schmidt, Georg - Malík, Marek
PY - 2020
TI - Physiologic heart rate dependency of the PQ interval and its sex differences
JF - Scientific Reports
VL - 10
IS - 1
SP - 1-17
EP - 1-17
PB - Nature Publishing Group
SN - 20452322
KW - physiologic heart rate dependency
KW - PQ interval
KW - sex differences
UR - https://www.nature.com/articles/s41598-020-59480-8
L2 - https://www.nature.com/articles/s41598-020-59480-8
N2 - On standard electrocardiogram (ECG) PQ interval is known to be moderately heart rate dependent, but no physiologic details of this dependency have been established. At the same time, PQ dynamics is a clear candidate for non-invasive assessment of atrial abnormalities including the risk of atrial fibrillation. We studied PQ heart rate dependency in 599 healthy subjects (aged 33.5 +/- 9.3 years, 288 females) in whom drug-free day-time 12-lead ECG Holters were available. Of these, 752,517 ECG samples were selected (1256 +/- 244 per subject) to measure PQ and QT intervals and P wave durations. For each measured ECG sample, 5-minute history of preceding cardiac cycles was also obtained. Although less rate dependent than the QT intervals (36 +/- 19% of linear slopes), PQ intervals were found to be dependent on underlying cycle length in a highly curvilinear fashion with the dependency significantly more curved in females compared to males. The PQ interval also responded to the heart rate changes with a delay which was highly sex dependent (95% adaptation in females and males after 114.9 +/- 81.1 vs 65.4 +/- 64.3 seconds, respectively, p < 0.00001). P wave duration was even less rate dependent than the PQ interval (9 +/- 10% of linear QT/RR slopes). Rate corrected P wave duration was marginally but significantly shorter in females than in males (106.8 +/- 8.4 vs 110.2 +/- 7.9 ms, p < 0.00001). In addition to establishing physiologic standards, the study suggests that the curvatures and adaptation delay of the PQ/cycle-length dependency should be included in future non-invasive studies of atrial depolarizations.
ER -
TOMAN, Ondřej, Kateřina HNÁTKOVÁ, Peter SMETANA, Katharina M. HUSTER, Martina ŠIŠÁKOVÁ, Petra BARTHEL, Tomáš NOVOTNÝ, Georg SCHMIDT a Marek MALÍK. Physiologic heart rate dependency of the PQ interval and its sex differences. \textit{Scientific Reports}. London: Nature Publishing Group, 2020, roč.~10, č.~1, s.~1-17. ISSN~2045-2322. Dostupné z: https://dx.doi.org/10.1038/s41598-020-59480-8.
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