HPV, protein p16 and squamous cell carcinoma of the oral cavity

J 2020

HPV, protein p16 and squamous cell carcinoma of the oral cavity

BLAHÁK, Jiří, Jiří ZELINKA, Jaromír GUMULEC, Ctirad MACHÁČEK, Zdeněk DANĚK et. al.

Základní údaje

Originální název

HPV, protein p16 and squamous cell carcinoma of the oral cavity

Autoři

BLAHÁK, Jiří (203 Česká republika, garant, domácí), Jiří ZELINKA (203 Česká republika, domácí), Jaromír GUMULEC (203 Česká republika, domácí), Ctirad MACHÁČEK (203 Česká republika, domácí), Zdeněk DANĚK (203 Česká republika, domácí) a Oliver BULIK (203 Česká republika, domácí)

Vydání

Biomedical Papers, Olomouc, Univerzita Palackého v Olomouci, 2020, 1213-8118

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30109 Pathology

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 1.245

Kód RIV

RIV/00216224:14110/20:00116360

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.5507/bp.2019.026

UT WoS

000595645600011

Klíčová slova anglicky

oral squamous cell carcinoma; oral cancer; HPV; human papilloma virus; p16

Štítky

14110227, 14110230, 14110518, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 5. 1. 2021 12:04, Mgr. Tereza Miškechová

Anotace

V originále

Background: Squamous cell carcinoma of the oral cavity is generally caused by the long-term impact of known risk factors, e.g. tobacco and alcohol, along with chronic traumatisation. A number of studies now implicate HPV infection in head and neck tumour carcinogenesis but the exact role of HPV infection in the oral cavity remains unclear. Methods: In this study, we evaluated 78 patients with oral squamous cell carcinoma (OSCC) for the expression of protein p16 in the context of HPV positivity and its influence on the overall survival rate, disease location, staging and grading. Results: Regarding the tumour location, no significant difference was found between HPV-positive and HPV-negative patients, nor between p16-positive and p16-negative patients. There was also no trend in terms of HPV status and stage, and differentiation of carcinoma. There was no effect on HPV-positive patients relative to the time to progression (P=0.84) and overall survival rate (P=0.78). P16 positivity was not found to have an effect on the overall survival rate of patients (P=0.41) and there was no correlation between p16 positivity relative to the time to progression (P=0.66). Conclusions: In summary, the data suggest that there is no effect of HPV status on the prognosis of OSCC patients compared to other HNSCC locations.

Citovat

BLAHÁK, Jiří, Jiří ZELINKA, Jaromír GUMULEC, Ctirad MACHÁČEK, Zdeněk DANĚK a Oliver BULIK. HPV, protein p16 and squamous cell carcinoma of the oral cavity. Biomedical Papers. Olomouc: Univerzita Palackého v Olomouci, 2020, roč. 164, č. 3, s. 292-299. ISSN 1213-8118. Dostupné z: https://dx.doi.org/10.5507/bp.2019.026.

@article{1677823,
   author = {Blahák, Jiří and Zelinka, Jiří and Gumulec, Jaromír and Macháček, Ctirad and Daněk, Zdeněk and Bulik, Oliver},
   article_location = {Olomouc},
   article_number = {3},
   doi = {http://dx.doi.org/10.5507/bp.2019.026},
   keywords = {oral squamous cell carcinoma; oral cancer; HPV; human papilloma virus; p16},
   language = {eng},
   issn = {1213-8118},
   journal = {Biomedical Papers},
   title = {HPV, protein p16 and squamous cell carcinoma of the oral cavity},
   url = {https://biomed.papers.upol.cz/corproof.php?tartkey=bio-000000-2105},
   volume = {164},
   year = {2020}
}

TY  - JOUR
ID  - 1677823
AU  - Blahák, Jiří - Zelinka, Jiří - Gumulec, Jaromír - Macháček, Ctirad - Daněk, Zdeněk - Bulik, Oliver
PY  - 2020
TI  - HPV, protein p16 and squamous cell carcinoma of the oral cavity
JF  - Biomedical Papers
VL  - 164
IS  - 3
SP  - 292-299
EP  - 292-299
PB  - Univerzita Palackého v Olomouci
SN  - 12138118
KW  - oral squamous cell carcinoma
KW  - oral cancer
KW  - HPV
KW  - human papilloma virus
KW  - p16
UR  - https://biomed.papers.upol.cz/corproof.php?tartkey=bio-000000-2105
L2  - https://biomed.papers.upol.cz/corproof.php?tartkey=bio-000000-2105
N2  - Background: Squamous cell carcinoma of the oral cavity is generally caused by the long-term impact of known risk factors, e.g. tobacco and alcohol, along with chronic traumatisation. A number of studies now implicate HPV infection in head and neck tumour carcinogenesis but the exact role of HPV infection in the oral cavity remains unclear. Methods: In this study, we evaluated 78 patients with oral squamous cell carcinoma (OSCC) for the expression of protein p16 in the context of HPV positivity and its influence on the overall survival rate, disease location, staging and grading. Results: Regarding the tumour location, no significant difference was found between HPV-positive and HPV-negative patients, nor between p16-positive and p16-negative patients. There was also no trend in terms of HPV status and stage, and differentiation of carcinoma. There was no effect on HPV-positive patients relative to the time to progression (P=0.84) and overall survival rate (P=0.78). P16 positivity was not found to have an effect on the overall survival rate of patients (P=0.41) and there was no correlation between p16 positivity relative to the time to progression (P=0.66). Conclusions: In summary, the data suggest that there is no effect of HPV status on the prognosis of OSCC patients compared to other HNSCC locations.
ER  -

BLAHÁK, Jiří, Jiří ZELINKA, Jaromír GUMULEC, Ctirad MACHÁČEK, Zdeněk DANĚK a Oliver BULIK. HPV, protein p16 and squamous cell carcinoma of the oral cavity. \textit{Biomedical Papers}. Olomouc: Univerzita Palackého v Olomouci, 2020, roč.~164, č.~3, s.~292-299. ISSN~1213-8118. Dostupné z: https://dx.doi.org/10.5507/bp.2019.026.

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