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@article{1677823,
author = {Blahák, Jiří and Zelinka, Jiří and Gumulec, Jaromír and Macháček, Ctirad and Daněk, Zdeněk and Bulik, Oliver},
article_location = {Olomouc},
article_number = {3},
doi = {http://dx.doi.org/10.5507/bp.2019.026},
keywords = {oral squamous cell carcinoma; oral cancer; HPV; human papilloma virus; p16},
language = {eng},
issn = {1213-8118},
journal = {Biomedical Papers},
title = {HPV, protein p16 and squamous cell carcinoma of the oral cavity},
url = {https://biomed.papers.upol.cz/corproof.php?tartkey=bio-000000-2105},
volume = {164},
year = {2020}
}
TY - JOUR
ID - 1677823
AU - Blahák, Jiří - Zelinka, Jiří - Gumulec, Jaromír - Macháček, Ctirad - Daněk, Zdeněk - Bulik, Oliver
PY - 2020
TI - HPV, protein p16 and squamous cell carcinoma of the oral cavity
JF - Biomedical Papers
VL - 164
IS - 3
SP - 292-299
EP - 292-299
PB - Univerzita Palackého v Olomouci
SN - 12138118
KW - oral squamous cell carcinoma
KW - oral cancer
KW - HPV
KW - human papilloma virus
KW - p16
UR - https://biomed.papers.upol.cz/corproof.php?tartkey=bio-000000-2105
L2 - https://biomed.papers.upol.cz/corproof.php?tartkey=bio-000000-2105
N2 - Background: Squamous cell carcinoma of the oral cavity is generally caused by the long-term impact of known risk factors, e.g. tobacco and alcohol, along with chronic traumatisation. A number of studies now implicate HPV infection in head and neck tumour carcinogenesis but the exact role of HPV infection in the oral cavity remains unclear. Methods: In this study, we evaluated 78 patients with oral squamous cell carcinoma (OSCC) for the expression of protein p16 in the context of HPV positivity and its influence on the overall survival rate, disease location, staging and grading. Results: Regarding the tumour location, no significant difference was found between HPV-positive and HPV-negative patients, nor between p16-positive and p16-negative patients. There was also no trend in terms of HPV status and stage, and differentiation of carcinoma. There was no effect on HPV-positive patients relative to the time to progression (P=0.84) and overall survival rate (P=0.78). P16 positivity was not found to have an effect on the overall survival rate of patients (P=0.41) and there was no correlation between p16 positivity relative to the time to progression (P=0.66). Conclusions: In summary, the data suggest that there is no effect of HPV status on the prognosis of OSCC patients compared to other HNSCC locations.
ER -
BLAHÁK, Jiří, Jiří ZELINKA, Jaromír GUMULEC, Ctirad MACHÁČEK, Zdeněk DANĚK a Oliver BULIK. HPV, protein p16 and squamous cell carcinoma of the oral cavity. \textit{Biomedical Papers}. Olomouc: Univerzita Palackého v Olomouci, 2020, roč.~164, č.~3, s.~292-299. ISSN~1213-8118. Dostupné z: https://dx.doi.org/10.5507/bp.2019.026.
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